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Mini-Review Article

COVID-19与肾脏疾病:最新进展

卷 22, 期 1, 2021

发表于: 13 October, 2020

页: [52 - 67] 页: 16

弟呕挨: 10.2174/1389450121999201013151300

价格: $65

摘要

背景：越来越明显的是，SARS-CoV-2感染不仅仅局限于呼吸系统。肾脏除了是病毒的目标外，似乎对该病的结局也有重大影响。 方法：检索PubMed、Cochrane、Scopus和SciELO数据库，主要检索词为“SARS-CoV-2”、“COVID-19”、“慢性肾脏疾病”、“肾移植”、“急性肾损伤”和“肾功能不全”。 讨论：膜结合的血管紧张素转换酶2是SARS-CoV- 2的受体，这种相互作用可能导致肾素-血管紧张素系统(RAS)失衡，与COVID-19的更糟糕的临床表现相关，包括急性肺损伤、高炎症状态和血液学改变。在肾脏疾病的框架内，急性肾损伤的发展主要与病毒引起的免疫改变和直接细胞病变有关，导致较高的死亡率。对于慢性肾脏疾病，非终末期患者预后较差，而血液透析患者COVID-19病程较轻，可能是由于受细胞因子风暴影响的机会较低。此外，目前的情况不利于肾脏捐献和移植。COVID-19与肾移植受者免疫抑制之间的关系已被广泛讨论，以确定它是否会增加死亡率以及它如何与免疫抑制药物相互作用。 结论：肾脏和RAS在SARS-CoV-2感染中发挥基础性作用，需要更多的研究来全面了解COVID-19在肾脏疾病中造成的影响。

关键词: SARS-CoV-2

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