Login Register Cart 0
Generic placeholder image

Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Systematic Review Article

HIV-Tuberculous Meningitis Co-Infection: A Systematic Review and Meta-Analysis

Author(s): Ali Purmohamad, Taher Azimi, Mohammad J. Nasiri, Mehdi Goudarzi, Moein Zangiabadian, Hamid Sedighian and Abbas A.I. Fooladi*

Volume 22, Issue 7, 2021

Published on: 30 July, 2020

Page: [960 - 968] Pages: 9

DOI: 10.2174/1389201021666200730143906

Price: $65

Abstract

Human Immunodeficiency Virus (HIV)-infected persons are at a higher risk of developing Tuberculous Meningitis (TBM). We aimed to estimate the prevalence of TBM-HIV co-infection. We systematically searched Pubmed/Medline, Embase and Cochrane library databases from January 1, 2000, to January 31, 2017, to find relevant studies. We employed the random-effects meta-analysis model to estimate the pooled prevalence of TBM-HIV co-infection. Twenty-six eligible studies showed the prevalence of HIV in TBM patients. In the pooled analyses, the prevalence of HIV was 30% (95% CI: 12-47) in patients with confirmed TBM, and 12.1% (95% CI: 7.3-19.2) in patients with suspected TBM. This study shows a high prevalence of TBM-HIV co-infection. Establishing proper diagnostic criteria and preventive measures for TBM infections could assist in the prevention and management of TBM infection, particularly TBM-HIV co-infection.

Keywords: Meta-analysis, HIV, meningitis, Mycobacterium tuberculosis, TBM, prevention.

