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当代肿瘤药物靶点

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ISSN (Online): 1873-5576

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Research Article

WDFY3新抗原作为肝外胆管癌长期存活者预后标志物的鉴定

卷 20, 期 11, 2020

页: [875 - 886] 页: 12

弟呕挨: 10.2174/1568009620999200918121456

价格: $65

摘要

WDFY3新抗原作为肝外胆管癌长期存活者预后标志物的鉴定 背景：新抗原是新形成的抗原，以前未被免疫系统识别。它们可能是由于突变而形成的肿瘤蛋白质改变而引起的。尽管新抗原最近已与癌症的长期幸存者（例如黑色素瘤和结肠直肠癌）的抗肿瘤免疫力相关联，但它们在许多癌症类型中的预后和免疫调节作用仍然不确定。 目的：本研究的目的是确定肝外胆管癌（EHCC）长期存活的预后指标。 方法：我们结合全外显子组测序（WES），RNA测序（RNA-seq），计算生物物理学和免疫组织化学研究了EHCC的新抗原，EHCC是一种罕见的侵袭性癌症，其5年总生存率低于10％。 结果：我们的分析显示，IC50 <500 nM时，高质量新抗原负荷的中性粒细胞浸润相关趋势有所降低（r = -0.445，P = 0.043）。在检查的24例EHCC患者中，我们在短期存活者中确定了4名具有WDFY3新抗原的长期存活者，而没有一名携带WDFY3新抗原的长期存活者。 WDFY3新抗原与中性粒细胞浸润（p = 0.013）降低，CCL5（p = 0.025），CXCL9（p = 0.036）和TIGIT（p = 0.016）的表达降低以及预后不良（p = 0.030）相关。 。相反，预后与肿瘤突变负担，新抗原负荷或免疫细胞浸润没有显着相关。 结论：我们建议WDFY3新抗原可能通过调节抗肿瘤免疫力来影响预后，并且WDFY3新抗原可能被用作EHCC免疫治疗的潜在靶标。

关键词: 肝外胆管癌，WDFY3新抗原，预后，免疫细胞浸润，免疫特征基因，肿瘤突变负担。

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