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Review Article

针对癌症和炎症多靶点的新型改良姜黄素衍生物的设计

卷 22, 期 5, 2021

发表于: 04 August, 2020

页: [573 - 589] 页: 17

弟呕挨: 10.2174/1389450121666200804113745

价格: $65

摘要

背景：姜黄素是姜黄的主要活性成分。在药物系中有1700多次引用，反映了姜黄素的多种生物学作用。这些生物活性中的大多数与分子的抗氧化，抗炎和抗肿瘤活性有关。一些报告提出天然姜黄素的各种靶标，包括生长因子，生长因子受体，细胞因子，酶和细胞凋亡的基因调节剂。这篇综述集中在针对癌症和炎症的改良姜黄素衍生物上。 方法：在本综述中，我们在临床前和临床研究中通过严格检查探索了基于姜黄素的抗癌药物。基于获得专利和非专利文献调查的强有力的科学报告，我们研究了姜黄素类分子与目标分子相互作用的方式。 结果：先进的研究在基因组水平上增加了癌细胞对姜黄素分子反应的新维度。但是，该分子的生物利用度差似乎是姜黄素的主要限制。数名研究人员已参与改进姜黄素衍生物的研究，以克服这一局限性。还讨论了针对包括多发性骨髓瘤，胰腺癌和结肠癌在内的各种癌症的临床试验的足够数据。 结论：综述了姜黄素基衍生物的构效关系（SAR）和常用合成方法的详细分析。利用计算机模拟的预测以及体外和体内研究的验证报告，得出了姜黄素的许多目标。其中，调节基于姜黄素的分子的与癌症相关的炎症基因是克服癌症的多模态治疗中的障碍的非常有希望的目标。

关键词: 癌症相关的炎症，药物靶标，抗炎，抗癌活性，姜黄素衍生物，构效关系（SAR）。

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