黄酮类化合物的 mTOR 靶向癌症化学预防

Title:mTOR Targeted Cancer Chemoprevention by Flavonoids

Volume: 28 Issue: 39

关键词: 芹菜素、黄芩素、癌症预防、黄豆苷元、表没食子儿茶素-3-没食子酸酯、类黄酮、染料木黄酮、木犀草素、橘子素、mTOR。

摘要: Over the past several decades, plant-derived products (phytochemicals) have been suggested to possess immense therapeutic potential. Among these phytochemicals, different flavonoids have been reported for their potent anticancer activity. To exhibit their anticancer potential, these flavonoids modulate different signaling pathways. Among these pathways, the mammalian target of rapamycin (mTOR) and associated phosphatidyl-inositol 3-kinase (PI3K)/protein kinase B (Akt) signaling cascade have been reported as a pivotal modulator of cell survival, proliferation, and death/apoptosis. Hence, targeting this cascade could be an ideal strategy to alleviate apoptosis and inhibit proliferation in different forms of cancer. The targeting of PI3K/Akt/mTOR by flavonoids have been well documented in the scientific literature. In the current study, we have studied the anticancer potential of various flavonoids, especially flavones, flavonols, and isoflavones that include apigenin, luteolin, baicalein, tangeretin, epigallocatechin- 3-gallate, genistein, and daidzein especially dealing with mTOR targeting.

Cite this article as:

mTOR Targeted Cancer Chemoprevention by Flavonoids, Current Medicinal Chemistry 2021; 28 (39) . https://dx.doi.org/10.2174/0929867327666201109122025