Login Register Cart 0
Generic placeholder image

Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Review Article

Promising Anti-cancer Therapeutics From Mushrooms: Current Findings and Future Perceptions

Author(s): Mrunmaya K. Panda, Manish Paul, Sameer K. Singdevsachan, Kumananda Tayung, Swagat K. Das and Hrudayanath Thatoi*

Volume 22, Issue 9, 2021

Published on: 08 October, 2020

Page: [1164 - 1191] Pages: 28

DOI: 10.2174/1389201021666201008164056

Price: $65

Abstract

Background: Nowadays, medicines derived from natural sources have drawn much attention as potential therapeutic agents in the suppression and treatment of cancer because of their low toxicity and fewer side effects.

Objective: The present review aims to assess the currently available knowledge on the ethnomedicinal uses and pharmacological activities of bioactive compounds obtained from medicinal mushrooms towards cancer treatment.

Methods: A literature search has been conducted for the collection of research papers from universally accepted scientific databases. These research papers and published book chapters were scrutinized to retrieve information on ethnomedicinal uses of mushrooms, different factors involved in cancer cell proliferation, clinical and in silico pharmaceutical studies made for possible treatments of cancer using mushroom derived compounds. Overall, 241 articles were retrieved and reviewed from the year 1970 to 2020, out of which 98 relevant articles were finally considered for the preparation of this review.

Results: This review presents an update on the natural bioactive substances derived from medicinal mushrooms and their role in inhibiting the factors responsible for cancer cell proliferation. Along with it, the present review also provides information on the ethnomedicinal uses, solvents used for extraction of anti-cancer metabolites, clinical trials, and in silico studies that were undertaken towards anticancer drug development from medicinal mushrooms.

Conclusion: The present review provides extensive knowledge on various anti-cancer substances obtained from medicinal mushrooms, their biological actions, and in silico drug designing approaches, which could form a basis for the development of natural anti-cancer therapeutics.

Keywords: Medicinal mushrooms, mushroom extracts, cancer therapeutics, ethnomedicinal uses, clinical trials, in silico study.

