摘要
内吞起源的细胞外囊泡(EVs)被称为外来体。 这些囊泡由细胞释放,存在于生物流体中,例如唾液,尿液和血浆。 这些囊泡由小RNA,DNA,蛋白质组成,在许多生理过程中起着至关重要的作用。 在中枢神经系统(CNS)中,它们参与各种生理过程,例如神经细胞的应激,细胞之间的通讯,突触可塑性和神经发生。 外泌体在抑郁症中的作用有待进一步探讨。 已知外泌体可以穿过由神经胶质细胞星形胶质细胞组成的血脑屏障(BBB)。 这些囊泡的优势之一是它们能够将大分子(如DNA,蛋白质,mRNA和miRNA)转移至受体细胞。 这篇综述集中在外泌体在抑郁症中的潜在作用及其作为抑郁症的治疗选择或诊断工具的利用。
关键词: 抑郁症,外来体,血脑屏障,血清素,生物标志物,氧化应激。
图形摘要
Current Drug Targets
Title:Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression
Volume: 22 Issue: 2
关键词: 抑郁症,外来体,血脑屏障,血清素,生物标志物,氧化应激。
摘要: Extracellular vesicles (EVs) of endocytic origin are known as exosomes. These vesicles are released by cells and are found in biofluids, such as saliva, urine, and plasma. These vesicles are made up of small RNA, DNA, proteins, and play a vital role in many physiological processes. In the central nervous system (CNS), they participate in various physiological processes such as stress of nerve cells, communication between the cells, synaptic plasticity, and neurogenesis. The role of exosomes in depression needs to be explored further. It is known that exosomes can cross the blood brain barrier (BBB), which is made up of glial cells astrocytes. One of the advantages of these vesicles is that they are able to transfer macromolecules like DNA, protein, mRNAs, and miRNAs to recipient cells. This review focuses on the potential role of exosomes in depression and their utilization as a treatment option or diagnostic tool of depression.
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Cite this article as:
Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression, Current Drug Targets 2021; 22 (2) . https://dx.doi.org/10.2174/1389450121999201006193005
DOI https://dx.doi.org/10.2174/1389450121999201006193005 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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