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Review Article

醛糖还原酶抑制剂治疗炎症性疾病和癌症的研究进展：当前药物设计策略和未来方向

卷 28, 期 19, 2021

发表于: 27 October, 2020

页: [3683 - 3712] 页: 30

弟呕挨: 10.2174/0929867327666201027152737

价格: $65

摘要

醛糖还原酶(AR)是一种在葡萄糖代谢的多元醇途径中将葡萄糖转化为山梨醇的酶。由于AR参与引起渗透和氧化应激，因此它已被证明与继发性糖尿病并发症的发生有关。在临床研究中，已经测试了各种AR抑制剂用于治疗继发性糖尿病并发症，如视网膜病、神经病和肾病。最近的研究还表明，增强现实在调解各种炎症并发症中的潜在作用。因此，除了糖尿病之外，对用于治疗炎性并发症和癌症的AR抑制剂的开发和潜在用途的研究目前正在增加。此外，基因突变研究、计算机建模和分子动力学研究有助于设计新的和有效的AR抑制剂。本文讨论了除了糖尿病并发症外，AR抑制剂在治疗炎症和癌症方面的潜在新用途。此外，我们还总结了过去几十年中为治疗目的而设计和开发的AR抑制剂的研究进展。

关键词: 醛糖还原酶，醛糖还原酶抑制剂，糖尿病，新药研发，炎症，癌症。

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