« Previous Next »
Graphical Abstract

[1]
Wasser, S.P. Medicinal mushrooms in human clinical studies. Part 1. Anticancer, oncoimmunological, and immunomodulatory activities: A review. Int. J. Med. Mushrooms, 2017, 19(4), 279-317.
[http://dx.doi.org/10.1615/IntJMedMushrooms.v19.i4.10] [PMID: 28605319]
[2]
Dai, Y.C.; Yang, Z.L.; Cui, B.K.; Yu, C.J.; Zhou, L.W. Species diversity and utilization of medicinal mushrooms and fungi in China. Int. J. Med. Mushrooms, 2009, 11(3), 287-302.
[http://dx.doi.org/10.1615/IntJMedMushr.v11.i3.80]
[3]
Elsayed, E.A.; El Enshasy, H.; Wadaan, M.A.; Aziz, R. Mushrooms: a potential natural source of anti-inflammatory compounds for medical applications. Mediators Inflamm., 2014, 2014, 805841.
[4]
Patel, S.; Goyal, A. Recent developments in mushrooms as anticancer therapeutics: A review. 3 Biotech., 2012, 2(1), 15.
[5]
Zhang, Y.; Lapidus, R.G.; Liu, P.; Choi, E.Y.; Adediran, S.; Hussain, A.; Wang, X.; Liu, X.; Dan, H.C. Targeting IκB kinase β/NF-κB signaling in human prostate cancer by a novel IκB kinase β inhibitor CmpdA. Mol. Cancer Ther., 2016, 15(7), 1504-1514.
[http://dx.doi.org/10.1158/1535-7163.MCT-15-0999] [PMID: 27196761]
[6]
Zhang, J.J.; Li, Y.; Zhou, T.; Xu, D.P.; Zhang, P.; Li, S.; Li, H.B. Bioactivities and health benefits of mushrooms mainly from China. Molecules, 2016, 21(7), 938.
[http://dx.doi.org/10.3390/molecules21070938] [PMID: 27447602]
[7]
Khatua, S.; Paul, S.; Acharya, K. Mushroom as the potential source of new generation of antioxidant: A review. RJPT, 2018, 6(5), 496-505.
[8]
Chaturvedi, V.K.; Agarwal, S.; Gupta, K.K.; Ramteke, P.W.; Singh, M. Medicinal mushroom: Boon for therapeutic applications. 3Bioteh, 2018, 8(8), 334.
[9]
Chen, W.; Zhao, Z.; Li, L.; Wu, B.; Chen, S.F.; Zhou, H.; Wang, Y.; Li, Y.Q. Hispolon induces apoptosis in human gastric cancer cells through a ROS-mediated mitochondrial pathway. Free Radic. Biol. Med., 2008, 45(1), 60-72.
[http://dx.doi.org/10.1016/j.freeradbiomed.2008.03.013] [PMID: 18423410]
[10]
Kasahara, Y.; Itou, T. Determination of illudin S in Omphalotus guepiniformis and foods that caused food poisoning by liquid chromatography with tandem mass spectrometry. Shokuhin Eiseigaku Zasshi, 2009, 50(4), 167-172.
[http://dx.doi.org/10.3358/shokueishi.50.167] [PMID: 19745584]
[11]
Qiang, L.; Wu, T.; Zhang, H.W.; Lu, N.; Hu, R.; Wang, Y.J.; Zhao, L.; Chen, F.H.; Wang, X.T.; You, Q.D.; Guo, Q.L. HIF-1α is critical for hypoxia-mediated maintenance of glioblastoma stem cells by activating Notch signaling pathway. Cell Death Differ., 2012, 19(2), 284-294.
[http://dx.doi.org/10.1038/cdd.2011.95] [PMID: 21818118]
[12]
World Health Organization. https://www.who.int/health-topics/cancer#tab=tab_1
[13]
Schulz, A. Cancer Prevention.Molecular Biology of Human Cancers: An advances student’s textbook; Springer Science & Business Media, 2007.
[14]
Standish, L.J.; Wenner, C.A.; Sweet, E.S.; Bridge, C.; Nelson, A.; Martzen, M.; Novack, J.; Torkelson, C. Trametes versicolor mushroom immune therapy in breast cancer. J. Soc. Integr. Oncol., 2008, 6(3), 122-128.
[PMID: 19087769]
[15]
Lemieszek, M.K.; Langner, E.; Kaczor, J.; Kandefer-Szerszen, M.; Sanecka, B.; Mazurkiewicz, W.; Rzeski, W. Anticancer effect of fraction isolated from medicinal Birch polypore mushroom, Piptoporus betulinus (Bull.: Fr.) P. Karst. (Aphyllophoromycetideae): In vitro studies. Int. J. Med. Mushrooms, 2009, 11, 351-364.
[http://dx.doi.org/10.1615/IntJMedMushr.v11.i4.20]
[16]
Yang, H.L.; Kuo, Y.H.; Tsai, C.T.; Huang, Y.T.; Chen, S.C.; Chang, H.W.; Lin, E.; Lin, W.H.; Hseu, Y.C. Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway. Food Chem. Toxicol., 2011, 49(1), 290-298.
[http://dx.doi.org/10.1016/j.fct.2010.10.031] [PMID: 21056076]
[17]
Valverde, M.E.; Hernández-Pérez, T.; Paredes-López, O. Edible mushrooms: Improving human health and promoting quality life. Int. J. Microbiol., 2015, 2015, 376387.
[18]
Feitelson, M.A.; Arzumanyan, A.; Kulathinal, R.J.; Blain, S.W.; Holcombe, R.F. Mahajna, J.; Marino, M.; Martinez-Chantar, M.L.; Nawroth, R.; Sanchez-Garcia, I.; Sharma, D.; Saxena, N.K.; Singh, N.; Vlachostergios, P.J.; Guo, S.; Honoki, K.; Fujii, H.; Georgakilas, A.G.; Bilsland, A.; Amedei, A.; Niccolai, E.; Amin, A.; Ashraf, S.S.; Boosani, C.S.; Guha, G.; Ciriolo, M.R.; Aquilano, K.; Chen, S.; Mohammed, S.I.; Azmi, A.S.; Bhakta, D.; Halicka, D.; Keith, W.N.; Nowsheen, S. Sustained proliferation in cancer: Mechanisms and novel therapeutic targets. Semin. Cancer Biol., 2015, 35, S25-S54.
[19]
Kapetanovic, I.M. Computer-aided drug discovery and development (CADDD): In silico-chemico-biological approach. Chem. Biol. Interact., 2008, 171(2), 165-176.
[http://dx.doi.org/10.1016/j.cbi.2006.12.006] [PMID: 17229415]
[20]
Shrestha, R.; Shrestha, B. Green Energy Mission/Nepal. Proceedings of National Conference on Wild relatives of Cultivated plants in Kathmandu, Nepal1999, pp. 2-4.
[21]
Lau, B.F.; Abdullah, N.; Aminudin, N.; Lee, H.B.; Tan, P.J. Ethnomedicinal uses, pharmacological activities, and cultivation of Lignosus spp. (tiger׳s milk mushrooms) in Malaysia - A review. J. Ethnopharmacol., 2015, 169, 441-458.
[http://dx.doi.org/10.1016/j.jep.2015.04.042] [PMID: 25937256]
[22]
Noorlidah, A.; Vikineswary, S.; Yusoff, M. Insights into the edible and medicinal mushrooms of Kenaboi Forest Reserve, Jelebu, Negeri Sembilan, Malaysia. MJMS, 2009, 28(4), 389-395.
[23]
Abdullah, N.; Wahab, A.I.A.; Beng, F.L.; Zainal, A.N.; Aminudin, N. Proceedings of the Fifth International Peptide Symposium, 2011, Vol 2010, p. 78.
[24]
Lai, C.K.; Wong, K.H.; Cheung, P.C.K. Antiproliferative effects of sclerotial polysaccharides from Polyporus rhinocerus Cooke (Aphyllophoromycetideae) on different kinds of leukemic cells. Int. J. Med. Mushrooms, 2008, 10(3), 255-264.
[http://dx.doi.org/10.1615/IntJMedMushr.v10.i3.60]
[25]
Lau, B.F.; Abdullah, N.; Aminudin, N.; Lee, H.B. Chemical composition and cellular toxicity of ethnobotanical-based hot and cold aqueous preparations of the tiger’s milk mushroom (Lignosus rhinocerotis). J. Ethnopharmacol., 2013, 150(1), 252-262.
[http://dx.doi.org/10.1016/j.jep.2013.08.034] [PMID: 23993912]
[26]
Lau, B.F.; Abdullah, N.; Aminudin, N.; Lee, H.B.; Yap, K.C.; Sabaratnam, V. The potential of mycelium and culture broth of Lignosus rhinocerotis as substitutes for the naturally occurring sclerotium with regard to antioxidant capacity, cytotoxic effect, and low-molecular-weight chemical constituents. PLoS One, 2014, 9(7), e102509.
[http://dx.doi.org/10.1371/journal.pone.0102509] [PMID: 25054862]
[27]
Lee, K.H.; Morris-Natschke, S.L.; Yang, X.; Huang, R.; Zhou, T.; Wu, S.F.; Shi, Q.; Itokawa, H. Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine. J. Tradit. Complement. Med., 2012, 2(2), 84-95.
[http://dx.doi.org/10.1016/S2225-4110(16)30081-5] [PMID: 24716120]
[28]
Yap, Y.H.; Tan, N.; Fung, S.; Aziz, A.A.; Tan, C.; Ng, S. Nutrient composition, antioxidant properties, and anti-proliferative activity of Lignosus rhinocerus Cooke sclerotium. J. Sci. Food Agric., 2013, 93(12), 2945-2952.
[http://dx.doi.org/10.1002/jsfa.6121] [PMID: 23460242]
[29]
Zaila, S.; Zuraina, F.; Norfazlina, M.; Lek Mun, L.; Nurshahirah, N.; Florinsiah, L.; Rajab, N.F. Antiproliferative effect of Lignosus rhinocerotis, the tiger milk mushroom on HCT116 human colorectal cancer cells. Open Conf. Proc, 2013, pp. S65-S70.
[30]
Galor, S.; Yuen, J.; Buswell, J.A.; Benzie, I.F. Ganoderma lucidum (Lingzhi or Reishi) A Medicinal Mushroom. Herbal Medicine: Biomolecular and Clinical Aspects; Benzie, I.F.F; Galor, S.W., Ed.; CRC Press/Taylor & Francis: Boca Raton, FL, 2011.
[31]
Hsu, S.C.; Ou, C.C.; Li, J.W.; Chuang, T.C.; Kuo, H.P.; Liu, J.Y.; Chen, C.S.; Lin, S.C.; Su, C.H.; Kao, M.C. Ganoderma tsugae extracts inhibit colorectal cancer cell growth via G(2)/M cell cycle arrest. J. Ethnopharmacol., 2008, 120(3), 394-401.
[http://dx.doi.org/10.1016/j.jep.2008.09.025] [PMID: 18951965]
[32]
Mondal, S.; Chakraborty, I.; Rout, D.; Islam, S.S. Isolation and structural elucidation of a water-soluble polysaccharide (PS-I) of a wild edible mushroom, Termitomyces striatus. Carbohydr. Res., 2006, 341(7), 878-886.
[http://dx.doi.org/10.1016/j.carres.2006.02.004] [PMID: 16516873]
[33]
Wu, B.; Cui, J.; Zhang, C.; Li, Z. A polysaccharide from Agaricus blazei inhibits proliferation and promotes apoptosis of osteosarcoma cells. Int. J. Biol. Macromol., 2012, 50(4), 1116-1120.
[http://dx.doi.org/10.1016/j.ijbiomac.2012.02.023] [PMID: 22390851]
[34]
Lemieszek, M.K.; Langner, E.; Kaczor, J.; Kandefer-Szerszeń, M.; Sanecka, B.; Mazurkiewicz, W.; Rzeski, W. Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilát (Aphyllophoromycetideae): in vitro studies. Int. J. Med. Mushrooms, 2011, 13(2), 131-143.
[http://dx.doi.org/10.1615/IntJMedMushr.v13.i2.50] [PMID: 22135889]
[35]
Biziulevicius, G.A.; Vaitkuviene, A. Taking advantage of the experience in ethnomedicinal use of mushrooms: Anti-inflammatory and related pharmacological activities of fly agaric (Amanita muscaria) ethanolic extract deserve a modern evaluation. Med. Hypotheses, 2007, 69(4), 946-947.
[http://dx.doi.org/10.1016/j.mehy.2007.01.025] [PMID: 17329033]
[36]
Rao, Y.K.; Fang, S.H.; Wu, W.S.; Tzeng, Y.M. Constituents isolated from Cordyceps militaris suppress enhanced inflammatory mediator’s production and human cancer cell proliferation. J. Ethnopharmacol., 2010, 131(2), 363-367.
[http://dx.doi.org/10.1016/j.jep.2010.07.020] [PMID: 20633630]
[37]
Coetzee, J.C.; Wyk, A.E. The genus Calvatia (‘Gasteromycetes’, Lycoperdaceae): A review of its ethnomycology and biotechnological potential. Afr. J. Biotechnol., 2009, 8(22), 6007-6015.
[http://dx.doi.org/10.5897/AJB09.360]
[38]
Okigbo, R.N.; Nwatu, C.M. Ethnostudy and usage of edible and medicinal mushrooms in some parts of Anambra State, Nigeria. Nat. Resour., 2015, 6(01), 79-89.
[http://dx.doi.org/10.4236/nr.2015.61008]
[39]
Namita, P.; Mukesh, R. medicinal plants used as antimicrobial agents: A review. Int. Res. J. Pharm., 2012, 3(1), 31-40.
[40]
Lindequist, U.; Niedermeyer, T.H.; Jülich, W.D. The pharmacological potential of mushrooms. Evid. Based Complement. Alternat. Med., 2005, 2(3), 285-299.
[http://dx.doi.org/10.1093/ecam/neh107] [PMID: 16136207]
[41]
Ren, W.; Liu, Y.; Wan, S.; Fei, C.; Wang, W.; Chen, Y.; Zhang, Z.; Wang, T.; Wang, J.; Zhou, L.; Weng, Y.; He, T.; Zhang, Y. BMP9 inhibits proliferation and metastasis of HER2-positive SK-BR-3 breast cancer cells through ERK1/2 and PI3K/AKT pathways. PLoS One, 2014, 9(5), e96816.
[http://dx.doi.org/10.1371/journal.pone.0096816] [PMID: 24805814]
[42]
Sánchez, C. Reactive oxygen species and antioxidant properties from mushrooms. Synth. Syst. Biotechnol., 2016, 2(1), 13-22.
[http://dx.doi.org/10.1016/j.synbio.2016.12.001] [PMID: 29062957]
[43]
Yang, H.L.; Lin, K.Y.; Juan, Y.C.; Kumar, K.J.; Way, T.D.; Shen, P.C.; Chen, S.C.; Hseu, Y.C. The anti-cancer activity of Antrodia camphorata against human ovarian carcinoma (SKOV-3) cells via modulation of HER-2/neu signaling pathway. J. Ethnopharmacol., 2013, 148(1), 254-265.
[http://dx.doi.org/10.1016/j.jep.2013.04.023] [PMID: 23619020]
[44]
Liu, F.C.; Lai, M.T.; Chen, Y.Y.; Lin, W.H.; Chang, S.J.; Sheu, M.J.; Wu, C.H. Elucidating the inhibitory mechanisms of the ethanolic extract of the fruiting body of the mushroom Antrodia cinnamomea on the proliferation and migration of murine leukemia WEHI-3 cells and their tumorigenicity in a BALB/c allograft tumor model. Phytomedicine, 2013, 20(10), 874-882.
[http://dx.doi.org/10.1016/j.phymed.2013.03.008] [PMID: 23611488]
[45]
Asatiani, M.D.; Wasser, S.P.; Nevo, E.; Ruimi, N.; Mahajna, J.; Reznick, A.Z. The Shaggy Inc Cap medicinal mushroom, Coprinus comatus (O.F.Mull.: Fr.) Pers. (Agaricomycetideae) substances interfere with H2O2 induction of the NF-kappaB pathway through inhibition of Ikappaalpha phosphorylation in MCF7 breast cancer cells. Int. J. Med. Mushrooms, 2011, 13(1), 19-25.
[http://dx.doi.org/10.1615/IntJMedMushr.v13.i1.30] [PMID: 22135900]
[46]
Ruimi, N.; Petrova, R.D.; Agbaria, R.; Sussan, S.; Wasser, S.P.; Reznick, A.Z.; Mahajna, J. Inhibition of TNFα-induced iNOS expression in HSV-tk transduced 9L glioblastoma cell lines by Marasmius oreades substances through NF-κB- and MAPK-dependent mechanisms. Mol. Biol. Rep., 2010, 37(8), 3801-3812.
[http://dx.doi.org/10.1007/s11033-010-0035-0] [PMID: 20224909]
[47]
Petrova, R.D.; Mahajna, J.; Reznick, A.Z.; Wasser, S.P.; Denchev, C.M.; Nevo, E. Fungal substances as modulators of NF-kappaB activation pathway. Mol. Biol. Rep., 2007, 34(3), 145-154.
[http://dx.doi.org/10.1007/s11033-006-9027-5] [PMID: 17094008]
[48]
Mizuno, T. The extraction and development of antitumour-active polysaccharides from medicinal mushrooms in Japan. Int. J. Med. Mushrooms, 1999, 1(1), 9-29.
[http://dx.doi.org/10.1615/IntJMedMushrooms.v1.i1.20]
[49]
Mahajna, J.; Dotan, N.; Zaidman, B.Z.; Petrova, R.D.; Wasser, S.P. Pharmacological values of medicinal mushrooms for prostate cancer therapy: The case of Ganoderma lucidum. Nutr. Cancer, 2009, 61(1), 16-26.
[http://dx.doi.org/10.1080/01635580802379323] [PMID: 19116872]
[50]
Zaidman, B.Z.; Wasser, S.P.; Nevo, E.; Mahajna, J. Coprinus comatus and Ganoderma lucidum interfere with androgen receptor function in LNCaP prostate cancer cells. Mol. Biol. Rep., 2008, 35(2), 107-117.
[http://dx.doi.org/10.1007/s11033-007-9059-5] [PMID: 17431821]
[51]
Suárez-Arroyo, I.J.; Loperena-Alvarez, Y.; Rosario-Acevedo, R.; Martínez-Montemayor, M.M. Ganoderma spp.: A promising adjuvant treatment for breast cancer. Medicines (Basel), 2017, 4(1), 15.
[http://dx.doi.org/10.3390/medicines4010015] [PMID: 28758107]
[52]
Lull, C.; Wichers, H.J.; Savelkoul, H.F. Antiinflammatory and immunomodulating properties of fungal metabolites. Mediators Inflamm., 2005, 2005(2), 63-80.
[http://dx.doi.org/10.1155/MI.2005.63] [PMID: 16030389]
[53]
Park, C.; Hong, S.H.; Lee, J.Y.; Kim, G.Y.; Choi, B.T.; Lee, Y.T.; Park, D.I.; Park, Y.M.; Jeong, Y.K.; Choi, Y.H. Growth inhibition of U937 leukemia cells by aqueous extract of Cordyceps militaris through induction of apoptosis. Oncol. Rep., 2005, 13(6), 1211-1216.
[http://dx.doi.org/10.3892/or.13.6.1211] [PMID: 15870944]
[54]
Harhaji Trajković, L.M.; Mijatović, S.A.; Maksimović-Ivanić, D.D.; Stojanović, I.D.; Momcilović, M.B.; Tufegdzić, S.J.; Maksimović, V.M.; Marjanović, Z.S.; Stosić-Grujicić, S.D. Anticancer properties of Ganoderma lucidum methanol extracts in vitro and in vivo. Nutr. Cancer, 2009, 61(5), 696-707.
[http://dx.doi.org/10.1080/01635580902898743] [PMID: 19838944]
[55]
Yassin, M.; Mahajna, J.A.; Wasser, S.P. submerged cultured mycelium extracts of higher basidiomycetes mushrooms selectively inhibit proliferation and induce differentiation of K562 human chronic myelogenous leukemia cells. Int. J. Med. Mushrooms, 2003, 5(3), 1-16.
[http://dx.doi.org/10.1615/InterJMedicMush.v5.i3.40]
[56]
Chen, Y.J.; Shiao, M.S.; Lee, S.S.; Wang, S.Y. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Life Sci., 1997, 60(25), 2349-2359.
[http://dx.doi.org/10.1016/S0024-3205(97)00291-9] [PMID: 9194691]
[57]
Grube, B.J.; Eng, E.T.; Kao, Y.C.; Kwon, A.; Chen, S. White button mushroom phytochemicals inhibit aromatase activity and breast cancer cell proliferation. J. Nutr., 2001, 131(12), 3288-3293.
[http://dx.doi.org/10.1093/jn/131.12.3288] [PMID: 11739882]
[58]
Younis, A.; Stewart, J.; Wu, F.S.; El Shikh, H.; Hassan, F.; Elaasser, M. Cytotoxic activity of edible mushrooms extracts against tumor cell lines. Int. J. Sci. Technol., 2014, 3(11), 736-749.
[59]
Spiotto, M.T.; Chung, T.D. STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cells. Prostate, 2000, 42(3), 186-195. 10.1002/(SICI)1097-0045(20000215)42:3&186: AID-PROS4&3.0.CO;2-E
[PMID: 10639189]
[60]
Song, F.Q.; Liu, Y.; Kong, X.S.; Chang, W.; Song, G. Progress on understanding the anticancer mechanisms of medicinal mushroom: inonotus obliquus. Asian Pac. J. Cancer Prev., 2013, 14(3), 1571-1578.
[http://dx.doi.org/10.7314/APJCP.2013.14.3.1571] [PMID: 23679238]
[61]
Takei, T.; Yoshida, M.; Ohnishi-Kameyama, M.; Kobori, M. Ergosterol peroxide, an apoptosis-inducing component isolated from Sarcodon aspratus (Berk.). S. Ito. Biosci. Biotechnol. Biochem., 2005, 69(1), 212-215.
[http://dx.doi.org/10.1271/bbb.69.212] [PMID: 15665489]
[62]
Yang, C.H.; Kao, Y.H.; Huang, K.S.; Wang, C.Y.; Lin, L.W. Cordyceps militaris and mycelial fermentation induced apoptosis and autophagy of human glioblastoma cells. Cell Death Dis., 2012, 3(11), e431.
