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Review Article

癌症细胞能量代谢的复杂谜题的碎片:靶向癌症治疗的能量代谢和替代疗法的概述

卷 28, 期 18, 2021

发表于: 19 August, 2020

页: [3514 - 3534] 页: 21

弟呕挨: 10.2174/0929867327999200819123357

价格: $65

摘要

在过去的几十年里，癌细胞生物学的几项进展导致了一种被称为“瓦伯格效应”的现象的相关细节。目前，人们普遍认为Warburg效应并不适用于所有癌细胞，因此，随着大量细胞呈现线粒体功能，有氧糖酵解过程面临挑战。为了满足癌细胞快速增殖的需要，癌细胞的能量代谢主要集中在生物能量和生物合成途径上。癌症细胞中碳水化合物、氨基酸和脂类代谢的变化已被报道，这可能在癌症进展中发挥重要作用。据我们所知，这些变化主要归因于基因重组，这导致健康细胞转变为癌细胞。事实上，一些与细胞能量高度相关的酶是致癌基因(如PI3K、HIF1和Myc)和肿瘤抑制蛋白(如p53)的靶标。由于对癌细胞代谢的广泛研究，出现了一些新的治疗策略，除了影响癌细胞的基因重编程外，还旨在中断异常代谢。在这篇综述中，我们概述了癌细胞代谢(碳水化合物，氨基酸和脂类)，并描述了直接影响代谢的致癌基因和肿瘤抑制因子。我们还讨论了一些潜在的治疗候选者，这些候选者已经被设计为靶向和破坏与癌细胞代谢和增殖相关的主要驱动力。

关键词: 碳水化合物代谢、脂类代谢、氨基酸代谢、致癌基因与抑癌基因、靶向治疗、替代治疗

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