摘要
早产儿卵巢功能衰竭(POF)是指40岁以下妇女的卵巢功能障碍。其特点是低雌激素水平、促性腺激素水平高、闭经、不孕症,严重影响妇女的身心健康。POF的致病因素包括医源性因素、自身免疫性因素、遗传因素、氧化应激、感染、甲状腺功能障碍和肾上腺疾病。化疗是引起POF的常见原因,目前正受到越来越多的关注。随着现代医学的发展和对癌症认识的进步,妇女的癌症生存率显著提高。目前,POF的主要治疗方案是激素补充和体外激活(IVA),但仍没有针对POF的特异性治疗方法。干细胞,被称为多细胞生物的未分化细胞,表现出自我更新、定向分化为不同细胞和免疫原性低的特征。因此,它们在再生医学中具有潜力,并为POF的治疗提供了一个有前途的方向。本文综述了化疗诱导的POF模型中各种干细胞的最新研究进展,为进一步的研究和治疗提供了理论依据。
关键词: 卵巢衰竭、化疗、卵巢癌、颗粒细胞、干细胞、间充质干细胞。
Current Molecular Medicine
Title:The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure
Volume: 21 Issue: 5
关键词: 卵巢衰竭、化疗、卵巢癌、颗粒细胞、干细胞、间充质干细胞。
摘要: Premature ovarian failure (POF) refers to ovarian dysfunction in women under 40 years old. It is characterized by low estrogen, high gonadotropin, amenorrhea, and infertility, which seriously affect physical and mental health of women. The pathogenic factors of POF include iatrogenic factors, autoimmune factors, genetic factors, oxidative stress, infection, thyroid dysfunction, and adrenal diseases. Chemotherapy is a common cause of POF and is gaining increasing attention. With the development of modern medicine and advances in understanding cancer, women’s cancer survival rates have been significantly increased. Currently, the main treatment options for POF are hormone supplement and in vitro activation (IVA), but there is still no specific treatment for POF. Stem cells, known as undifferentiated cells of multicellular organisms, exhibit characteristics of self-renewal, directional differentiation into different cells, and low immunogenicity. Thus, they have potential in regenerative medicine and provide a promising direction for POF treatment. In this review, we summarize the latest research progress of various stem cells in chemotherapy-induced POF models to provide a theoretical basis for further research and treatment.
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The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure, Current Molecular Medicine 2021; 21 (5) . https://dx.doi.org/10.2174/1566524020666200905113907
DOI https://dx.doi.org/10.2174/1566524020666200905113907 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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