[http://dx.doi.org/10.1038/cddis.2012.172] [PMID: 23190603]
[63]
Vento, M.T.; Zazzu, V.; Loffreda, A.; Cross, J.R.; Downward, J.; Stoppelli, M.P.; Iaccarino, I. Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells. PLoS One, 2010, 5(12), e15636.
[http://dx.doi.org/10.1371/journal.pone.0015636] [PMID: 21203533]
[64]
Zhao, W.; Xu, J.W.; Zhong, J.J. Enhanced production of ganoderic acids in static liquid culture of Ganoderma lucidum under nitrogen-limiting conditions. Bioresour. Technol., 2011, 102(17), 8185-8190.
[http://dx.doi.org/10.1016/j.biortech.2011.06.043] [PMID: 21742489]
[65]
Younis, A.M. Anticancer potential of Hericium erinaceus extracts against particular human cancer cell lines. Microb. Biosyst, 2017, 2(1), 9-20.
[http://dx.doi.org/10.21608/mb.2017.5253]
[66]
Heleno, S.A.; Barros, L.; Martins, A.; Queiroz, M.J.R.; Morales, P.; Fernández-Ruiz, V.; Ferreira, I.C. Chemical composition, antioxidant activity and bioaccessibility studies in phenolic extracts of two Hericium wild edible species. Lebensm. Wiss. Technol., 2015, 63(1), 475-481.
[http://dx.doi.org/10.1016/j.lwt.2015.03.040]
[67]
Talorete, T.P.; Isoda, H.; Maekawa, T. Agaricus blazei (class Basidiomycotina) aqueous extract enhances the expression of c-Jun protein in MCF7 cells. J. Agric. Food Chem., 2002, 50(18), 5162-5166.
[http://dx.doi.org/10.1021/jf011566p] [PMID: 12188624]
[68]
Leffingwell, J.C.; Alford, E.D. Volatile constituents of the giant puffball mushroom (Calvatia gigantea). Leffingwell Rep., 2011, 4, 1-17.
[69]
Ren, G.; Zhao, Y.P.; Yang, L.; Fu, C.X. Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis. Cancer Lett., 2008, 262(2), 190-200.
[http://dx.doi.org/10.1016/j.canlet.2007.12.013] [PMID: 18222036]
[70]
Park, S.E.; Yoo, H.S.; Jin, C.Y.; Hong, S.H.; Lee, Y.W.; Kim, B.W.; Lee, S.H.; Kim, W.J.; Cho, C.K.; Choi, Y.H. Induction of apoptosis and inhibition of telomerase activity in human lung carcinoma cells by the water extract of Cordyceps militaris. Food Chem. Toxicol., 2009, 47(7), 1667-1675.
[http://dx.doi.org/10.1016/j.fct.2009.04.014] [PMID: 19393284]
[71]
Hsieh, T.C.; Kunicki, J.; Darzynkiewicz, Z.; Wu, J.M. Effects of extracts of Coriolus versicolor (I’m-Yunity) on cell-cycle progression and expression of interleukins-1 beta,-6, and -8 in promyelocytic HL-60 leukemic cells and mitogenically stimulated and nonstimulated human lymphocytes. J. Altern. Complement. Med., 2002, 8(5), 591-602.
[http://dx.doi.org/10.1089/107555302320825101] [PMID: 12470440]
[72]
Wang, C.R.; Ng, T.B.; Li, L.; Fang, J.C.; Jiang, Y.; Wen, T.Y.; Qiao, W.T.; Li, N.; Liu, F. Isolation of a polysaccharide with antiproliferative, hypoglycemic, antioxidant and HIV-1 reverse transcriptase inhibitory activities from the fruiting bodies of the abalone mushroom Pleurotus abalonus. J. Pharm. Pharmacol., 2011, 63(6), 825-832.
[http://dx.doi.org/10.1111/j.2042-7158.2011.01274.x] [PMID: 21585381]
[73]
Cao, Q.Z.; Lin, Z.B. Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell. Life Sci., 2006, 78(13), 1457-1463.
[http://dx.doi.org/10.1016/j.lfs.2005.07.017] [PMID: 16269156]
[74]
Palazon, A.; Tyrakis, P.A.; Macias, D.; Veliça, P.; Rundqvist, H.; Fitzpatrick, S.; Vojnovic, N.; Phan, A.T.; Loman, N.; Hedenfalk, I.; Hatschek, T.; Lövrot, J.; Foukakis, T.; Goldrath, A.W.; Bergh, J. Johnson, R.S. an hif-1α/vegf-a axis in cytotoxic T cells regulates tumor progression. Cancer Cell, 2017, 32(5), 669-683.e5.
[http://dx.doi.org/10.1016/j.ccell.2017.10.003] [PMID: 29136509]
[75]
Stanley, G.; Harvey, K.; Slivova, V.; Jiang, J.; Sliva, D. Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells. Biochem. Biophys. Res. Commun., 2005, 330(1), 46-52.
[http://dx.doi.org/10.1016/j.bbrc.2005.02.116] [PMID: 15781230]
[76]
Xu, J.; Yuan, Q.G.; Luo, P.; Sun, X.; Ma, J.C. Pleurotus eous polysaccharides suppress angiogenesis and induce apoptosis via ROS-dependent JNK activation and mitochondrial mediated mechanisms in MCF-7 human breast cancer cells. Bangladesh J. Pharmacol., 2015, 10(1), 78-86.
[http://dx.doi.org/10.3329/bjp.v10i1.21153]
[77]
Chen, S.C.; Lu, M.K.; Cheng, J.J.; Wang, D.L. Antiangiogenic activities of polysaccharides isolated from medicinal fungi. FEMS Microbiol. Lett., 2005, 249(2), 247-254.
[http://dx.doi.org/10.1016/j.femsle.2005.06.033] [PMID: 16046081]
[78]
Yang, W.; Pei, F.; Shi, Y.; Zhao, L.; Fang, Y.; Hu, Q. Purification, characterization and anti-proliferation activity of polysaccharides from Flammulina velutipes. Carbohydr. Polym., 2012, 88(2), 474-480.
[http://dx.doi.org/10.1016/j.carbpol.2011.12.018]
[79]
Paterson, R.R.M. Cordyceps: A traditional Chinese medicine and another fungal therapeutic biofactory? Phytochemistry, 2008, 69(7), 1469-1495.
[http://dx.doi.org/10.1016/j.phytochem.2008.01.027] [PMID: 18343466]
[80]
Xu, W.; Huang, J.J.H.; Cheung, P.C.K. Extract of Pleurotus pulmonarius suppresses liver cancer development and progression through inhibition of VEGF-induced PI3K/AKT signaling pathway. PLoS One, 2012, 7(3), e34406.
[http://dx.doi.org/10.1371/journal.pone.0034406] [PMID: 22470568]
[81]
Park, Y.M.; Kim, I.T.; Park, H.J.; Choi, J.W.; Park, K.Y.; Lee, J.D.; Nam, B.H.; Kim, D.G.; Lee, J.Y.; Lee, K.T. Anti-inflammatory and anti-nociceptive effects of the methanol extract of Fomes fomentarius. Biol. Pharm. Bull., 2004, 27(10), 1588-1593.
[http://dx.doi.org/10.1248/bpb.27.1588] [PMID: 15467201]
[82]
Konno, S.; Aynehchi, S.; Dolin, D.J.; Schwartz, A.M.; Choudhury, M.S.; Tazaki, H. Anticancer and hypoglycemic effects of polysaccharides in edible and medicinal Maitake mushroom. Int. J. Med. Mushrooms, 2002, 4(3), 11.
[83]
Liu, Y.W.; Gao, J.L.; Guan, J.; Qian, Z.M.; Feng, K.; Li, S.P. Evaluation of antiproliferative activities and action mechanisms of extracts from two species of Ganoderma on tumor cell lines. J. Agric. Food Chem., 2009, 57(8), 3087-3093.
[http://dx.doi.org/10.1021/jf900011f] [PMID: 19368349]
[84]
Taofiq, O.; Martins, A.; Barreiro, M.F.; Ferreira, I.C. Anti-inflammatory potential of mushroom extracts and isolated metabolites. Trends Food Sci. Technol., 2016, 50, 193-210.
[http://dx.doi.org/10.1016/j.tifs.2016.02.005]
[85]
Gooday, G.W.; Zerning, J. Ileodictyon cibarium: The basket fungus as a buckyball. Mycologist, 1997, 11(4), 184-186.
[http://dx.doi.org/10.1016/S0269-915X(97)80105-X]
[86]
Paterson, R.R.M.; Lima, N. Biomedical effects of mushrooms with emphasis on pure compounds. Biomed. J., 2014, 37(6), 357-368.
[http://dx.doi.org/10.4103/2319-4170.143502] [PMID: 25355390]
[87]
Gao, X.; Deeb, D.; Hao, J.; Liu, Y.; Arbab, A.S.; Dulchavsky, S.A.; Gautam, S.C. Synthetic triterpenoids inhibit growth, induce apoptosis and suppress pro-survival Akt, mTOR and NF-κB signaling proteins in colorectal cancer cells. Anticancer Res., 2010, 30(3), 785-792.
[PMID: 20392997]
[88]
Zhang, M.; Cheung, P.C.; Zhang, L.; Chiu, C.M.; Ooi, V.E. Carboxymethylated β-glucan from mushroom sclerotium of Pleurotus tuber-regium as novel water-soluble anti-tumor agent. Carbohydr. Polym., 2004, 57(3), 319-325.
[http://dx.doi.org/10.1016/j.carbpol.2004.05.008]
[89]
Pagliacci, M.C.; Fumi, G.; Migliorati, G.; Grignani, F.; Riccardi, C.; Nicoletti, I. Cytostatic and cytotoxic effects of tumor necrosis factor alpha on MCF-7 human breast tumor cells are differently inhibited by glucocorticoid hormones. Lymphokine Cytokine Res., 1993, 12(6), 439-447.
[PMID: 8123760]
[90]
Sharif, S.; Atta, A.; Huma, T.; Shah, A.A.; Afzal, G.; Rashid, S.; Shahid, M.; Mustafa, G. Anticancer, antithrombotic, antityrosinase, and anti-α-glucosidase activities of selected wild and commercial mushrooms from Pakistan. Food Sci. Nutr., 2018, 6(8), 2170-2176.
[http://dx.doi.org/10.1002/fsn3.781] [PMID: 30510718]
[91]
Rossiana, N.; Nur, A.A.; Mayawatie, B.; Andayaningsih, P. Cytotoxicity assay of ethyl acetate extract shimeji (Lyophyllum shimeji (Kawam.) Hongo) and white oyster mushroom (Pleurotus ostreatus Jacq.) against HCT-116 cell line. IOP Conf. Series: Earth and Environmental Science, 2018, Vol 197, p. 012007.
[http://dx.doi.org/10.1088/1755-1315/197/1/012007]
[92]
