摘要
背景:许多临床研究已经揭示了偏头痛与重度抑郁症 (MD) 之间的关联。这两种疾病都影响了大量的全球人口。更多地了解这两种疾病的共病机制可以为开发新的治疗方法提供线索。 方法:据我们所知,文献中还没有任何基于 microRNA (miRNA) 生物标志物来研究 MD 与偏头痛之间的关系的研究。在这项研究中,我们根据它们的 miRNA 生物标志物讨论了这两种疾病之间的关联。除了 miRNA 生物标志物,我们还根据台湾生物库 (TWB) 数据证明了它们之间的关联的流行病学证据。 结果:在 12 个偏头痛 miRNA 生物标志物中,11 个与 MD 相关。只有 miR-181a 没有直接证据参与 MD 的机制。除了生物标志物证据外,使用 TWB 收集的大规模流行病学数据的统计分析为 MD 与偏头痛之间的关系提供了强有力的证据。 结论:基于分子和流行病学数据的证据揭示了 MD 与偏头痛之间的显着关联。这一结果有助于研究这两种疾病的相关潜在机制。
关键词: 生物标志物、重度抑郁症、偏头痛、microRNA、流行病学研究、合并症。
Current Medicinal Chemistry
Title:The Association between Migraine and Depression based on miRNA Biomarkers and Cohort Studies
Volume: 28 Issue: 27
关键词: 生物标志物、重度抑郁症、偏头痛、microRNA、流行病学研究、合并症。
摘要:
Background: An association between migraine and Major Depression (MD) has been revealed in a number of clinical studies. Both diseases have affected a large global population. More understanding of the comorbidity mechanism of these two diseases can shed light on developing new therapies for their treatment.
Methods: To the best of our knowledge, there have not been any researches in the literature based on microRNA (miRNA) biomarkers to investigate the relationship between MD and migraine. In this study, we have discussed the association between these two diseases based on their miRNA biomarkers. In addition to miRNA biomarkers, we have also demonstrated epidemiological evidence for their association based on Taiwan Biobank (TWB) data.
Results: Among the 12 migraine miRNA biomarkers, 11 are related to MD. Only miR-181a has no direct evidence to be involved in the mechanism of MD. In addition to the biological biomarker evidence, the statistical analysis using the large-scale epidemiologic data collected from TWB provides strong evidence on the relationship between MD and migraine.
Conclusion: The evidence based on both molecular and epidemiological data reveals the significant association between MD and migraine. This result can help investigate the correlated underlying mechanism of these two diseases.
Export Options
About this article
Cite this article as:
The Association between Migraine and Depression based on miRNA Biomarkers and Cohort Studies, Current Medicinal Chemistry 2021; 28 (27) . https://dx.doi.org/10.2174/0929867327666201117100026
DOI https://dx.doi.org/10.2174/0929867327666201117100026 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Anti-Hormonal Therapies for Premenopausal Patients – What did we Learn from the TEXT/SOFT Trials?
Reviews on Recent Clinical Trials Preface: Scope of Current Alzheimer Research Debomoy
Current Alzheimer Research Cognitive Mechanisms in Decision-Making in Patients With Mild Alzheimer Disease
Current Alzheimer Research Vitamin D and N-Acetyl Cysteine Supplementation in Treatment-Resistant Depressive Disorder Patients: A General Review
Current Pharmaceutical Design Pharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury
Current Neuropharmacology A Simplified Protocol for Routine Chemoselective Syntheses of Piperazines Substituted in the 1-Position by an Electron Withdrawing Group
Current Organic Synthesis A Quantitative Proteomic Analysis to Reveal Effects of N-acetylcysteine on H<sub>2</sub>O<sub>2</sub>-induced Cytotoxicity
Current Proteomics Herb-Drug Interactions in Neurological Disorders: A Critical Appraisal
Current Drug Metabolism Correlation Between Structure, Retention and Lipophilicity of Some Antidepressants: QSRR and QSAR Studies
Letters in Drug Design & Discovery Understanding Effects of Psychological Stress on Physiology and Disease Through Human Stressome - An Integral Algorithm
Current Bioinformatics Resisting the Sun with Vitamin D
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Intracranial Cerebrospinal Fluid Volume Evaluation in Healthy People and Hydrocephalus Patients using SPACE Sequence
Current Medical Imaging Overview and Developments Regarding Functional Foods and Beverages
Current Nutrition & Food Science Cellular and Network Mechanisms Underlying Memory Impairment Induced by Amyloid β Protein
Protein & Peptide Letters Ziconotide: Neuronal Calcium Channel Blocker for Treating Severe Chronic Pain
Current Medicinal Chemistry Mesenchymal Stem Cells Promote Caspase Expression in Molt-4 Leukemia Cells <i>Via</i> GSK-3α/Β and ERK1/2 Signaling Pathways as a Therapeutic Strategy
Current Gene Therapy Pathologically-Activated Therapeutics for Neuroprotection: Mechanism of NMDA Receptor Block by Memantine and S-Nitrosylation
Current Drug Targets Editorial [Hot Topic: Innate Immunity and Autoimmune Disease (Guest Editors: F. Susan Wong and Li Wen)]
Current Molecular Medicine Glutamine, Glucose and other Fuels for Cancer
Current Pharmaceutical Design Physiology of Immune System: Regulation of Stem Cell Survival
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued)