基于紫杉醇的自我输送纳米药物用于癌症治疗的最新进展

Title:Recent Advances in Paclitaxel-based Self-Delivery Nanomedicine for Cancer Therapy

Volume: 28 Issue: 31

关键词: 紫杉醇、自我递送、纳米医学、自组装、无载体、癌症治疗、SDN。

摘要: Paclitaxel (PTX) is the first natural plant-derived chemotherapeutic drug approved by the Food and Drug Administration. However, the clinical applications of PTX are limited by some drawbacks, such as poor water solubility, rapid blood clearance, nonspecific distribution, and adverse side effects. Nanocarriers have made important contributions to drug delivery and cancer therapy in recent years. However, low drug loading capacity, nanocarrier excipients-induced toxicity or immunogenicity, and complicated synthesis technologies pose a challenge for the clinical application of nanocarriers. To address these issues, the self-delivery nanomedicine (SDNs), in which pure drug molecules directly self-assemble into nanomedicine, have been developed for drug delivery and enhancing antitumor efficacy. In this review, we comprehensively summarize the recent advances in PTX-based SDNs for cancer therapy. First, the self-assembly strategies to develop pure PTX nanodrugs are discussed. Then, the emerging strategies of co-assembly PTX and other therapeutic agents for effective combination therapy are presented, composing of combination chemotherapy, chemo-photothermal therapy, chemo-photodynamic therapy, chemo-immunotherapy, and chemo-gene therapy. Finally, the limitations and future outlook of SDNs are discussed. The rational design of these unique nanoplatforms may make a new direction to develop highly efficient drug delivery systems for cancer therapy.

Cite this article as:

Recent Advances in Paclitaxel-based Self-Delivery Nanomedicine for Cancer Therapy, Current Medicinal Chemistry 2021; 28 (31) . https://dx.doi.org/10.2174/0929867327666201111143725