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Coronaviruses

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ISSN (Print): 2666-7967
ISSN (Online): 2666-7975

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Review Article

Coordinated Roadmap to Grip Pandemic COVID-19

Author(s): Rohini S. Kharwade and Sachin M. More*

Volume 2, Issue 4, 2021

Published on: 31 July, 2020

Page: [468 - 480] Pages: 13

DOI: 10.2174/2666796701999200801023110

Abstract

Coronavirus disease 2019 named COVID-19 caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been reported in Wuhan city of Hubei Province of China become a global pandemic. Genomic sequencing of SARS-CoV-2 unveils which showed multiple mutations relative to SARS-CoV. SARS-CoV-2 showed a very high receptor-binding domain (RBD) affinity towards the ACE-2 receptor in host cells, similar to SARS. Lack of immediate supervision and diagnostic measures hurdles prevention and treatment strategies against COVID-19. However, from SARS and MERS epidemics, WHO launched SOLIDARITY, a strategic and technical advisory group for infection hazards (STAG-IH) for the regular supervision and alert, which identified the estimated risk of COVID-19 and recommended the health emergence program to respond COVID-19. This article will briefly review the rationale history, structural genome with mutation, pathogenesis, preventive measure, and targeted treatment strategy to handle this pandemic COVID-19.

Keywords: COVID-19, SARS-Cov-2, ACE-2 receptor, social isolation, hydroxychloroquine, coronavirus disease.

Graphical Abstract

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