Chan, J.S.L.; Asatiani, M.D.; Sharvit, L.E.; Trabelcy, B.; Barseghyan, G.S.; Wasser, S.P. Chemical composition and medicinal value of the new Ganoderma tsugae var. jannieae CBS-120304 medicinal higher basidiomycete mushroom. Int. J. Med. Mushrooms, 2015, 17(8), 735-747.
[http://dx.doi.org/10.1615/IntJMedMushrooms.v17.i8.40] [PMID: 26559860]
[93]
Friedman, M. Mushroom polysaccharides: Chemistry and antiobesity, antidiabetes, anticancer, and antibiotic properties in cells, rodents, and humans. Foods, 2016, 5(4), 80.
[http://dx.doi.org/10.3390/foods5040080] [PMID: 28231175]
[94]
Thiery, J.P.; Acloque, H.; Huang, R.Y.; Nieto, M.A. Epithelial-mesenchymal transitions in development and disease. Cell, 2009, 139(5), 871-890.
[http://dx.doi.org/10.1016/j.cell.2009.11.007] [PMID: 19945376]
[95]
Kumar, K.J.; Vani, M.G.; Chueh, P.J.; Mau, J.L.; Wang, S.Y.; Antrodin, C. Antrodin C inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via suppression of Smad2/3 and β-catenin signaling pathways. PLoS One, 2015, 10(2), e0117111.
[http://dx.doi.org/10.1371/journal.pone.0117111] [PMID: 25658913]
[96]
Vleminckx, K.; Vakaet, L., Jr; Mareel, M.; Fiers, W.; van Roy, F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell, 1991, 66(1), 107-119.
[http://dx.doi.org/10.1016/0092-8674(91)90143-M] [PMID: 2070412]
[97]
Blechschmidt, K.; Sassen, S.; Schmalfeldt, B.; Schuster, T.; Höfler, H.; Becker, K.F. The E-cadherin repressor Snail is associated with lower overall survival of ovarian cancer patients. Br. J. Cancer, 2008, 98(2), 489-495.
[http://dx.doi.org/10.1038/sj.bjc.6604115] [PMID: 18026186]
[98]
Singh, S.K.; Clarke, I.D.; Hide, T.; Dirks, P.B. Cancer stem cells in nervous system tumors. Oncogene, 2004, 23(43), 7267-7273.
[http://dx.doi.org/10.1038/sj.onc.1207946] [PMID: 15378086]
[99]
Fruman, D.A.; Rommel, C. PI3K and cancer: Lessons, challenges and opportunities. Nat. Rev. Drug Discov., 2014, 13(2), 140-156.
[http://dx.doi.org/10.1038/nrd4204] [PMID: 24481312]
[100]
Nagle, D.G.; Zhou, Y.D. Natural product-based inhibitors of hypoxia-inducible factor-1 (HIF-1). Curr. Drug Targets, 2006, 7(3), 355-369.
[http://dx.doi.org/10.2174/138945006776054979] [PMID: 16515532]
[101]
Singh, M.; Tulsawani, R.; Koganti, P.; Chauhan, A.; Manickam, M.; Misra, K. Cordyceps sinensis increases hypoxia tolerance by inducing heme oxygenase-1 and metallothionein via Nrf2 activation in human lung epithelial cells. BioMed Res. Int., 2013, 2013, 569206.
[102]
Qing, G.; Simon, M.C. Hypoxia inducible factor-2alpha: A critical mediator of aggressive tumor phenotypes. Curr. Opin. Genet. Dev., 2009, 19(1), 60-66.
[http://dx.doi.org/10.1016/j.gde.2008.12.001] [PMID: 19167211]
[103]
Thyagarajan, A.; Jedinak, A.; Nguyen, H.; Terry, C.; Baldridge, L.A.; Jiang, J.; Sliva, D. Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK). Nutr. Cancer, 2010, 62(5), 630-640.
[http://dx.doi.org/10.1080/01635580903532390] [PMID: 20574924]
[104]
Reis, F.S.; Lima, R.T.; Morales, P.; Ferreira, I.C.; Vasconcelos, M.H. Methanolic extract of Ganoderma lucidum induces autophagy of AGS human gastric tumor cells. Molecules, 2015, 20(10), 17872-17882.
[http://dx.doi.org/10.3390/molecules201017872] [PMID: 26426001]
[105]
Wang, Y.; Xu, G.; Tang, X.; Chen, H. Polysaccharide lentinan extracted from the stipe of Lentinus edodes mushroom exerts anticancer activities through the transcriptional regulation of cell cycle progression and metastatic markers in human colon cancer cells. FASEB J., 2017, 31(1), lb391-lb391.
[106]
Wang, J.; Li, W.; Huang, X.; Liu, Y.; Li, Q.; Zheng, Z.; Wang, K. A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice. Oncotarget, 2017, 8(1), 610-623.
[http://dx.doi.org/10.18632/oncotarget.13481] [PMID: 27888812]
[107]
Klonisch, T.; Wiechec, E.; Hombach-Klonisch, S.; Ande, S.R.; Wesselborg, S.; Schulze-Osthoff, K.; Los, M. Cancer stem cell markers in common cancers - therapeutic implications. Trends Mol. Med., 2008, 14(10), 450-460.
[http://dx.doi.org/10.1016/j.molmed.2008.08.003] [PMID: 18775674]
[108]
Luk, S.U.; Lee, T.K.W.; Liu, J.; Lee, D.T.W.; Chiu, Y.T.; Ma, S.; Ng, I.O.L.; Wong, Y.C.; Chan, F.L.; Ling, M.T. Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population. PLoS One, 2011, 6(5), e19804.
[http://dx.doi.org/10.1371/journal.pone.0019804] [PMID: 21603625]
[109]
Lee, S.H.; Hwang, H.S.; Yun, J.W. Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells. Phytother. Res., 2009, 23(12), 1784-1789.
[http://dx.doi.org/10.1002/ptr.2836] [PMID: 19367670]
[110]
Shin, A.; Kim, J.; Lim, S.Y.; Kim, G.; Sung, M.K.; Lee, E.S.; Ro, J. Dietary mushroom intake and the risk of breast cancer based on hormone receptor status. Nutr. Cancer, 2010, 62(4), 476-483.
[http://dx.doi.org/10.1080/01635580903441212] [PMID: 20432168]
[111]
De Veirman, K.; Rao, L.; De Bruyne, E.; Menu, E.; Van Valckenborgh, E.; Van Riet, I.; Frassanito, M.A.; Di Marzo, L.; Vacca, A.; Vanderkerken, K. Cancer associated fibroblasts and tumor growth: focus on multiple myeloma. Cancers (Basel), 2014, 6(3), 1363-1381.
[http://dx.doi.org/10.3390/cancers6031363] [PMID: 24978438]
[112]
Vadlakonda, L.; Pasupuleti, M.; Pallu, R. Role of PI3K-AKT-mTOR and Wnt signaling pathways in transition of G1-S phase of cell cycle in cancer cells. Front. Oncol., 2013, 3, 85.
[http://dx.doi.org/10.3389/fonc.2013.00085] [PMID: 23596569]
[113]
Kim, J.W.; Kim, H.I.; Kim, J.H.; Kwon, O.C.; Son, E.S.; Lee, C.S.; Park, Y.J. Effects of ganodermanondiol, a new melanogenesis inhibitor from the medicinal mushroom Ganoderma lucidum. Int. J. Mol. Sci., 2016, 17(11), 1798.
[http://dx.doi.org/10.3390/ijms17111798] [PMID: 27801787]
[114]
Suarez-Arroyo, I.J.; Rosario-Acevedo, R.; Aguilar-Perez, A.; Clemente, P.L.; Cubano, L.A.; Serrano, J.; Schneider, R.J.; Martínez-Montemayor, M.M. Anti-tumor effects of Ganoderma lucidum (reishi) in inflammatory breast cancer in in vivo and in vitro models. PLoS One, 2013, 8(2), e57431.
[http://dx.doi.org/10.1371/journal.pone.0057431] [PMID: 23468988]
[115]
Bell, E.; Taylor, M.A. Functional roles for exosomal microRNAS in the tumour microenvironment. Comput. Struct. Biotechnol. J., 2016, 15, 8-13.
[http://dx.doi.org/10.1016/j.csbj.2016.10.005] [PMID: 27872688]
[116]
Vitak, T.; Yurkiv, B.; Wasser, S.; Nevo, E.; Sybirna, N. Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus. World J. Diabetes, 2017, 8(5), 187-201.
[http://dx.doi.org/10.4239/wjd.v8.i5.187] [PMID: 28572880]
[117]
Casey, S.C.; Vaccari, M.; Mulla, F.; Temaimi, R.; Amedei, A.; Barcellos-Hoff, M.H.; Brown, D.G.; Chapellier, M.; Christopher, J.; Curran, C.S.; Forte, S. The effect of environmental chemicals on the tumor microenvironment. Carcinogenesis, 2015, 36(1), S160-S183.
[http://dx.doi.org/10.1093/carcin/bgv035]
[118]
Valdespino-Gómez, V.M.; Valdespino-Castillo, P.M.; Valdespino-Castillo, V.E. Cell signaling pathways interaction in cellular proliferation: Potential target for therapeutic interventionism. Cir. Cir., 2015, 83(2), 165-174.
[PMID: 25986976]
[119]
Fullerton, S.A.; Samadi, A.A.; Tortorelis, D.G.; Choudhury, M.S.; Mallouh, C.; Tazaki, H.; Konno, S. Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide). Mol. Urol., 2000, 4(1), 7-13.
[PMID: 10851301]
[120]
Fang, N.; Li, Q.; Yu, S.; Zhang, J.; He, L.; Ronis, M.J.; Badger, T.M. Inhibition of growth and induction of apoptosis in human cancer cell lines by an ethyl acetate fraction from shiitake mushrooms. J. Altern. Complement. Med., 2006, 12(2), 125-132.
[http://dx.doi.org/10.1089/acm.2006.12.125] [PMID: 16566671]
[121]
Ye, M.; Liu, J.K.; Lu, Z.X.; Zhao, Y.; Liu, S.F.; Li, L.L.; Tan, M.; Weng, X.X.; Li, W.; Cao, Y. Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro. FEBS Lett., 2005, 579(16), 3437-3443.
[http://dx.doi.org/10.1016/j.febslet.2005.05.013] [PMID: 15949805]
[122]
Krishnapriya, P.J.; Geetha, K.T. Proximate constitution and antiproliferative activity of Pleurotus opuntiae (Durieu and Lev.) Sacc. against Colon Cancer. Int. J. Curr. Microbiol. Appl. Sci., 2017, 6, 1406-1414.
[http://dx.doi.org/10.20546/ijcmas.2017.605.153]
[123]
Fox, C.; Yau, R.; Choudhury, M.; Phillips, J.L.; Konno, S. Anticancer effect of medicinal mushroom with prooxidant activity on human bladder cancer cells. J. Cancer Res. Treat., 2018, 6(2), 54-59.
[http://dx.doi.org/10.12691/jcrt-6-2-5]
