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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

脑磁共振成像的顶叶萎缩评分是可靠的视觉量表

卷 17, 期 6, 2020

页: [534 - 539] 页: 6

弟呕挨: 10.2174/1567205017666200807193957

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摘要

目的：该研究的目的是评估我们新的视觉量表的可靠性，以在不同专业人员的脑磁共振成像（MRI）上快速评估顶叶的萎缩。良好的协议将证明其可用于在临床环境中鉴别诊断神经退行性痴呆，特别是早发的阿尔茨海默氏病（AD）。 方法：视觉量表称为顶叶萎缩评分（PAS）是基于T1上三个顶叶结构（后扣带，前突，顶突，顶回）的从0（无萎缩）到2（突出性萎缩）的半定量评估。整个顶叶的MRI加权冠状切片。我们使用kappa统计数据评估了使用PAS独立评分顶壁萎缩的四个评估者之间的评估者内部和评估者之间的一致性。评分者1是神经解剖学家（JM），评分者2是MRI采集和分析专家（II），评分者3是医学生（OP），评分者4是神经科医生（DS），他们在3到3天内两次评估了顶叶萎缩。每个月的时间来评估评估者内部协议。根据神经科医生的评分，所有评估者在25名认知正常的人的大脑MRI上评估了相同的50个顶叶，并且在所有萎缩程度中分布均匀，从无到显着。 结果：评分者内部一致性几乎完美，kappa值为0.90。评分者之间的共识为中度至实质性，kappa值介于0.43-0.86之间。 结论：顶叶萎缩评分是不同专业评估者中可靠的视觉量表，可在1-2分钟内通过脑MRI快速评估顶叶。我们认为它可以作为痴呆，尤其是早发性AD的鉴别诊断的辅助手段。

关键词: 顶叶萎缩评分，可靠性，视觉范围，脑磁共振成像，阿尔茨海默氏病，痴呆。

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