Abstract
Background: Grape (Vitis vinifera L.) is consumed by old-world populations in its natural form and is used to produce wine or juice. Currently, China is the largest grape producer in the world. The red grapes stand out because of their phytochemical composition, more specifically their high resveratrol levels. Resveratrol is a compound that has a number of different beneficial effects on health and is mainly used in the food and cosmetic industries. Grape peel is a waste product and new strategies based on nanotechnology can minimize its environmental impact and add value to this residue.
Objectives: The first objective of this study was to evaluate the technological potential of utilizing grape peel by researching and analyzing information extracted from patent documents filed worldwide in order to identify the main countries that hold the research technology, the main depositors and inventors, and the main areas of application. The second aim was to research and investigate grape peel products that have been created using nanotechnology. Methods: An analysis of all patented documents related to grape peel processes, products, or different industrial applications that may use nanotechnology was carried out. This was achieved by undertaking a Derwent Innovation Index (DII) database search. Results: A total of 752 patent documents were identified in the surveyed area. These were assessed for depositor country of origin, type of depositor, inventors, the evolution of deposits over time, and areas of application. Only 6% of the total represented products and processes in the nanotechnology area. There was a growth in the number of patent filings from 2015, which showed that the researched area is a current and developing technology with new application possibilities. The main depositing countries were China, the United States, and Japan, which dominate the researched technology. The identified documents discussed using the grape peel to develop new food, medical and dental products. Conclusion: Over the last few years, different approaches have been suggested for the production of nanoproducts based on grape peel. The results from this study showed that although incipient, nanotechnology is a promising area of research that can be explored by universities and companies because the products could have significant positive characteristics and, even though they are made out of a byproduct, have great application potential.Keywords: Vitis vinifera L., peel, bark, grape pomace, patents, biotechnology, technological prospecting.
Graphical Abstract
[http://dx.doi.org/10.1590/S0100-29452012000100017]
[http://dx.doi.org/10.1016/j.foodres.2019.01.011] [PMID: 31108820]
[http://dx.doi.org/10.1016/j.foodres.2015.09.029] [PMID: 28433296]
[http://dx.doi.org/10.1016/j.foodres.2010.05.001]
[http://dx.doi.org/10.3390/molecules18011076] [PMID: 23325097]
[http://dx.doi.org/10.1590/S0101-20612010000400030]
[http://dx.doi.org/10.1590/fst.25816]
[http://dx.doi.org/10.1021/jf025868i] [PMID: 12475269]
[http://dx.doi.org/10.1590/S0103-84782011000600027]
[http://dx.doi.org/10.1016/j.jfca.2006.04.010]
[http://dx.doi.org/10.1201/b22352-6]
[http://dx.doi.org/10.1016/j.supflu.2013.02.006]
[http://dx.doi.org/10.3390/molecules25071634] [PMID: 32252316]
[http://dx.doi.org/10.1016/S0002-8223(99)00314-4] [PMID: 10524397]
