2 型糖尿病的先天免疫改变：了解感染易感性

Title:Innate Immunity Alterations in Type 2 Diabetes Mellitus: Understanding Infection Susceptibility

Volume: 21 Issue: 4

关键词: 先天反应、吞噬作用、2 型糖尿病、感染、抗菌肽、先天免疫细胞。

摘要: Diabetes is a chronic disease characterized by marked alterations in the metabolism of glucose and by high concentrations of glucose in the blood due to a decreased insulin production or resistance to the action of this hormone in peripheral tissues. The International Diabetes Federation estimates a global incidence of diabetes of about 10% in the adult population (20 - 79 years old), some 430 million cases reported worldwide in 2018. It is well documented that people with diabetes have a higher susceptibility to infectious diseases and therefore show higher morbidity and mortality compared to the non-diabetic population. Given that the innate immune response plays a fundamental role in protecting against invading pathogens through a myriad of humoral and cellular mechanisms, the present work makes a comprehensive review of the innate immune alterations in patients with type 2 diabetes mellitus (T2D) as well as a brief description of the molecular events leading or associated to such conditions. We show that in these patients a compromised innate immune response increases susceptibility to infections.

Cite this article as:

Innate Immunity Alterations in Type 2 Diabetes Mellitus: Understanding Infection Susceptibility, Current Molecular Medicine 2021; 21 (4) . https://dx.doi.org/10.2174/1566524020999200831124534