Central Regulatory Role of Cytokines in Periodontitis and Targeting Options

doi:10.2174/0929867327666200824112732
摘要

背景：牙周炎是一种免疫炎症性疾病，可导致牙周区域的骨骼和结缔组织进行性破坏。细胞因子网络在组织稳态、免疫细胞募集以控制致病影响和破骨细胞功能的调节中起主要作用，从而调节免疫反应的强度和持续时间。本综述提供了与牙周炎发病机制和进展有关的主要细胞因子及其靶向潜力的更新，以丰富当前的治疗选择。方法：对文献数据库（PubMed、MEDLINE、Scopus）进行结构化搜索，以进行同行评审的细胞因子研究，重点是过去十年的牙周炎。在筛选的论文中进行了定性内容分析，并提供了对主要发现的批判性讨论。结果：在牙周炎患者中检测到细胞因子谱的改变，促炎和/或抗炎细胞因子的相互作用与疾病发病机制有关。在最突出的促炎细胞因子中，TNF-α、IL-1β、IL-17、IL-6 和趋化因子 CXCL-6、CXCL-8 在牙周炎患者中过度表达并与疾病进展相关。另一方面，抗炎性 IL-4 和 IL-11 水平降低，而 IL-12 和 IFN-γ 表达在牙周病中起双重作用。目前的牙周炎治疗策略包括选择性抗生素、抗菌光动力疗法和益生菌，它们可以调节细胞因子网络，并且当与特定的抗细胞因子药物联合应用时，可以发挥额外的有益作用。结论：很明显，细胞因子在牙周炎骨破坏的炎症过程和免疫细胞反应中起着重要的调节作用。应将特定的细胞因子靶向作为当前牙周治疗的补充治疗方案。
关键词: 牙周炎、炎症、细胞因子、促炎、抗炎、治疗。
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DOI https://dx.doi.org/10.2174/0929867327666200824112732	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
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