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Current Medical Imaging

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ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

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Research Article

Impaired Reconversion of Bone Marrow in Nuclear Magnetic Resonance in Patients with Chronic Renal Disease

Author(s): Franklin Mora-Bravo* and Javier Muñoz

Volume 17, Issue 10, 2021

Published on: 18 November, 2020

Page: [1256 - 1261] Pages: 6

DOI: 10.2174/1573405616999201118140832

Price: $65

Abstract

Background: Anemia is one of the main consequences of Chronic Kidney Disease (CKD), which causes a bone marrow response determined by Magnetic Resonance Imaging.

Objective: The objective of this study was to identify Bone Marrow Reconversion (BMR) by nuclear magnetic resonance imaging in patients with CKD.

Methods: A descriptive study was carried in “José Carrasco Arteaga” Hospital, Cuenca-Ecuador. Images of the femurs of patients diagnosed with CKD were acquired by magnetic resonance imaging. Several variables, including age, sex, CKD stage, anemia and BMR, were taken into account. Groups are analyzed according to the stages CKD with the Anova test and logistic regression is obtained for the BMR event with the study variables.

Results: Two hundred sixteen patients were included in this analysis. Prevalences of Anemia were 2/40 (5%) in Group 1, 3/35 (8.6%) in group 2, 17/56 (30.4%) in group 3, 23/46 (50%) in group 4 and 25/39 (64.1%) in group 5, Anova P<0.0001. BMR in Group 1 was 12 cases (30%), in group 2: 4 cases (11.4%), in group 3: 18 cases (32.1%), in group 4: 13 cases (28.3%), and group 5: 17 cases (43.6%). P=0.51. Regression equation for BMR were significant with sex (male) OR 0.193 (CI95% 0.092-0.405) P<0.0001, CKD Stage 1 OR 0.195 (0.057-0.668) P=0.009, Stage 2 OR 0.082 (0.020-0.329). Other variables were not significant.

Conclusion: In this study, we describe that there is an impaired Reconversion of Bone Marrow in Nuclear Magnetic Resonance Imaging in Patients with Chronic Renal Disease in stages 3, 4 and 5, despite the progressive presence of anemia. The female sex is associated with the presence of bone marrow reconversion. No statistical dependence was observed between anemia and the reconversion of bone marrow.

Keywords: Anemia, magnetic resonance imaging, bone marrow reconversion, chronic kidney disease, uraemia, femur.

Graphical Abstract

[1]
Cases-Amenós A, Martínez-Castelao A, Fort-Ros J, et al. Investigadores del Estudio Micenas I. Prevalence of anaemia and its clinical management in patients with stages 3-5 chronic kidney disease not on dialysis in Catalonia: MICENAS I study. Nefrologia 2014; 34(2): 189-98.
[http://dx.doi.org/10.3265/Nefrologia.pre2013.Dec.12261] [PMID: 24658193]
[2]
Martínez-Castelao A, Górriz JL, Segura-de la Morena J, et al. Consensus document for the detection and management of chronic kidney disease. Nefrologia 2014; 34(2): 243-62.
[http://dx.doi.org/10.1016/j.semerg.2014.09.001] [PMID: 24658201]
[3]
Lombardo M, Andrade L, Demicheli H, et al. Anemia associated renal functional impairment without dialysis requirements current situation in Argentina - APREDIA study. Nefrología. Diálisis y Trasplante 2014; 34: 112-22.
[4]
Adera H, Hailu W, Adane A, Tadesse A. Prevalence of anemia and its associated factors among chronic kidney disease patients at university of gondar hospi-tal, northwest ethiopia: A hospital-based cross sectional study. Int J Nephrol Renovasc Dis 2019; 12: 219-28.
[http://dx.doi.org/10.2147/IJNRD.S216010] [PMID: 31686891]
[5]
Vilanova JC, Luna A. Bone marrow invasion in multiple myeloma and metastatic disease. Radiologia (Madr) 2016; 58(Suppl. 1): 81-93.
[http://dx.doi.org/10.1016/j.rx.2015.11.002] [PMID: 26767542]
[6]
Núñez E, García A, Tovar M, et al. Evaluación de la médula ósea por resonancia magnética: utilidad de la técnica de difusión. Seram 2014; S-1153: 1-34.
[http://dx.doi.org/10.1594/seram2014/S-1153]
[7]
Sanz Sanz J. Role of MRI in the diagnosis and progression of spondyloarthritis. Reumatol Clin 2012; 8(Suppl. 1): S37-41.
[http://dx.doi.org/10.1016/j.reuma.2011.12.002] [PMID: 22342265]
[8]
Kishida Y, Koyama H, Seki S, et al. Comparison of fat suppression capability for chest MR imaging with Dixon, SPAIR and STIR techniques at 3 Tesla MR system. Magn Reson Imaging 2018; 47: 89-96.
[http://dx.doi.org/10.1016/j.mri.2017.11.012] [PMID: 29180099]
[9]
Sales C, Álvarez V, Escudero M, et al. Alteraciones multifocales de la señal de la médula ósea de los cuerpos vertebrales en RM. Diagnóstico diferencial. Radiologia (Madr) 2014; 56: 1043.
[10]
Durand J, Karoubi M, Anract P, et al. Metástasis óseas: manejo multidisciplinario, conducta diagnóstica y terapéutica EMC - Aparato Locomotor 2013; 46: 1-16.
[http://dx.doi.org/10.1016/S1286-935X(13)64172-6]
[11]
Małkiewicz A, Dziedzic M. Bone marrow reconversion - imaging of physiological changes in bone marrow. Pol J Radiol 2012; 77(4): 45-50.
[PMID: 23269936]
[12]
Hansen S. The use of whole body magnetic resonance imaging in detecting bone marrow disorders – a valid alternative to imaging modalities that utilise ionising radiation. Radiographer 2005; 52: 17-20.http://www.minniscomms.com.au/articles/Radiographer%20dec%2005%20Hansen.pdf
[http://dx.doi.org/10.1002/j.2051-3909.2005.tb00036.x]
[13]
Zhao F, Shen J, Yu X, Zhou H, Lu Z, Yan S. Bone marrow reconversion mimicking pelvis metastases in a patient with rectal cancer: a pitfall on magnetic resonance images. Quant Imaging Med Surg 2018; 8(6): 621-6.
[http://dx.doi.org/10.21037/qims.2018.07.03] [PMID: 30140624]
[14]
Caranci F, Tedeschi E, Ugga L, et al. Magnetic Resonance Imaging correlates of benign and malignant alterations of the spinal bone marrow. Acta Biomed 2018; 89(1-S): 18-33.
[http://dx.doi.org/10.23750/abm.v89i1-S.7008] [PMID: 29350635]

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