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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Isatin: A Scaffold with Immense Biodiversity

Author(s): Priyobrata Nath, Agnish Mukherjee, Sougata Mukherjee, Sabyasachi Banerjee, Samarpita Das and Subhasis Banerjee*

Volume 21, Issue 9, 2021

Published on: 25 November, 2020

Page: [1096 - 1112] Pages: 17

DOI: 10.2174/2211536609666201125115559

Price: $65

Abstract

Isatin is an endogenous and a significant category of fused heterocyclic components and has widely been a part of several potential biologically useful synthetics. Since its discovery, tons of research work has been conducted with respect to the synthesis, chemical properties, and biological and industrial applications. It contains an indole nucleus having both lactam and keto moiety, which, while being a part of a molecular framework, exerted several biological effects, viz.; anti-microbial, anti-tubercular, anticonvulsant, anti-cancer, etc. Isatin derivatives are synthetically significant substrates, which can be utilized for the synthesis of huge diversified chemical entities of which few members emerged as drugs. The reason for this review is to provide extensive information pertaining to the chemistry and its significance in altering several pathological states of isatin and its derivatives. A Structure-Activity Relationship study thus developed through a gamut of scientific information indicates the importance of mostly electron-withdrawing groups, halogens, nitro, alkoxy, and, to a minor extent, groups with positive inductive effects, such as methyl at position 1, 5, 6 and 7 of isatin in alleviating several clinical conditions. It is also observed from the survey that the presence of two oxo groups at positions 2 and 3 sometimes becomes insignificant as a fusion with a heterocycle at these positions resulted in a biologically relevant compound.

Keywords: Isatin, anti-microbial, anticonvulsant, anti-cancer, anti-tubercular, anti-inflammatory.

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Graphical Abstract

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