Expanding the Arsenal Against Huntington's Disease-Herbal Drugs and Their Nanoformulations

Title:Expanding the Arsenal Against Huntington's Disease-Herbal Drugs and Their Nanoformulations

Volume: 19 Issue: 7

Author(s): Sukriti Vishwas, Monica Gulati, Bhupinder Kapoor, Saurabh Gupta*, Sachin Kumar Singh*, Ankit Awasthi, Arzoo Khan, Aditya Goyal, Anil Bansal, Suman Baishnab, Thakur Gurjeet Singh, Sandeep Arora, Omji Porwal, Ankit Kumar and Vijay Kumar

Affiliation:

• Chitkara College of Pharmacy, Chitkara University, Punjab-140401,India

• School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab-144411,India

Keywords: Huntington's disorder, oxidative stress, herbal medicine, neuroprotective effects, blood-brain barrier, nanocarriers.

Abstract: Huntington’s disease (HD) is an autosomal fatal genetic disease in which degeneration of neuronal cells occurs in the central nervous system (CNS). Commonly used therapeutics are cludemonoamine depletors, antipsychotics, antidepressants, and tranquilizers. However, these drugs cannot prevent the psychotic, cognitive, and behavioral dysfunctions associated with HD. In addition to this, their chronic use is limited by their long-term side effects. Herbal drugs offer a plausible alternative to this and have shown substantial therapeutic effects against HD. Moreover, their safety profile is better in terms of side effects. However, due to limited drug solubility and permeability to reach the target site, herbal drugs have not been able to reach the stage of clinical exploration. In recent years, the paradigm of research has been shifted towards the development of herbal drugs based nanoformulations that can enhance their bioavailability and blood-brain barrier permeability. The present review covers the pathophysiology of HD, available biomarkers, phytomedicines explored against HD, ongoing clinical trials on herbal drugs exclusively for treating HD and their nanocarriers, along with their potential neuroprotective effects.

Cite this article as:

Vishwas Sukriti , Gulati Monica , Kapoor Bhupinder , Gupta Saurabh*, Singh Kumar Sachin *, Awasthi Ankit, Khan Arzoo, Goyal Aditya , Bansal Anil , Baishnab Suman , Singh Gurjeet Thakur , Arora Sandeep , Porwal Omji , Kumar Ankit and Kumar Vijay , Expanding the Arsenal Against Huntington's Disease-Herbal Drugs and Their Nanoformulations, Current Neuropharmacology 2021; 19 (7) . https://dx.doi.org/10.2174/1570159X18666201109090824