摘要
背景:许多临床研究已经揭示了偏头痛与重度抑郁症 (MD) 之间的关联。这两种疾病都影响了大量的全球人口。更多地了解这两种疾病的共病机制可以为开发新的治疗方法提供线索。 方法:据我们所知,文献中还没有任何基于 microRNA (miRNA) 生物标志物来研究 MD 与偏头痛之间的关系的研究。在这项研究中,我们根据它们的 miRNA 生物标志物讨论了这两种疾病之间的关联。除了 miRNA 生物标志物,我们还根据台湾生物库 (TWB) 数据证明了它们之间的关联的流行病学证据。 结果:在 12 个偏头痛 miRNA 生物标志物中,11 个与 MD 相关。只有 miR-181a 没有直接证据参与 MD 的机制。除了生物标志物证据外,使用 TWB 收集的大规模流行病学数据的统计分析为 MD 与偏头痛之间的关系提供了强有力的证据。 结论:基于分子和流行病学数据的证据揭示了 MD 与偏头痛之间的显着关联。这一结果有助于研究这两种疾病的相关潜在机制。
关键词: 生物标志物、重度抑郁症、偏头痛、microRNA、流行病学研究、合并症。
Current Medicinal Chemistry
Title:The Association between Migraine and Depression based on miRNA Biomarkers and Cohort Studies
Volume: 28 Issue: 27
关键词: 生物标志物、重度抑郁症、偏头痛、microRNA、流行病学研究、合并症。
摘要:
Background: An association between migraine and Major Depression (MD) has been revealed in a number of clinical studies. Both diseases have affected a large global population. More understanding of the comorbidity mechanism of these two diseases can shed light on developing new therapies for their treatment.
Methods: To the best of our knowledge, there have not been any researches in the literature based on microRNA (miRNA) biomarkers to investigate the relationship between MD and migraine. In this study, we have discussed the association between these two diseases based on their miRNA biomarkers. In addition to miRNA biomarkers, we have also demonstrated epidemiological evidence for their association based on Taiwan Biobank (TWB) data.
Results: Among the 12 migraine miRNA biomarkers, 11 are related to MD. Only miR-181a has no direct evidence to be involved in the mechanism of MD. In addition to the biological biomarker evidence, the statistical analysis using the large-scale epidemiologic data collected from TWB provides strong evidence on the relationship between MD and migraine.
Conclusion: The evidence based on both molecular and epidemiological data reveals the significant association between MD and migraine. This result can help investigate the correlated underlying mechanism of these two diseases.
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Cite this article as:
The Association between Migraine and Depression based on miRNA Biomarkers and Cohort Studies, Current Medicinal Chemistry 2021; 28 (27) . https://dx.doi.org/10.2174/0929867327666201117100026
DOI https://dx.doi.org/10.2174/0929867327666201117100026 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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