[http://dx.doi.org/10.1016/j.foodres.2017.11.082] [PMID: 29433270]
[http://dx.doi.org/10.1021/acs.jnatprod.7b00914] [PMID: 29565590]
[http://dx.doi.org/10.3390/nu11010113]
[http://dx.doi.org/10.1002/jsfa.8062] [PMID: 27696415]
[http://dx.doi.org/10.1016/j.carpath.2010.09.002] [PMID: 21130002]
[http://dx.doi.org/10.1089/jmf.2010.1264] [PMID: 21244239]
[http://dx.doi.org/10.1016/j.jada.2011.05.015] [PMID: 21802563]
[http://dx.doi.org/10.1111/j.1464-5491.2009.02727.x] [PMID: 19646193]
[http://dx.doi.org/10.1016/j.pnpbp.2008.03.024] [PMID: 18471948]
[http://dx.doi.org/10.1089/jmf.2012.2408] [PMID: 23437789]
[http://dx.doi.org/10.1016/j.jnutbio.2016.07.007] [PMID: 27560195]
[http://dx.doi.org/10.1016/j.wasman.2017.07.017] [PMID: 28734610]
[http://dx.doi.org/10.1111/ijfs.14100]
[http://dx.doi.org/10.1016/j.jfoodeng.2014.06.014]
[http://dx.doi.org/10.1166/asem.2016.1899]
[http://dx.doi.org/10.1590/S1981-67232013005000007]
[http://dx.doi.org/10.1002/fsn3.981] [PMID: 31139371]
[http://dx.doi.org/10.1016/j.jff.2018.11.051]
[http://dx.doi.org/10.1016/j.jtherbio.2019.04.007] [PMID: 31128648]
[http://dx.doi.org/10.3382/ps.2007-00297] [PMID: 18212374]
[http://dx.doi.org/10.1093/ps/86.3.508] [PMID: 17297163]
[http://dx.doi.org/10.1016/j.foodchem.2014.09.036] [PMID: 25442526]
[http://dx.doi.org/10.1016/j.microc.2013.12.014]
[http://dx.doi.org/10.1007/s13197-013-0991-1] [PMID: 25593367]
[http://dx.doi.org/10.1016/j.biopha.2017.02.049] [PMID: 28292018]
[http://dx.doi.org/10.1016/j.apt.2017.02.003]
[http://dx.doi.org/10.1515/chem-2019-0098]
[http://dx.doi.org/10.2174/1872208313666190522102518] [PMID: 31113349]
[http://dx.doi.org/10.1016/j.wpi.2005.10.004]
[http://dx.doi.org/10.1016/j.techfore.2017.11.012]
[http://dx.doi.org/10.1080/02648725.2003.10648045] [PMID: 14997854]
[http://dx.doi.org/10.1016/j.fbp.2013.08.010]
[http://dx.doi.org/10.1111/j.1365-2621.2012.03197.x]
[http://dx.doi.org/10.2174/1381612822666161227153906] [PMID: 28025943]
[http://dx.doi.org/10.1080/1040869059096] [PMID: 16047496]
[http://dx.doi.org/10.1080/15428052.2017.1363107]
[http://dx.doi.org/10.1080/10408390903044081] [PMID: 21108074]
[http://dx.doi.org/10.1201/b18459-4]
[http://dx.doi.org/10.1016/j.indcrop.2015.05.063]
[http://dx.doi.org/10.1016/j.foodres.2015.12.023]
[http://dx.doi.org/10.1155/2015/850902] [PMID: 25793210]
[http://dx.doi.org/10.1016/j.lwt.2010.06.024]
[http://dx.doi.org/10.1016/j.jclepro.2013.09.048]
[http://dx.doi.org/10.1016/j.indcrop.2017.10.012]
[http://dx.doi.org/10.1590/1517-869220162206163766]
[http://dx.doi.org/10.1016/j.appet.2019.104325] [PMID: 31228507]
[http://dx.doi.org/10.1016/j.ijgfs.2019.100172]
[http://dx.doi.org/10.1016/j.indcrop.2018.11.052]
[http://dx.doi.org/10.1016/j.msec.2016.04.050] [PMID: 27157761]
[http://dx.doi.org/10.2298/TSCI1904253T]
[http://dx.doi.org/10.1016/j.apm.2020.01.027]
[http://dx.doi.org/10.2298/TSCI1904189Y]
[http://dx.doi.org/10.2174/1872210513666190925160735] [PMID: 31553297]
[http://dx.doi.org/10.1016/j.carbpol.2018.03.023] [PMID: 29691028]
[http://dx.doi.org/10.1016/j.msec.2019.04.061] [PMID: 31147003]
[http://dx.doi.org/10.1080/15421406.2019.1578520]
[http://dx.doi.org/10.1002/cssc.200900220] [PMID: 19842157]
[http://dx.doi.org/10.1016/j.arabjc.2018.08.001]
[http://dx.doi.org/10.1016/j.jtice.2018.05.039]
[http://dx.doi.org/10.1016/j.foodhyd.2019.105554]
[http://dx.doi.org/10.1016/j.foodres.2018.10.083] [PMID: 31000260]