« Previous Next »
Graphical Abstract

[1]
Organization, W.H. Global tuberculosis report 2018. In Global tuberculosis report 2018, 2018.
[2]
Bahr, N.C.; Nuwagira, E.; Evans, E.E.; Cresswell, F.V.; Bystrom, P.V.; Byamukama, A.; Bridge, S.C.; Bangdiwala, A.S.; Meya, D.B.; Denkinger, C.M. Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: A prospective cohort study. Lancet Infect. Dis., 2018, 18(1), 68-75.
[3]
Azuaje, C.; Fernández, N.H.; Almirante, B.; Martín-Casabona, N.; Ribera, E.; Diaz, M.; Prats, G.; Pahissa, A. Tuberculous meningitis: A comparative study in relation to concurrent human immunodeficiency virus infection. Enferm. Infecc. Microbiol. Clin., 2006, 24(4), 245-250.
[4]
Brancusi, F.; Farrar, J.; Heemskerk, D. Tuberculous meningitis in adults: A review of a decade of developments focusing on prognostic factors for outcome. Future Microbiol., 2012, 7(9), 1101-1116.
[5]
Marais, S.; Pepper, D.J.; Marais, B.J.; Török, M.E. HIV-associated tuberculous meningitis-diagnostic and therapeutic challenges. Tuberculosis (Edinb.), 2010, 90(6), 367-374.
[6]
Liberati, A.; Altman, D.G.; Tetzlaff, J.; Mulrow, C.; Gøtzsche, P.C.; Ioannidis, J.P.; Clarke, M.; Devereaux, P.J.; Kleijnen, J.; Moher, D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: Explanation and elaboration. Ann. Intern. Med., 2009, 151(4), W-65-W-94.
[7]
Munn, Z.; Moola, S.; Riitano, D.; Lisy, K. The development of a critical appraisal tool for use in systematic reviews: Addressing questions of prevalence. Int. J. Health Policy Manag., 2014, 3, 123.
[8]
Nagdev, K.J.; Kashyap, R.S.; Parida, M.M.; Kapgate, R.C.; Purohit, H.J.; Taori, G.M.; Daginawala, H.F. Loop-mediated isothermal amplification for rapid and reliable diagnosis of tuberculous meningitis. J. Clin. Microbiol., 2011, 49(5), 1861-1865.
[9]
Nagdev, K.J.; Kashyap, R.S.; Deshpande, P.S.; Purohit, H.J.; Taori, G.M.; Daginawala, H.F. Determination of polymerase chain reaction efficiency for diagnosis of tuberculous meningitis in Chelex-100® extracted DNA samples. Int. J. Tuberc. Lung Dis., 2010, 14(8), 1032-1038.
[10]
Nhu, N.T.Q.; Heemskerk, D.; Chau, T.T.H.; Mai, N.T.H.; Nghia, H.D.T.; Loc, P.P.; Ha, D.T.M.; Merson, L.; Van Thinh, T.T.; Day, J. Evaluation of GeneXpert MTB/RIF for diagnosis of tuberculous meningitis. J. Clin. Microbiol., 2014, 52(1), 226-233.
[11]
Patel, V.B.; Theron, G.; Lenders, L.; Matinyena, B.; Connolly, C.; Singh, R.; Coovadia, Y.; Ndung’u, T.; Dheda, K. Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous meningitis in a high burden setting: A prospective study. PLoS Med., 2013, 10(10), e1001536.
[12]
Patel, V.B.; Singh, R.; Connolly, C.; Coovadia, Y.; Peer, A.K.; Parag, P.; Kasprowicz, V.; Zumla, A.; Ndung’u, T.; Dheda, K. Cerebrospinal T-cell responses aid in the diagnosis of tuberculous meningitis in a human immunodeficiency virus-and tuberculosis-endemic population. Am. J. Respir. Crit. Care Med., 2010, 182(4), 569-577.
[13]
Chaidir, L.; Ganiem, A.R. vander Zanden, A.; Muhsinin, S.; Kusumaningrum, T.; Kusumadewi, I.; van der Ven, A.; Alisjahbana, B.; Parwati, I.; van Crevel, R. Comparison of real time IS 6110-PCR, microscopy, and culture for diagnosis of tuberculous meningitis in a cohort of adult patients in Indonesia. PLoS One, 2012, 7(12), e52001.
[14]
Solomons, R.; Visser, D.; Friedrich, S.; Diacon, A.; Hoek, K.; Marais, B.; Schoeman, J.; van Furth, A. Improved diagnosis of childhood tuberculous meningitis using more than one nucleic acid amplification test. Int. J. Tuberc. Lung Dis., 2015, 19(1), 74-80.
