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Mini-Review Article

天然衍生和合成药物对鲍曼不动杆菌毒性因子的抑制和生物膜的形成

卷 22, 期 7, 2021

发表于: 23 October, 2020

页: [734 - 759] 页: 26

弟呕挨: 10.2174/1389450121666201023122355

价格: $65

摘要

鲍氏不动杆菌是革兰氏阴性，需氧，不运动和多形性杆菌。鲍曼弧菌也是一种高传染性病原体，在重症监护病房造成高死亡率和发病率。由于耐药鲍氏不动杆菌菌株的出现和可用于治疗的有效抗生素数量有限，迫切需要发现抗鲍氏不动杆菌感染的新药物。鲍氏不动杆菌除了能产生几种致病因子外，还能在宿主细胞表面形成生物膜。生物膜的形成经历了最初的表面附着、微菌落形成、生物膜成熟和分离阶段，是鲍氏不动杆菌的主要耐药机制之一。此前有几项研究报道了天然衍生和合成化合物作为抗生物膜和抗鲍曼弧菌毒力剂的功效。本文综述了鲍氏不动杆菌生物膜形成的抑制作用及其致病因子的研究进展。

关键词: 鲍氏不动杆菌，抗生物膜，抗病毒，化合物，多重耐药，合成。

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