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Review Article

IFN家族在异常炎症性骨溶解中的重要作用

卷 21, 期 2, 2021

发表于: 27 November, 2020

页: [112 - 129] 页: 18

弟呕挨: 10.2174/1566523220666201127114845

价格: $65

摘要

骨骼系统被认为是高度动态的系统，其中成骨的成骨细胞和吸收骨的破骨细胞经历连续的重塑周期，以维持骨基质的稳态。众所周知，干扰素（IFNs）作为细胞因子的一个亚组，不仅对调节免疫学起着至关重要的作用，而且还可以调节骨基质的动态平衡。根据不同的同工型，就氨基酸序列，特异性受体的识别和生物活性而言，IFN已分为三大类。目前，I型干扰素由具有多个亚型的多基因家族组成，其中干扰素-α发挥促成骨细胞作用，以激活成骨细胞分化并抑制破骨细胞融合，从而维持骨基质的完整性。同时，IFN-β抑制成骨细胞介导的骨重塑，并表现出对破骨细胞分化的抑制作用，从而减弱骨吸收。 II型IFN是唯一的IFN-γ类型，它通过双相方式对破骨细胞的骨吸收和成骨细胞的形成发挥调节作用。有趣的是，III型干扰素被认为是由四个成员组成的IFN家族的新成员，包括IFN-λ1（IL-29），IFN-λ2（IL-28A），IFN-λ3（IL-28B）和IFN-λ4，已经被证明可以参与骨质破坏。然而，关于III型干扰素如何调节骨基质代谢平衡的直接调控机制仍未阐明。在这篇综述中，我们总结了干扰素家族在生理和病理条件下的功能，并描述了干扰素通过影响破骨细胞-成骨细胞串扰来维持骨基质稳态的机制。此外，还充分展示了IFN对类风湿性关节炎（RA），骨关节炎（OA）和传染性骨病等炎症性骨破坏疾病的潜在治疗作用，这是基于IFN在调节TNF的动态平衡中的主要作用。骨基质。

关键词: 干扰素(IFNs)、成骨细胞-成骨细胞串扰、骨稳态、炎症性骨破坏疾病、骨骼、骨形成的成骨细胞。

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图形摘要

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