Facile Synthesis of (E)-5-Styrylpyrimidines via Wittig Reaction Using Sodium Tripolyphosphate in Water

Title:Facile Synthesis of (E)-5-Styrylpyrimidines via Wittig Reaction Using Sodium Tripolyphosphate in Water

Volume: 18 Issue: 8

Author(s): Anilkumar S. Patel*, Sahaj A. Gandhi, Rajesh D. Modh, Urmila H. Patel, Yogesh T. Naliapara and Naval P. Kapuriya*

Affiliation:

• Department of Chemistry, Atmiya University, Rajkot-360005, Gujarat,India

• Department of Chemistry and Forensic Science, Bhakta Kavi Narsinh Mehta University, Bilkha Road, Khadia, Junagadh-362263, Gujarat,India

Keywords: Wittig reaction, (E)-5-styrylpyrimidines, green chemistry, water-mediated, sodium tripolyphosphate.

Abstract: An inexpensive and eco-friendly Wittig olefination protocol has been developed to prepare novel (E)-5-styrylpyrimidines. The reaction of pyrimidine phosphonium ylide with different aryl/heteroaryl aldehydes underwent smoothly in the presence of sodium tripolyphosphate (STPP) in aqueous condition giving (E)-5-styrylpyrimidines (10a-t) in very high yields (77-96 %).

Cite this article as:

Patel S. Anilkumar *, Gandhi A. Sahaj , Modh D. Rajesh , Patel H. Urmila , Naliapara T. Yogesh and Kapuriya P. Naval *, Facile Synthesis of (E)-5-Styrylpyrimidines via Wittig Reaction Using Sodium Tripolyphosphate in Water, Letters in Organic Chemistry 2021; 18 (8) . https://dx.doi.org/10.2174/1570178617999201012181526