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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Rapid Cesium Fluoride Catalyzed Synthesis of 5-Aryloxy-1-phenyl-1Htetrazoles via Nucleophilic Aromatic Substitution

Author(s): Khalid Mohammed Khan*, Itrat Fatima, Shahnaz Perveen and Syed Muhammad Saad

Volume 18, Issue 5, 2021

Published on: 28 July, 2020

Page: [389 - 394] Pages: 6

DOI: 10.2174/1570178617999200728211046

Price: $65

Abstract

A nucleophilic aromatic substitution via a new and facile cesium fluoride catalyzed synthetic approach to get 5-aryloxy-1-phenyl-1H-tetrazoles was developed. Dual usage of cesium fluoride as a nucleophilic catalyst as well as an electrophilic catalyst afforded the desired products at room temperature in a short reaction time without purification in high yields. This simple but useful reaction may be a rapid and reliable strategy for the synthesis of tetrazolyl ethers.

Keywords: Tetrazole, diaryl ether, nucleophilic aromatic substitution, cesium fluoride, catalysis, methodology.

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