Contribution of Rs780094 and Rs1260326 Polymorphisms in GCKR Gene to Non-alcoholic Fatty Liver Disease: A Meta-Analysis Involving 26,552 Participants

Title:Contribution of Rs780094 and Rs1260326 Polymorphisms in GCKR Gene to Non-alcoholic Fatty Liver Disease: A Meta-Analysis Involving 26,552 Participants

Volume: 21 Issue: 9

Author(s): Jiaying Li, Yuening Zhao, Hongxiang Zhang, Wenxi Hua, Wenzhi Jiao, Xuan Du, Jingwen Rui, Si Li, Haiying Teng, Bimin Shi*, Xiaoqin Yang*Liyan Zhu*

Affiliation:

• Department of Endocrinology and Metabolism, the First Affiliated Hospital of Soochow University, Suzhou 215006,China

• Center for Systems Biology, Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123,China

• Experimental Center of Medical College, Soochow University, 199 Ren'ai Road, Suzhou 215123, Jiangsu,China

Keywords: Non-alcoholic fatty liver disease, glucokinase regulator gene, rs780094, rs1260326, meta-analysis, susceptibility.

Abstract:

Background: Many published studies attempted to elucidate the implication of glucokinase regulator gene (GCKR) polymorphisms in the susceptibility to non-alcoholic fatty liver disease (NAFLD), but the results among them were still controversial.

Objective: This meta-analysis aims to precisely assess the relationship between the GCKR polymorphisms and the risk of NAFLD.

Methods: Systematic computerized searches in six databases were performed and updated on April 6, 2020. Meta-analyses were conducted by calling the R programs based on accumulated epidemiological data. Odds ratio (OR) and 95% confidential interval (CI) were calculated to summarize the effect estimates.

Results: In total, 25 studies including 6,598 cases and 19,954 controls were included. The pooled estimates indicated that the T allele carrier of the GCKR rs780094 polymorphism has predisposition to NAFLD (allele model: OR: 1.20, 95% CI: 1.11~1.29; homozygote model: OR: 1.38, 95% CI: 1.15~1.67; heterozygote model: OR: 1.25, 95% CI: 1.12~1.39; dominant model: OR: 1.29, 95% CI: 1.13~1.47; recessive model: OR: 1.18, 95% CI: 1.06~1.31), and the same as the rs1260326 polymorphism (allele model: OR: 1.32, 95% CI: 1.22~1.42; homozygote model: OR: 1.65, 95% CI: 1.40~1.94; heterozygote model: OR: 1.24, 95% CI: 1.07~1.43; dominant model: OR: 1.39, 95% CI: 1.21~1.59; recessive model: OR: 1.44, 95% CI: 1.28~1.62). Further stratified analyses according to age and ethnicity confirmed the statistical existence in most subgroups.

Conclusion: This meta-analysis suggested that both of the GCKR rs780094 and rs1260326 polymorphisms are significantly associated with the increased risk of NAFLD.

Cite this article as:

Li Jiaying , Zhao Yuening , Zhang Hongxiang , Hua Wenxi , Jiao Wenzhi , Du Xuan , Rui Jingwen , Li Si , Teng Haiying , Shi Bimin *, Yang Xiaoqin *, Zhu Liyan *, Contribution of Rs780094 and Rs1260326 Polymorphisms in GCKR Gene to Non-alcoholic Fatty Liver Disease: A Meta-Analysis Involving 26,552 Participants, Endocrine, Metabolic & Immune Disorders - Drug Targets 2021; 21 (9) . https://dx.doi.org/10.2174/1871530320999201126202706