[124]
Kim, K.H.; Moon, E.; Choi, S.U.; Kim, S.Y.; Lee, K.R. Lanostane triterpenoids from the mushroom Naematoloma fasciculare. J. Nat. Prod., 2013, 76(5), 845-851.
[http://dx.doi.org/10.1021/np300801x] [PMID: 23634786]
[125]
Wasser, S.P. Medicinal mushroom science: Current perspectives, advances, evidences, and challenges. Biomed. J., 2014, 37(6), 345-356.
[http://dx.doi.org/10.4103/2319-4170.138318] [PMID: 25179726]
[126]
Tang, W.; Liu, J.W.; Zhao, W.M.; Wei, D.Z.; Zhong, J.J. Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci., 2006, 80(3), 205-211.
[http://dx.doi.org/10.1016/j.lfs.2006.09.001] [PMID: 17007887]
[127]
Chen, N.H.; Liu, J.W.; Zhong, J.J. Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression. Pharmacol. Rep., 2010, 62(1), 150-163.
[http://dx.doi.org/10.1016/S1734-1140(10)70252-8] [PMID: 20360625]
[128]
Rahi, D.K.; Malik, D. Diversity of mushrooms and their metabolites of nutraceutical and therapeutic significance. J. Mycol., 2016. Article ID 7654123.
[http://dx.doi.org/10.1155/2016/7654123]
[129]
Li, C.H.; Chen, P.Y.; Chang, U.M.; Kan, L.S.; Fang, W.H.; Tsai, K.S.; Lin, S.B. Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells. Life Sci., 2005, 77(3), 252-265.
[http://dx.doi.org/10.1016/j.lfs.2004.09.045] [PMID: 15878354]
[130]
Hyodo, I.; Amano, N.; Eguchi, K.; Narabayashi, M.; Imanishi, J.; Hirai, M.; Nakano, T.; Takashima, S. Nationwide survey on complementary and alternative medicine in cancer patients in Japan. J. Clin. Oncol., 2005, 23(12), 2645-2654.
[http://dx.doi.org/10.1200/JCO.2005.04.126] [PMID: 15728227]
[131]
Harttig, U.; Anke, T.; Scherer, A.; Steglich, W. Leaianafulvene a sesquiterpenoid fulvene derivative from cultures of Mycena leaiana. Phytochemistry, 1990, 29(12), 3942-3944.
[http://dx.doi.org/10.1016/0031-9422(90)85368-P]
[132]
Akihisa, T.; Nakamura, Y.; Tokuda, H.; Uchiyama, E.; Suzuki, T.; Kimura, Y.; Uchikura, K.; Nishino, H. Triterpene acids from Poria cocos and their anti-tumor-promoting effects. J. Nat. Prod., 2007, 70(6), 948-953.
[http://dx.doi.org/10.1021/np0780001] [PMID: 17488130]
[133]
Nomura, M.; Takahashi, T.; Uesugi, A.; Tanaka, R.; Kobayashi, S. Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. Anticancer Res., 2008, 28(5A), 2691-2696.
[PMID: 19035296]
[134]
Shavit, E. Irofulven - Halloween trick or a beacon of light. Med. Mushrooms, 2009, 2008, 18-21.
[135]
Chen, Y.J.; Chen, C.C.; Huang, H.L. Induction of apoptosis by Armillaria mellea constituent armillarikin in human hepatocellular carcinoma. OncoTargets Ther., 2016, 9, 4773-4783.
[http://dx.doi.org/10.2147/OTT.S103940] [PMID: 27536140]
[136]
Norikura, T.; Fujiwara, K.; Yanai, T.; Sano, Y.; Sato, T.; Tsunoda, T.; Kushibe, K.; Todate, A.; Morinaga, Y.; Iwai, K.; Matsue, H. p-terphenyl derivatives from the mushroom Thelephora aurantiotincta suppress the proliferation of human hepatocellular carcinoma cells via iron chelation. J. Agric. Food Chem., 2013, 61(6), 1258-1264.
[http://dx.doi.org/10.1021/jf3041098] [PMID: 23339435]
[137]
Lu, C.; Huang, W.; Lee, K.; Lee, K.; Hsieh, M.; Huang, C.; Lee, L.; Lee, B.; Teng, C.; Shen, C.; Tung, S.; Kuo, H. Inhibitory effect of Erinacines A on the growth of DLD-1 colorectal cancer cells is induced by generation of reactive oxygen species and activation of p70S6K and p21. J. Funct. Foods, 2016, 21, 474-484.
[http://dx.doi.org/10.1016/j.jff.2015.12.031]
[138]
He, L.; Han, J.; Li, B.; Huang, L.; Ma, K.; Chen, Q.; Liu, X.; Bao, L.; Liu, H. Identification of a new cyathane diterpene that induces mitochondrial and autophagy-dependent apoptosis and shows a potent in vivo anti-colorectal cancer activity. Eur. J. Med. Chem., 2016, 111, 183-192.
[http://dx.doi.org/10.1016/j.ejmech.2016.01.056] [PMID: 26871659]
[139]
Kumar, S.; Pandey, A.K. Chemistry and biological activities of flavonoids: An overview. ScientificWorldJournal, 2013, 2013, 162750.
[http://dx.doi.org/10.1155/2013/162750] [PMID: 24470791]
[140]
Chen, Y.C.; Chang, H.Y.; Deng, J.S.; Chen, J.J.; Huang, S.S.; Lin, I.H.; Kuo, W.L.; Chao, W.; Huang, G.J. Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells. Am. J. Chin. Med., 2013, 41(6), 1439-1457.
[http://dx.doi.org/10.1142/S0192415X13500961] [PMID: 24228611]
[141]
Pennerman, K.K.; Yin, G.; Bennett, J.W. Health effects of small volatile compounds from East Asian medicinal mushrooms. Mycobiology, 2015, 43(1), 9-13.
[http://dx.doi.org/10.5941/MYCO.2015.43.1.9] [PMID: 25892909]
[142]
Mattila, P.; Könkö, K.; Eurola, M.; Pihlava, J.M.; Astola, J.; Vahteristo, L.; Hietaniemi, V.; Kumpulainen, J.; Valtonen, M.; Piironen, V. Contents of vitamins, mineral elements, and some phenolic compounds in cultivated mushrooms. J. Agric. Food Chem., 2001, 49(5), 2343-2348.
[http://dx.doi.org/10.1021/jf001525d] [PMID: 11368601]
[143]
Palacios, I.; Lozano, M.; Moro, C.; D’Arrigo, M.; Rostagno, M.A.; Martinez, J.A.; Garcia-Lafuente, A.; Guillamon, E.; Villares, A. Antioxidant properties of phenolic compounds occurring in edible mushrooms. Food Chem., 2011, 128(3), 674-678.
[http://dx.doi.org/10.1016/j.foodchem.2011.03.085]
[144]
Nakamura, M.; Kono, Y.; Takatsuki, A. Mepanipyrim, a novel inhibitor of pharmacologically induced Golgi dispersion. Biosci. Biotechnol. Biochem., 2003, 67(1), 139-150.
[http://dx.doi.org/10.1271/bbb.67.139] [PMID: 12619685]
[145]
Lee, S.R.; Jung, K.; Noh, H.J.; Park, Y.J.; Lee, H.L.; Lee, K.R.; Kang, K.S.; Kim, K.H. A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment. Bioorg. Med. Chem. Lett., 2015, 25(24), 5712-5715.
[http://dx.doi.org/10.1016/j.bmcl.2015.10.092] [PMID: 26547693]
[146]
Luo, X.; Li, N.; Zhong, J.; Tan, Z.; Liu, Y.; Dong, X.; Cheng, C.; Xu, Z.; Li, H.; Yang, L.; Tang, M.; Weng, X.; Yi, W.; Liu, J.; Cao, Y. Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1/LSF- MMP2/CD44 axes. Oncotarget, 2016, 7(42), 68708-68720.
[http://dx.doi.org/10.18632/oncotarget.11929] [PMID: 27626695]
[147]
Lin, H.C.; Lin, M.H.; Liao, J.H.; Wu, T.H.; Lee, T.H.; Mi, F.L.; Wu, C.H.; Chen, K.C.; Cheng, C.H.; Lin, C.W. Antroquinonol, a ubiquinone derivative from the mushroom Antrodia camphorata, inhibits colon cancer stem cell-like properties: Insights into the molecular mechanism and inhibitory targets. J. Agric. Food Chem., 2017, 65(1), 51-59.
[http://dx.doi.org/10.1021/acs.jafc.6b04101] [PMID: 27997180]
[148]
Schulzova, V.; Hajslova, J.; Peroutka, R.; Hlavasek, J.; Gry, J.; Andersson, H.C. Agaritine content of 53 Agaricus species collected from nature. Food Addit. Contam. Part A Chem. Anal. Control Expo. Risk Assess., 2009, 26(1), 82-93.
[http://dx.doi.org/10.1080/02652030802039903] [PMID: 19680875]
[149]
Lin, Y.W.; Chiang, B.H. 4-acetylantroquinonol B isolated from Antrodia cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels. J. Agric. Food Chem., 2011, 59(16), 8625-8631.
[http://dx.doi.org/10.1021/jf2011326] [PMID: 21739974]
[150]
Petrova, R.D.; Reznick, A.Z.; Wasser, S.P.; Denchev, C.M.; Nevo, E.; Mahajna, J. Fungal metabolites modulating NF-kappaB activity: an approach to cancer therapy and chemoprevention (review). Oncol. Rep., 2008, 19(2), 299-308.
[PMID: 18202775]
[151]
Russo, A.; Piovano, M.; Clericuzio, M.; Lombardo, L.; Tabasso, S.; Chamy, M.C.; Vidari, G.; Cardile, V.; Vita-Finzi, P.; Garbarino, J.A. Putrescine-1,4-dicinnamide from Pholiota spumosa (Basidiomycetes) inhibits cell growth of human prostate cancer cells. Phytomedicine, 2007, 14(2-3), 185-191.
[http://dx.doi.org/10.1016/j.phymed.2006.09.010] [PMID: 17085028]
[152]
Sun, F.; Zheng, X.Y.; Ye, J.; Wu, T.T.; Wang, Jl.; Chen, W. Potential anticancer activity of myricetin in human T24 bladder cancer cells both in vitro and in vivo. Nutr. Cancer, 2012, 64(4), 599-606.
[http://dx.doi.org/10.1080/01635581.2012.665564] [PMID: 22482362]
[153]
Lee, I.K.; Yun, B.S. Highly oxygenated and unsaturated metabolites providing a diversity of hispidin class antioxidants in the medicinal mushrooms Inonotus and Phellinus. Bioorg. Med. Chem., 2007, 15(10), 3309-3314.
[http://dx.doi.org/10.1016/j.bmc.2007.03.039] [PMID: 17387019]
[154]
Carneiro, A.A.; Ferreira, I.C.; Dueñas, M.; Barros, L.; da Silva, R.; Gomes, E.; Santos-Buelga, C. Chemical composition and antioxidant activity of dried powder formulations of Agaricus blazei and Lentinus edodes. Food Chem., 2013, 138(4), 2168-2173.
