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Review Article

大黄素-甲醚和大黄素-甲醚8-O-β-D-葡萄糖醛苷：具有潜在抗癌活性的天然蒽醌

卷 22, 期 5, 2021

发表于: 13 October, 2020

页: [488 - 504] 页: 17

弟呕挨: 10.2174/1389450121999201013154542

价格: $65

摘要

自古以来，自然界就为药物开发提供了大量的药理活性化合物。 大黄素-甲醚和大黄素-甲醚-O-β-D-吡喃葡萄糖苷（PG）是具有生物活性的天然蒽醌，具有抗炎和抗癌特性，且副作用很小或没有副作用。此外，大黄素-甲醚还具有抗微生物和保肝作用，而PG则具有防腐作用以及对痴呆症的改善作用。这篇综述的目的是强调大黄素-甲醚和PG的天然来源和抗癌活性，以及相关的作用机理。在文献的基础上，大黄素-甲醚和PG通过调节细胞周期，蛋白激酶，microRNA，转录因子和凋亡相关蛋白的各种调节剂来调节多种细胞信号传导途径，从而有效地杀死了癌细胞以及在体外。体内。两种化合物均有效抑制转移，此外，大黄素-甲醚可以作为6PGD的抑制剂，并在化学增敏中起重要作用。这篇综述文章认为，大黄素-甲醚和PG是有效的抗癌药物候选者，但是必须进一步研究它们的作用机理和临床前试验，以便了解这些天然癌症杀手在抗癌疗法中的全部潜力。

关键词: 大黄素-甲醚，大黄素-甲醚-O-β-D-吡喃葡萄糖苷，天然产物，蒽醌，抗癌剂，化学致敏作用。

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