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Mini-Review Article

Falcipain-2 和 Falcipain-3 抑制剂作为有前景的抗疟药

卷 28, 期 15, 2021

发表于: 30 July, 2020

页: [3010 - 3031] 页: 22

弟呕挨: 10.2174/0929867327666200730215316

价格: $65

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摘要

疟疾仍然是全球公共卫生中的一个严重问题，特别是在南美洲以及非洲和亚洲的热带地区普遍存在。化疗实际上是治疗这种与贫困有关的疾病的唯一方法，因为目前还没有有效的疫苗。然而，对最常见的抗疟药物产生耐药性有时会使当前的治疗方案出现问题。因此，为新药发现过程确定新靶点是当务之急。在这种情况下，恶性疟原虫的 falcipain-2 和 falcipain-3 代表了寄生虫生命周期中的关键酶。 falcipain-2 和 falcipain-3 都参与血红蛋白水解，这是为寄生虫代谢需要提供游离氨基酸的重要途径。此外，falcipain-2 参与切割锚蛋白和条带 4.1 蛋白，它们是红细胞膜稳定性必不可少的细胞骨架元件。这篇综述文章重点介绍最新和最有效的 falcipain-2 和 falcipain-3 抑制剂，特别关注肽、拟肽或非肽抑制剂，它们靶向一种或两种疟疾半胱氨酸蛋白酶，对疟原虫具有一致的活性。恶性疟原虫。

关键词: Falcipain-2、falcipain-3、疟疾、恶性疟原虫、半胱氨酸蛋白酶抑制剂、治疗剂。

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