[http://dx.doi.org/10.1016/j.foodchem.2012.12.036] [PMID: 23497872]
[155]
Lemieszek, M.; Rzeski, W. Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class. Contemp. Oncol. (Pozn.), 2012, 16(4), 285-289.
[http://dx.doi.org/10.5114/wo.2012.30055] [PMID: 23788896]
[156]
Yoshida, I.; Kiho, T.; Usui, S.; Sakushima, M.; Ukai, S. Polysaccharides in fungi. XXXVII. Immunomodulating activities of carboxymethylated derivatives of linear (13)-alpha-D-glucans extracted from the fruiting bodies of Agrocybe cylindracea and Amanita muscaria. Biol. Pharm. Bull., 1996, 19(1), 114-121.
[http://dx.doi.org/10.1248/bpb.19.114] [PMID: 8820922]
[157]
Luo, X.; Xu, X.; Yu, M.; Yang, Z.; Zheng, L. Characterisation and immunostimulatory activity of an α-(1→6)-d-glucan from the cultured Armillariella tabescens mycelia. Food Chem., 2008, 111(2), 357-363.
[http://dx.doi.org/10.1016/j.foodchem.2008.03.076] [PMID: 26047435]
[158]
Smiderle, F.R.; Baggio, C.H.; Borato, D.G.; Santana-Filho, A.P.; Sassaki, G.L.; Iacomini, M.; Van Griensven, L.J. Anti-inflammatory properties of the medicinal mushroom Cordyceps militaris might be related to its linear (1→3)-β-D-glucan. PLoS One, 2014, 9(10), e110266.
[http://dx.doi.org/10.1371/journal.pone.0110266] [PMID: 25330371]
[159]
Lee, I.K.; Kim, Y.S.; Jang, Y.W.; Jung, J.Y.; Yun, B.S. New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus. Bioorg. Med. Chem. Lett., 2007, 17(24), 6678-6681.
[http://dx.doi.org/10.1016/j.bmcl.2007.10.072] [PMID: 17980585]
[160]
Gao, Y.; Gao, H.; Chan, E.; Tang, W.; Xu, A.; Yang, H.; Huang, M.; Lan, J.; Li, X.; Duan, W.; Xu, C.; Zhou, S. Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice. Immunol. Invest., 2005, 34(2), 171-198.
[http://dx.doi.org/10.1081/IMM-55813] [PMID: 15921158]
[161]
Kim, S.P.; Nam, S.H.; Friedman, M. Hericium erinaceus (Lion’s Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice. J. Agric. Food Chem., 2013, 61(20), 4898-4904.
[http://dx.doi.org/10.1021/jf400916c] [PMID: 23668749]
[162]
Lo, H.C.; Hsu, T.H.; Lin, F.Y.; Wasser, S.P.; Chen, Y.H.; Lee, C.H. Effects of yellow brain culinary-medicinal mushroom, Tremella mesenterica Ritz.:Fr. (higher Basidiomycetes), on immune function in normal and type 1 diabetic rats. Int. J. Med. Mushrooms, 2012, 14(5), 447-457.
[http://dx.doi.org/10.1615/IntJMedMushr.v14.i5.20] [PMID: 23510213]
[163]
Hapuarachchi, K.K.; Cheng, C.R.; Wen, T.C.; Jeewon, R.; Kakumyan, P. Mycosphere Essays 20: Therapeutic potential of Ganoderma species: Insights into its use as traditional medicine. Mycosphere, 2017, 8(10), 1653-1694.
[http://dx.doi.org/10.5943/mycosphere/8/10/5]
[164]
Chen, J.; Seviour, R. Medicinal importance of fungal beta-(13), (16)-glucans. Mycol. Res., 2007, 111(Pt 6), 635-652.
[http://dx.doi.org/10.1016/j.mycres.2007.02.011] [PMID: 17590323]
[165]
Yalin, W.; Ishurd, O.; Cuirong, S.; Yuanjiang, P. Structure analysis and antitumor activity of (13)-beta-d-glucans (cordyglucans) from the mycelia of Cordyceps sinensis. Planta Med., 2005, 71(4), 381-384.
[http://dx.doi.org/10.1055/s-2005-864111] [PMID: 15856422]
[166]
Lemieszek, M.K.; Nunes, F.M.; Rzeski, W. Branched mannans from the mushroom Cantharellus cibarius enhance the anticancer activity of natural killer cells against human cancers of lung and colon. Food Funct., 2019, 10(9), 5816-5826. a
[http://dx.doi.org/10.1039/C9FO00510B] [PMID: 31463494]
[167]
Lemieszek, M.K.; Marques, P.S.; Ribeiro, M.; Ferreira, D.; Marques, G.; Chaves, R.; Pożarowski, P.; Nunes, F.M.; Rzeski, W. Mushroom small RNAs as potential anticancer agents: A closer look at Cantharellus cibarius proapoptotic and antiproliferative effects in colon cancer cells. Food Funct., 2019, 10(5), 2739-2751. b
[http://dx.doi.org/10.1039/C8FO02378F] [PMID: 31038490]
[168]
Xu, X.; Yan, H.; Tang, J.; Chen, J.; Zhang, X. Polysaccharides in Lentinus edodes: isolation, structure, immunomodulating activity and future prospective. Crit. Rev. Food Sci. Nutr., 2014, 54(4), 474-487.
[http://dx.doi.org/10.1080/10408398.2011.587616] [PMID: 24236998]
[169]
Ng, T.B.; Lam, Y.W.; Wang, H. Calcaelin, a new protein with translation-inhibiting, antiproliferative and antimitogenic activities from the mosaic puffball mushroom Calvatia caelata. Planta Med., 2003, 69(3), 212-217.
[http://dx.doi.org/10.1055/s-2003-38492] [PMID: 12677523]
[170]
Lam, S.K.; Ng, T.B. Hypsin, a novel thermostable ribosome-inactivating protein with antifungal and antiproliferative activities from fruiting bodies of the edible mushroom Hypsizigus marmoreus. Biochem. Biophys. Res. Commun., 2001, 285(4), 1071-1075.
[http://dx.doi.org/10.1006/bbrc.2001.5279] [PMID: 11467862]
[171]
Ng, T.B.; Wong, J.H.; Cheung, R.C.F.; Tse, T.F.; Tam, T.; Chan, H. Mushrooms: proteins, polysaccharidepeptide complexes and polysaccharides with antiproliferative and anticancer activities. Int. J. Cancer Res. Prev., 2014, 7(3/4), 287-300.
[172]
Pohleven, J.; Obermajer, N.; Sabotic, J.; Anzlovar, S.; Sepcić, K.; Kos, J.; Kralj, B.; Strukelj, B.; Brzin, J. Purification, characterization and cloning of a ricin B-like lectin from mushroom Clitocybe nebularis with antiproliferative activity against human leukemic T cells. Biochim. Biophys. Acta, 2009, 1790(3), 173-181.
[http://dx.doi.org/10.1016/j.bbagen.2008.11.006] [PMID: 19100814]
[173]
Zhao, J.K.; Wang, H.X.; Ng, T.B. Purification and characterization of a novel lectin from the toxic wild mushroom Inocybe umbrinella. Toxicon, 2009, 53(3), 360-366.
[http://dx.doi.org/10.1016/j.toxicon.2008.12.009] [PMID: 19111567]
[174]
Zhang, G.; Sun, J.; Wang, H.; Ng, T.B. First isolation and characterization of a novel lectin with potent antitumor activity from a Russula mushroom. Phytomedicine, 2010, 17(10), 775-781.
[http://dx.doi.org/10.1016/j.phymed.2010.02.001] [PMID: 20378319]
[175]
Wang, P.H.; Hsu, C.I.; Tang, S.C.; Huang, Y.L.; Lin, J.Y.; Ko, J.L. Fungal immunomodulatory protein from Flammulina velutipes induces interferon-γ production through p38 mitogen-activated protein kinase signaling pathway. J. Agric. Food Chem., 2004, 52(9), 2721-2725.
[http://dx.doi.org/10.1021/jf034556s] [PMID: 15113182]
[176]
Pushparajah, V.; Fatima, A.; Chong, C.H.; Gambule, T.Z.; Chan, C.J.; Ng, S.T.; Tan, C.S.; Fung, S.Y.; Lee, S.S.; Tan, N.H.; Lim, R.L. Characterisation of a new fungal immunomodulatory protein from tiger milk mushroom, Lignosus rhinocerotis. Sci. Rep., 2016, 6(1), 30010.
[http://dx.doi.org/10.1038/srep30010] [PMID: 27460640]
[177]
Panthong, S.; Boonsathorn, N.; Chuchawankul, S. Antioxidant activity, anti-proliferative activity, and amino acid profiles of ethanolic extracts of edible mushrooms. Genet. Mol. Res., 2016, 15(4), 1-14.
[http://dx.doi.org/10.4238/gmr15048886] [PMID: 27813595]
[178]
Sumkhemthong, S.; Suksomtip, M.; Chanvorachote, P.; Chaotham, C. Anticancer activity of peptide extracted from edible mushroom; Lentinus squarrosulus in human lung cancer cells. Planta Med., 2016, 82, sS1-S38.
[http://dx.doi.org/10.1055/s-0036-1596829]
[179]
Grob, C.S.; Danforth, A.L.; Chopra, G.S.; Hagerty, M.; McKay, C.R.; Halberstadt, A.L.; Greer, G.R. Pilot study of psilocybin treatment for anxiety in patients with advanced-stage cancer. Arch. Gen. Psychiatry, 2011, 68(1), 71-78.
[http://dx.doi.org/10.1001/archgenpsychiatry.2010.116] [PMID: 20819978]
[180]
Zhao, Y.Y.; Chao, X.; Zhang, Y.; Lin, R.C.; Sun, W.J. Cytotoxic steroids from Polyporus umbellatus. Planta Med., 2010, 76(15), 1755-1758.
[http://dx.doi.org/10.1055/s-0030-1249926] [PMID: 20458671]
[181]
Martínez-Montemayor, M.M.; Ling, T.; Suárez-Arroyo, I.J.; Ortiz-Soto, G.; Santiago-Negrón, C.L.; Lacourt-Ventura, M.Y.; Valentín-Acevedo, A.; Lang, W.H.; Rivas, F. Identification of biologically active ganoderma lucidum compounds and synthesis of improved derivatives that confer anti-cancer activities in vitro. Front. Pharmacol., 2019, 10, 115.
[http://dx.doi.org/10.3389/fphar.2019.00115] [PMID: 30837881]
[182]
Won, S.Y.; Park, E.H. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. J. Ethnopharmacol., 2005, 96(3), 555-561.
[http://dx.doi.org/10.1016/j.jep.2004.10.009] [PMID: 15619578]
[183]
