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Review Article

重新利用西洛他唑治疗雷诺现象

卷 28, 期 12, 2021

发表于: 03 September, 2020

页: [2409 - 2417] 页: 9

弟呕挨: 10.2174/0929867327666200903114154

价格: $65

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摘要

雷诺现象(RP)的结果夸大的寒冷诱导血管收缩。RP患者血管痉挛发作，手指血流灌注不足，导致手指水平三色变化。严重的RP可能导致溃疡并威胁组织的生存能力。许多药物已被用于缓解RP的症状。这些药物包括钙通道阻滞剂、cGMP特异性磷酸二酯酶5型抑制剂、前列环素类似物和血管紧张素受体阻滞剂。尽管这些药物种类繁多，但它们不能治疗RP，而只能减轻其症状。到目前为止，美国食品和药物管理局还没有批准治疗RP的药物。西洛他唑是磷酸二酯酶iii的选择性抑制剂，最初用于治疗间歇性跛行。由于它的抗血小板和血管扩张特性，西洛他唑正被重新用作一种潜在的RP药物。本文就西洛他唑增强RP患者血液灌注的不同作用线作一综述。

关键词: 心血管疾病，西洛他唑，手指缺血，药物再利用，雷诺氏现象，冷诱导的血管收缩

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