[15]
Sardella, I.G.; Singh, M.; Kumpfer, S.; Heringer, R.R.; Saad, M.H.F.; Sohler, M.P. Evaluation of Lionex TB kits and mycobacterial antigens for IgG and IgA detection in cerebrospinal fluid from tuberculosis meningitis patients. Mem. Inst. Oswaldo Cruz., 2010, 105(5), 722-728.
[16]
Thomas, M.; Hinks, T.; Raghuraman, S.; Ramalingam, N.; Ernst, M.; Nau, R.; Lange, C.; Kösters, K.; Gnanamuthu, C.; John, G. Rapid diagnosis of Mycobacterium tuberculosis meningitis by enumeration of cerebrospinal fluid antigen-specific T-cells. Int. J. Tuberc. Lung Dis., 2008, 12(6), 651-657.
[17]
Thwaites, G.; Chau, T.; Stepniewska, K.; Phu, N.; Chuong, L.; Sinh, D.; White, N.; Parry, C.; Farrar, J. Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. Lancet, 2002, 360(9342), 1287-1292.
[18]
Thwaites, G.E.; Chau, T.T.H.; Farrar, J.J. Improving the bacteriological diagnosis of tuberculous meningitis. J. Clin. Microbiol., 2004, 42(1), 378-379.
[19]
Thwaites, G.E.; Bang, N.D.; Dung, N.H.; Quy, H.T.; Oanh, D.T.T.; Thoa, N.T.C.; Hien, N.Q.; Thuc, N.T.; Hai, N.N.; Lan, N.T.N. Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N. Engl. J. Med., 2004, 351(17), 1741-1751.
[20]
Kim, S.-H.; Cho, O.-H.; Park, S.-J.; Lee, E.M.; Kim, M.-N.; Lee, S.-O.; Choi, S-H.; Kim, Y.S.; Woo, J.H.; Lee, S-A. Rapid diagnosis of tuberculous meningitis by T cell-based assays on peripheral blood and cerebrospinal fluid mononuclear cells. Clin. Infect. Dis., 2010, 50(10), 1349-1358.
[21]
Parra-Ruiz, J.; Ramos, V.; Dueñas, C.; Coronado-Álvarez, N.; Cabo-Magadán, R.; Portillo-Tuñón, V.; Vinuesa, D.; Muñoz-Medina, L.; Hernández-Quero, J. Rational application of adenosine deaminase activity in cerebrospinal fluid for the diagnosis of tuberculous meningitis. Infection, 2015, 43(5), 531-535.
[22]
Solari, L.; Soto, A.; Agapito, J.C.; Acurio, V.; Vargas, D.; Battaglioli, T.; Accinelli, R.A.; Gotuzzo, E.; Van Der Stuyft, P. The validity of cerebrospinal fluid parameters for the diagnosis of tuberculous meningitis. Int. J. Infect. Dis., 2013, 17(12), e1111-e1115.
[23]
Bonington, A.; Strang, J.; Klapper, P.; Hood, S.; Parish, A.; Swift, P.; Damba, J.; Stevens, H.; Sawyer, L.; Potgieter, G.TB PCR in the early diagnosis of tuberculous meningitis: Evaluation of the Roche semi-automated COBAS Amplicor MTB test with reference to the manual Amplicor MTB PCR test. Tuber. Lung Dis., 2000, 80(4), 191-196.
[24]
Feng, G.-D.; Shi, M.; Ma, L.; Chen, P.; Wang, B.-J.; Zhang, M.; Chang, X.-l.; Su, X.-C.; Yang, Y.-N.; Fan, X.-H. Diagnostic accuracy of intracellular Mycobacterium tuberculosis detection for tuberculous meningitis. Am. J. Respir. Crit. Care Med., 2014, 189(4), 475-481.
[25]
Bhigjee, A.I.; Padayachee, R.; Paruk, H.; Hallwirth-Pillay, K.D.; Marais, S.; Connoly, C. Diagnosis of tuberculous meningitis: Clinical and laboratory parameters. Int. J. Infect. Dis., 2007, 11(4), 348-354.
[26]
Dora, J.M.; Geib, G.; Chakr, R.; Paris, F.D.; Mombach, A.B.; Lutz, L.; Souza, C.F.M.D.; Goldani, L.Z. Polymerase chain reaction as a useful and simple tool for rapid diagnosis of tuberculous meningitis in a Brazilian tertiary care hospital. Braz. J. Infect. Dis., 2008, 12(3), 245-247.
[27]
Youssef, F.G.; Afifi, S.A.; Azab, A.M.; Wasfy, M.M.; Abdel-Aziz, K.M.; Parker, T.M.; Oun, S.A.; Jobanputra, N.N.; Hajjeh, R.A. Differentiation of tuberculous meningitis from acute bacterial meningitis using simple clinical and laboratory parameters. Diagn. Microbiol. Infect. Dis., 2006, 55(4), 275-278.
[28]
