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Review Article

癌症免疫学与CAR-T细胞治疗结直肠癌的临床观察

卷 21, 期 3, 2021

发表于: 24 August, 2020

页: [221 - 236] 页: 16

弟呕挨: 10.2174/1566524020666200824103749

价格: $65

摘要

癌症免疫疗法致力于利用免疫系统的微弱强度和特异性来治疗包括结肠直肠癌在内的各种恶性肿瘤。癌症免疫疗法的最新挑战是实践和开发分子免疫学工具，以创建能够有效，安全地增强抗肿瘤反应的策略。经过几次欺骗性的尝试之后，浪潮终于改变了，免疫疗法已成为多种癌症的临床确认治疗方法。免疫治疗方法包括施用抗体或修饰的蛋白，这些抗体或修饰的蛋白通过免疫控制途径阻断细胞活性或共同刺激细胞，癌症疫苗，溶瘤细菌，离体激活的T细胞和自然杀伤细胞的过继转移。经过工程改造的T细胞可用于产生嵌合抗原受体（CAR），以治疗不同的恶性肿瘤，包括近十年来的结直肠癌。尽管在临床上取得了相当大的早期成功，但CAR-T疗法仍会产生一些副作用，有时效果很小。它特别强调了采用CAR-T技术的最新临床证据以及具有良好性能的其他相关免疫治疗方法，并着重指出了该疗法如何影响治疗结局和下一轮高潮，这是结直肠癌的重要临床方面。在这篇综述中，我们概括了为改善CAR-T疗法在结肠癌中的疗效和特异性而产生的最新进展。

关键词: 癌症免疫疗法，大肠癌，CAR-T技术，联合疗法，赘生性细胞，转化，肿瘤细胞。

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