摘要
人体微生物群和免疫系统紧密相连。 几项研究表明,正常的皮肤和/或肠道花卉改变可能对疾病的发病机制产生负面影响。 事实上,发现皮肤和肠道微生物群的改变与自身免疫性疾病之间存在很强的关联。 此外,在几种情况下,微生物组和 miRNA 表达之间存在显着的相互作用。 这篇综述文章的目的是阐明一些最常见的皮肤病,如银屑病、特应性皮炎、过敏性接触性皮炎,特别关注表观遗传发病机制,如 miRNA 表达以及皮肤和肠道微生物组的改变。 事实上,关于这两个因素及其可能的相互作用仍然缺乏证据。 我们相信它们的影响可能对筛查、早期诊断和治疗策略至关重要; 因此,该领域可能是进一步研究的一个有希望的挑战。
关键词: 微生物组、皮肤、肠道菌群、自身免疫性疾病、miRNA、真菌。
Current Molecular Medicine
Title:The Role of Skin and Gut Microbiome and Epigenetic Modifications in Skin-Autoimmune Disorders
Volume: 21 Issue: 4
关键词: 微生物组、皮肤、肠道菌群、自身免疫性疾病、miRNA、真菌。
摘要: Human microbiota and immune system are strictly connected to each other. Several studies demonstrated that normal skin and/or gut floral alterations may have negative consequences on disease pathogenesis. Indeed, a strong association between skin and gut microbiota alterations and autoimmune diseases was found. Moreover, a significant interplay between microbiome and miRNAs expression was noticed among several conditions. The aim of this review article is to shed new light on some of the commonest skin disorders such as psoriasis, atopic dermatitis, allergic contact dermatitis, with special regard to epigenetic pathogenetic mechanisms such as miRNAs expression and skin and gut microbiome alterations. Indeed, evidence is still lacking regarding these two factors and their possible interactions. We believe their implications may be crucial for screening, early diagnosis and also therapeutic strategies; therefore, this field could represent a promising challenge for further studies.
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Cite this article as:
The Role of Skin and Gut Microbiome and Epigenetic Modifications in Skin-Autoimmune Disorders, Current Molecular Medicine 2021; 21 (4) . https://dx.doi.org/10.2174/1566524020666200812222324
DOI https://dx.doi.org/10.2174/1566524020666200812222324 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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