Kashyap, R.S.; Ramteke, S.S.; Morey, S.H.; Purohit, H.J.; Taori, G.M.; Daginawala, H. Diagnostic value of early secreted antigenic target-6 for the diagnosis of tuberculous meningitis patients. Infection, 2009, 37(6), 508-513.
[29]
San Juan, R.; Sánchez-Suárez, C.; Rebollo, M.J.; Folgueira, D.; Palenque, E.; Ortuño, B.; Lumbreras, C.; Aguado, J.M. Interferon γ quantification in cerebrospinal fluid compared with PCR for the diagnosis of tuberculous meningitis. J. Neurol., 2006, 253(10), 1323-1330.
[30]
Sinha, M.K.; Garg, R.K.; Anuradha, H.; Agarwal, A.; Singh, M.K.; Verma, R.; Shukla, R. Vision impairment in tuberculous meningitis: Predictors and prognosis. J. Neurol. Sci., 2010, 290(1), 27-32.
[31]
Chan, K.; Cheung, R.; Fong, C.; Tsang, K.; Mak, W.; Ho, S. Clinical relevance of hydrocephalus as a presenting feature of tuberculous meningitis. QJM, 2003, 96(9), 643-648.
[32]
Cagatay, A.; Ozsut, H.; Gulec, L.; Kucukoglu, S.; Berk, H.; Ince, N.; Ertugrul, B.; Aksoz, S.; Akal, D.; Eraksoy, H. Tuberculous meningitis in adults-experience from Turkey. Int. J. Clin. Pract., 2004, 58(5), 469-473.
[33]
Marais, S.; Pepper, D.J.; Schutz, C.; Wilkinson, R.J.; Meintjes, G. Presentation and outcome of tuberculous meningitis in a high HIV prevalence setting. PLoS One, 2011, 6(5), e20077.
[34]
Organization, W.H. Global tuberculosis report 2013; World Health Organization, 2013.
[35]
Luma, H.N.; Tchaleu, B.C.N.; Ngahane, B.H.M.; Temfack, E.; Doualla, M.S.; Halle, M.P.; Joko, H.A.; Koulla-Shiro, S. Tuberculous meningitis: Presentation, diagnosis and outcome in HIV-infected patients at the douala general hospital, Cameroon: A cross sectional study. AIDS Res. Ther., 2013, 10(1), 16.
[36]
Békondi, C.; Bernede, C.; Passone, N.; Minssart, P.; Kamalo, C.; Mbolidi, D.; Germani, Y. Primary and opportunistic pathogens associated with meningitis in adults in Bangui, Central African Republic, in relation to human immunodeficiency virus serostatus. Int. J. Infect. Dis., 2006, 10(5), 387-395.
[37]
Davis, A.G.; Rohlwink, U.K.; Proust, A.; Figaji, A.A.; Wilkinson, R.J. The pathogenesis of tuberculous meningitis. J. Leukoc. Biol., 2019, 105(2), 267-280.
[38]
Marais, S.; Thwaites, G.; Schoeman, J.F.; Török, M.E.; Misra, U.K.; Prasad, K.; Donald, P.R.; Wilkinson, R.J.; Marais, B.J. Tuberculous meningitis: A uniform case definition for use in clinical research. Lancet Infect. Dis., 2010, 10(11), 803-812.
[39]
Pormohammad, A.; Nasiri, M.J.; McHugh, T.D.; Riahi, S.M.; Bahr, N.C. A systematic review and meta-analysis of the diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis. J. Clin. Microbiol., 2019, 57(6), e01113-e01118.
[40]
Chesdachai, S.; Katz, B.; Sapkota, S. Diagnostic challenges and dilemmas in tuberculous meningitis. Am. J. Med. Sci., 2020, 359(6)
[41]
van der Weert, E.M.; Hartgers, N.M.; Schaaf, H.S.; Eley, B.S.; Pitcher, R.D.; Wieselthaler, N.A.; Laubscher, R.; Donald, P.R.; Schoeman, J.F. Comparison of diagnostic criteria of tuberculous meningitis in human immunodeficiency virus-infected and uninfected children. Pediatr. Infect. Dis. J., 2006, 25(1), 65-69.
[42]
Lan, S.H.; Chang, W.N.; Lu, C.H.; Lui, C.C.; Chang, H.W. Cerebral infarction in chronic meningitis: A comparison of tuberculous meningitis and cryptococcal meningitis. Qjm, 2001, 94(5), 247-253.
[43]
Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D.G. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Int. J. Surg., 2010, 8(5), 336-341.

Rights & Permissions Print Cite
Article Metrics
17
1
© 2024 Bentham Science Publishers | Privacy Policy