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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

CYP1A1 / 1B1和相关化学预防剂对致癌物的激活作用

卷 21, 期 1, 2021

发表于: 06 October, 2020

页: [21 - 54] 页: 34

弟呕挨: 10.2174/1568009620666201006143419

价格: $65

摘要

CYP1A1和CYP1B1是肝外P450家族成员，参与诸如PAHs，杂环胺和含卤素的有机化合物等致癌物的代谢。 CYP1A1 / 1B1也参与内源性17-β-雌二醇的代谢，产生雌二醇氢醌，这是致癌性半醌和醌的中间体。 CYP1A1和CYP1B1蛋白共享大约一半的氨基酸序列同一性，但晶体结构不同。结果，CYP1A1和CYP1B1对化学致癌物具有不同的底物特异性。这篇综述将介绍CYP1A1 / 1B1的一般分子生物学知识以及由这两种酶调节的致癌物的代谢过程。在过去的四十年中，与CYP1A1 / 1B1相互作用的多种天然产物和合成化合物已被确认为有效的化学预防剂。这些化合物根据其独特的机理主要分为间接或直接CYP1A1 / 1B1抑制剂。间接CYP1A1 / 1B1抑制剂通常会阻碍CYP1A1 / 1B1基因的转录和翻译，或干扰芳基烃受体（AHR）从胞质域向细胞核的移位。另一方面，直接抑制剂抑制CYP1A1 / 1B1的催化活性。根据结构特征，间接抑制剂可分为以下几类：类黄酮，生物碱和合成芳香族化合物，而直接抑制剂可分为类黄酮，香豆素，丁二烯，含硫异硫氰酸酯和合成芳香族化合物。这篇综述将总结这些化学预防剂的体外和体内活性，它们的工作机制以及相关的SAR。这将提供对CYP1介导的致癌作用的分子机制的更好理解，并将在不久的将来对发现新型化学预防剂产生重大影响。

关键词: CYP1A1，CYP1B1，致癌物，AHR，癌症，化学预防剂，天然产物，构效关系。

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图形摘要

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