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Current Organic Chemistry

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ISSN (Online): 1875-5348

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Review Article

Microwave-assisted Amination Reactions: An Overview

Author(s): Sankaran Radhika, Mohan Neetha, Thaipparambil Aneeja and Gopinathan Anilkumar*

Volume 24, Issue 19, 2020

Page: [2235 - 2255] Pages: 21

DOI: 10.2174/1385272824999200914111246

Price: $65

Abstract

C-N coupling reactions were found to be attractive among researchers owing to the importance of C-N bond formation in heterocyclic synthesis. Hence C-N bond formation via amination reaction with the assistance of microwave radiations gained significant attraction recently. Microwave-assisted reactions are greener, faster and generally efficient compared to the conventional thermal reactions offering better purity of the product with enhancement in the yield. It was surprisingly revealed that several new advancements in amination reactions were highly influenced by this greener technology. This first review on microwave-assisted amination reaction focuses on the novel amination strategies that emerged with the help of microwave methodology, and covers literature up to 2019.

Keywords: Microwave-assisted reaction, amination, C-N bond, substitution, amines, catalyst, green chemistry.

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