Abstract
The recent success of the human genome project and the continued accomplishment in obtaining DNA sequences for a vast array of organisms is providing an unprecedented wealth of information. Nevertheless, an abundance of the proteome contains hypothetical proteins or proteins of unknown function, where high throughput approaches for genome- wide functional annotation (functional genomics) has evolved as the necessary next step. Nuclear magnetic resonance spectroscopy is playing an important role in functional genomics by providing information on the structure of protein and protein-ligand complexes, from metabolite fingerprinting and profiling, from the analysis of the metabolome, and from ligand affinity screens to identify chemical probes.
Keywords: NMR, functional genomics, NMR high throughput screens, protein-ligand binding, protein-ligand co-structures, structural biology, structural genomics, NMR metabolomics, chemical proteomics, protein structure initiative
Combinatorial Chemistry & High Throughput Screening
Title: Functional Genomics and NMR Spectroscopy
Volume: 10 Issue: 8
Author(s): Robert Powers
Affiliation:
Keywords: NMR, functional genomics, NMR high throughput screens, protein-ligand binding, protein-ligand co-structures, structural biology, structural genomics, NMR metabolomics, chemical proteomics, protein structure initiative
Abstract: The recent success of the human genome project and the continued accomplishment in obtaining DNA sequences for a vast array of organisms is providing an unprecedented wealth of information. Nevertheless, an abundance of the proteome contains hypothetical proteins or proteins of unknown function, where high throughput approaches for genome- wide functional annotation (functional genomics) has evolved as the necessary next step. Nuclear magnetic resonance spectroscopy is playing an important role in functional genomics by providing information on the structure of protein and protein-ligand complexes, from metabolite fingerprinting and profiling, from the analysis of the metabolome, and from ligand affinity screens to identify chemical probes.
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Cite this article as:
Powers Robert, Functional Genomics and NMR Spectroscopy, Combinatorial Chemistry & High Throughput Screening 2007; 10 (8) . https://dx.doi.org/10.2174/138620707782507331
DOI https://dx.doi.org/10.2174/138620707782507331 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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