Therapeutic Potential of Non-Coding RNAs and TLR Signalling Pathways in Rheumatoid Arthritis

Title:Therapeutic Potential of Non-Coding RNAs and TLR Signalling Pathways in Rheumatoid Arthritis

Volume: 22 Issue: 11

Author(s): Jingjing Liu, Xiaoxu Wang, Shufeng Wang*Fengxia Liu*

Affiliation:

• Medical Experimental Training Center, Weifang Medical University, Weifang 261000, Shandong Province,China

• Department of Allergy of the First Affiliated Hospital, Weifang Medical University, Weifang 261000, Shandong Province,China

Keywords: Non-coding RNA, toll-like receptor, NF-κB, rheumatoid arthritis, signaling pathway, pathogenesis.

Abstract:

Background: Rheumatoid Arthritis (RA) is a common connective tissue disease, characteristic of chronic and invasive synovitis in single or multiple joints and vasculitis. RA is a heterogeneous disease with unclear pathogenesis. Therefore, exploring the etiology and pathogenesis of the disease is essential for identifying new promising treatment strategies for RA. Accumulated data have implicated the significant role of non-coding RNA in RA, some of which are demonstrated to regulate inflammation and autoimmunity in RA through the Toll-Like Receptor (TLR) signaling pathway. To clarify the mechanism of non-coding RNA regulating the generation of proinflammatory mediators is helpful for understanding the pathogenesis of RA. Moreover, these well established non-coding RNAs can serve as novel biotargets for RA diagnosis and treatment.

Conclusion: Here, we summarize currently available data on non-coding RNAs, TLRs, and the underlying molecular mechanisms in RA. This review will provide insight into the potential use of noncoding RNA as disease diagnosis and treatment markers for RA.

Cite this article as:

Liu Jingjing , Wang Xiaoxu , Wang Shufeng *, Liu Fengxia*, Therapeutic Potential of Non-Coding RNAs and TLR Signalling Pathways in Rheumatoid Arthritis, Current Pharmaceutical Biotechnology 2021; 22 (11) . https://dx.doi.org/10.2174/1389201021666201001142829