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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Mini-Review Article

Recent Update on the Anti-infective Potential of β-carboline Analogs

Author(s): Faheem, Banoth Karan Kumar, Kondapalli Venkata Gowri Chandra Sekhar, Selvaraj Kunjiappan, Joazaizulfazli Jamalis, Rafael Balaña-Fouce and Murugesan Sankaranarayanan*

Volume 21, Issue 4, 2021

Published on: 01 October, 2020

Page: [398 - 425] Pages: 28

DOI: 10.2174/1389557520666201001130114

Price: $65

Abstract

β-Carboline, a naturally occurring indole alkaloid, holds a momentous spot in the field of medicinal chemistry due to its myriad of pharmacological actions like anticancer, antiviral, antibacterial, antifungal, antileishmanial, antimalarial, neuropharmacological, anti-inflammatory and antithrombotic among others. β-Carbolines exhibit their pharmacological activity via diverse mechanisms. This review provides a recent update (2015-2020) on the anti-infective potential of natural and synthetic β-carboline analogs focusing on its antibacterial, antifungal, antiviral, antimalarial, antileishmanial and antitrypanosomal properties. In cases where enough details are available, a note on its mechanism of action is also added.

Keywords: β-Carboline, PYRIDO indole, antibacterial, antifungal, antiviral, antiprotozoal.

Graphical Abstract


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