Nakamura, K.; Shinozuka, K.; Yoshikawa, N. Anticancer and antimetastatic effects of cordycepin, an active component of Cordyceps sinensis. J. Pharmacol. Sci., 2015, 127(1), 53-56.
[http://dx.doi.org/10.1016/j.jphs.2014.09.001] [PMID: 25704018]
[184]
Zhang, Y.; Mills, G.L.; Nair, M.G. Cyclooxygenase inhibitory and antioxidant compounds from the mycelia of the edible mushroom Grifola frondosa. J. Agric. Food Chem., 2002, 50(26), 7581-7585.
[http://dx.doi.org/10.1021/jf0257648] [PMID: 12475274]
[185]
Paterson, R.R.M. Ganoderma - a therapeutic fungal biofactory. Phytochemistry, 2006, 67(18), 1985-2001.
[http://dx.doi.org/10.1016/j.phytochem.2006.07.004] [PMID: 16905165]
[186]
Bok, J.W.; Lermer, L.; Chilton, J.; Klingeman, H.G.; Towers, G.H. Antitumor sterols from the mycelia of Cordyceps sinensis. Phytochemistry, 1999, 51(7), 891-898.
[http://dx.doi.org/10.1016/S0031-9422(99)00128-4] [PMID: 10423860]
[187]
Lee, I.K.; Jung, J.Y.; Seok, S.J.; Kim, W.G.; Yun, B.S. Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis. Bioorg. Med. Chem. Lett., 2006, 16(21), 5621-5624.
[http://dx.doi.org/10.1016/j.bmcl.2006.08.016] [PMID: 16908141]
[188]
Mo, S.; Wang, S.; Zhou, G.; Yang, Y.; Li, Y.; Chen, X.; Shi, J. Phelligridins C-F: cytotoxic pyrano[4,3-c][2]benzopyran-1,6-dione and furo[3,2-c]pyran-4-one derivatives from the fungus Phellinus igniarius. J. Nat. Prod., 2004, 67(5), 823-828.
[http://dx.doi.org/10.1021/np030505d] [PMID: 15165144]
[189]
Dubost, N.J.; Beelman, R.B.; Peterson, D.; Royse, D.J. Identification and quantification of ergothioneine in cultivated mushrooms by liquid chromatography-mass spectroscopy. Int. J. Med. Mushrooms, 2006, 8(3), 215-222.
[http://dx.doi.org/10.1615/IntJMedMushr.v8.i3.30]
[190]
Figueiredo, L.; Régis, W.C.B. Medicinal mushrooms in adjuvant cancer therapies: An approach to anticancer effects and presumed mechanisms of action. Nutrire, 2017, 42(1), 28.
[http://dx.doi.org/10.1186/s41110-017-0050-1]
[191]
Lee, M.S.; Hwang, B.S.; Lee, I.K.; Seo, G.S.; Yun, B.S. Chemical constituents of the culture broth of Phellinus linteus and their antioxidant activity. Mycobiology, 2015, 43(1), 43-48.
[http://dx.doi.org/10.5941/MYCO.2015.43.1.43] [PMID: 25892914]
[192]
Liu, J.H.; Li, L.; Shang, X.D.; Zhang, J.L.; Tan, Q. Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus. J. Ethnopharmacol., 2016, 183, 54-58.
[http://dx.doi.org/10.1016/j.jep.2015.09.004] [PMID: 26364939]
[193]
Jiang, Z.; Kempinski, C.; Chappell, J. extraction and analysis of terpenes/terpenoids. Curr. Protoc. Plant Biol., 2016, 1(2), 345-358.
[http://dx.doi.org/10.1002/cppb.20024] [PMID: 27868090]
[194]
Kao, C.; Jesuthasan, A.C.; Bishop, K.S.; Glucina, M.P.; Ferguson, L.R. Anticancer activities of Ganoderma lucidum: Active ingredients and pathways. Funct. Food Health Dis., 2013, 3(2), 48-65.
[http://dx.doi.org/10.31989/ffhd.v3i2.65]
[195]
Wang, C.; Youle, R.J. The role of mitochondria in apoptosis. Annu. Rev. Genet., 2009, 43, 95-118.
[http://dx.doi.org/10.1146/annurev-genet-102108-134850] [PMID: 19659442]
[196]
Zaidman, B.Z.; Yassin, M.; Mahajna, J.; Wasser, S.P. Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl. Microbiol. Biotechnol., 2005, 67(4), 453-468.
[http://dx.doi.org/10.1007/s00253-004-1787-z] [PMID: 15726350]
[197]
Wang, C.Y.; Bai, X.Y.; Wang, C.H. Traditional Chinese medicine: A treasured natural resource of anticancer drug research and development. Am. J. Chin. Med., 2014, 42(3), 543-559.
[http://dx.doi.org/10.1142/S0192415X14500359] [PMID: 24871650]
[198]
Ferreira, I.C.; Vaz, J.A.; Vasconcelos, M.H.; Martins, A. Compounds from wild mushrooms with antitumor potential. Anticancer. Agents Med. Chem., 2010, 10(5), 424-436.
[http://dx.doi.org/10.2174/1871520611009050424] [PMID: 20545620]
[199]
Endo, M.; Beppu, H.; Akiyama, H.; Wakamatsu, K.; Ito, S.; Kawamoto, Y.; Shimpo, K.; Sumiya, T.; Koike, T.; Matsui, T. Agaritine purified from Agaricus blazei Murrill exerts anti-tumor activity against leukemic cells. Biochim. Biophys. Acta, 2010, 1800(7), 669-673.
[http://dx.doi.org/10.1016/j.bbagen.2010.03.016] [PMID: 20347942]
[200]
Yuan, H.; Ma, Q.; Ye, L.; Piao, G. The traditional medicine and modern medicine from natural products. Molecules, 2016, 21(5), 559.
[http://dx.doi.org/10.3390/molecules21050559] [PMID: 27136524]
[201]
Chihara, G.; Hamuro, J.; Maeda, Y.; Arai, Y.; Fukuoka, F. Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) Sing. (an edible mushroom). Cancer Res., 1970, 30(11), 2776-2781.
[PMID: 5530561]
[202]
Ochiai, T.; Isono, K.; Suzuki, T.; Koide, Y.; Gunji, Y.; Nagata, M. Effect of immunotherapy with lentinan on patients’ survival and immunological parameters in patients with advanced gastric cancer: results of a multi‐centre randomized controlled study. Int. J. Immunother., 1992, 8(3), 161-169.
[203]
Fujimoto, S.; Furue, H.; Kimura, T.; Kondo, T.; Orita, K.; Taguchi, T.; Yoshida, K.; Ogawa, N. Clinical outcome of postoperative adjuvant immunochemotherapy with sizofiran for patients with resectable gastric cancer: A randomised controlled study. Eur. J. Cancer, 1991, 27(9), 1114-1118.
[http://dx.doi.org/10.1016/0277-5379(91)90306-X] [PMID: 1835619]
[204]
Torkelson, C.J.; Sweet, E.; Martzen, M.R.; Sasagawa, M.; Wenner, C.A.; Gay, J.; Putiri, A.; Standish, L.J. Phase 1 clinical trial of Trametes versicolor in women with breast cancer. ISRN Oncol., 2012, 2012251632.
[http://dx.doi.org/10.5402/2012/251632] [PMID: 22701186]
[205]
Kobayashi, H.; Matsunaga, K.; Fujii, M. PSK as a chemopreventive agent. Cancer Epidemiol. Biomarkers Prev., 1993, 2(3), 271-276.
[PMID: 8318880]
[206]
Paul, M.; Kumar Panda, M.; Thatoi, H. Developing Hispolon-based novel anticancer therapeutics against human (NF-κβ) using in silico approach of modelling, docking and protein dynamics. J. Biomol. Struct. Dyn., 2019, 37(15), 3947-3967.
[http://dx.doi.org/10.1080/07391102.2018.1532321] [PMID: 30295165]
[207]
Meenambiga, S.S.; Rajagopal, K.; Durga, R. In silico docking studies on the components of Inonotus sp., a medicinal mushroom against cyclooxygenase-2 enzyme. Asian J. Pharm. Clin. Res., 2015, 8(3), 142-145.
[208]
Gupte, A.; Palande, A.; Venkata, S.; Pol, R. Docking studies of Ganoderma lucidum. Int. J. Pharm. Sci. Res., 2018, 9(3), 1100-1105.
[209]
Aguirre, R.; Cutiño, L.; Peña, J.; Morris, H.; Beltran, Y.; Llauradó, G.; Reyes, Y.; Meneses, M.; Perraud-Gaime, I. An in silico approach for evaluating the antitumor and epigenetic modulating potential of phenolic compounds occurring in edible and medicinal mushrooms. Int. J. Phytocosmet. Nat. Ingred., 2018, 5(1), 6.
[http://dx.doi.org/10.15171/ijpni.2018.06]
[210]
Fernando, M.D.M.; Adhikari, A.; Senathilake, N.H.K.S.; de Silva, E.D.; Nanayakkara, C.M.; Wijesundera, R.L.C.; Soysa, P.; Silva, B. In silico pharmacological analysis of a potent anti-hepatoma compound of mushroom origin and emerging role as an adjuvant drug lead. Food Nutr. Sci., 2019, 10(11), 1313-1333.
[http://dx.doi.org/10.4236/fns.2019.1011095]
[211]
D, R.R.; Kandagalla, S.; M, K. Exploring the ethnomycological potential of Lentinus squarrosulus Mont. through GC-MS and chemoinformatics tools. Mycology, 2019, 11(1), 78-89.
[http://dx.doi.org/10.1080/21501203.2019.1707724] [PMID: 32128284]
[212]
Maruca, A.; Moraca, F.; Rocca, R.; Molisani, F.; Alcaro, F.; Gidaro, M.C.; Alcaro, S.; Costa, G.; Ortuso, F. Chemoinformatic database building and in silico hit-identification of potential multi-targeting bioactive compounds extracted from mushroom species. Molecules, 2017, 22(9), 1571.
[http://dx.doi.org/10.3390/molecules22091571]
[213]
Arvas, M.; Kivioja, T.; Mitchell, A.; Saloheimo, M.; Ussery, D.; Penttila, M.; Oliver, S. Comparison of protein coding gene contents of the fungal phyla Pezizomycotina and Saccharomycotina. BMC Genomics, 2007, 8(1), 325.
[http://dx.doi.org/10.1186/1471-2164-8-325] [PMID: 17868481]
[214]
Ismaya, W.T. Yunita; Damayanti, S.; Wijaya, C.; Tjandrawinata, R.R.; Retnoningrum, D.S.; Rachmawati, H. In silico study to develop a lectin-like protein from mushroom Agaricus bisporus for pharmaceutical application. Sci. Pharm., 2016, 84(1), 203-217.
[http://dx.doi.org/10.3797/scipharm.ISP.2015.11] [PMID: 27110510]

Rights & Permissions Print Cite
Article Metrics
23
1
© 2024 Bentham Science Publishers | Privacy Policy