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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

IL-8和MCP-1对Tau磷酸化和磷酸酶活性的影响

卷 17, 期 11, 2020

页: [985 - 1000] 页: 16

弟呕挨: 10.2174/1567205017666201130091129

价格: $65

摘要

背景：慢性炎症是阿尔茨海默氏病（AD）的特征，导致炎症介质过多产生，可导致神经炎症，导致Aβ产生改变和老年斑（SP）沉积，并导致神经原纤维缠结（NFT） 形成，是由于Tau蛋白过度磷酸化。 目的：这项工作解决了两种趋化因子白介素8（IL-8）和单核细胞趋化蛋白-1（MCP-1）对Tau磷酸化的影响；并使用区域队列的样本评估了血浆中趋化因子的水平。 方法：通过蛋白质印迹分析监测暴露于IL-8和MCP-1趋化因子的人神经元SH-SY5Y细胞的蛋白和磷酸化蛋白水平。丝氨酸/苏氨酸蛋白磷酸酶（PPs）活性测定用于监测PPs活性。随后，使用流式细胞仪监测患有认知缺陷的个体血浆样品中的趋化因子水平。 结果：趋化因子的暴露仅对SH-SY5Y产生较小的细胞毒性作用，并增加Tau磷酸化，特别是在S396残基上。 Tau磷酸化与PPs抑制作用相关，并且与GSK3β磷酸化介导的抑制作用一致。随后对具有认知缺陷的个体的血浆进行的分析表明，IL-8水平降低了。 结论：数据表明，所测试的两种趋化因子均可对GSK3β磷酸化产生影响并调节PPs活性，从而可能导致Tau磷酸化增加并随后形成NFT。可以推断出在慢性炎症过程中增加的趋化因子刺激会加剧这一事件。这项工作有助于更好地了解这些趋化因子对AD发病机理的作用方式，并开辟了新的研究途径。

关键词: 趋化因子，IL-8，MCP-1，阿尔茨海默氏病，tau，激酶，磷酸酶。

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