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Current Applied Polymer Science

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ISSN (Print): 2452-2716
ISSN (Online): 2452-2724

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Mini-Review Article

Polysarcosine: The Best Alternative of Poly (Ethylene Glycol)

Author(s): Manu Singhai and Sankha Bhattacharya*

Volume 4, Issue 2, 2021

Published on: 24 November, 2020

Page: [93 - 98] Pages: 6

DOI: 10.2174/2452271604999201124222313

Price: $65

Abstract

Polysarcosine (psar) is a non-ionic hydrophilic polypeptoid with numerous biologically relevant properties. Polysarcosine is poly (n-methylated glycine) and has been reported first by Weslay and co-workers in the 1920s. Polysarcosine was first synthesized via ring-opening polymerization (rop) of sarcosine n-carboxyanhydride, using high-vacuum techniques. Overall, findings highlight the potential of poly(sarcosine) as an alternative corona-forming polymer to poly (ethylene glycol)-based analogues of (polymerization-induced self-assembly) pisa assemblies for use in various pharmaceutical and biomedical applications. Numerous studies suggested that such polypeptoids hold enormous potential for many biomedical applications, including protein delivery, colloidal stabilization, and nanomedicine.

Keywords: Polysarcosine, polypeptoid, PEGylation, nanomedicine, biomedical applications poly (Ethylene Glycol), N-methylated glycine.

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