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General Review Article

轻度到中度溃疡性结肠炎的“靶向治疗”:支持这一策略的证据

卷 22, 期 1, 2021

发表于: 27 July, 2020

页: [117 - 125] 页: 9

弟呕挨: 10.2174/1389450121666200727120305

价格: $65

摘要

背景：对慢性疾病，尤其是风湿病和糖尿病的管理现在纳入了一项“治疗到目标”战略，即治疗的目的是实现客观的结果。这也适用于溃疡性结肠炎(UC)。靶点被证明可以预防内器官功能障碍，特别是肠损伤及其并发症，最后是结肠直肠癌。最近，科学界试图在目前推荐的目标之外，进一步定义粘膜愈合和临床缓解。在UC中前瞻性研究这种方法的研究很少，而且在日常临床实践中也没有常规使用治疗-靶向(T2T)算法。 目的：我们的目的是回顾目前在UC中进行T2T治疗的证据，并讨论其在常规临床实践和临床试验中的应用。 方法：从2020年2月进行PubMed搜索，通过确定已发表的论文，调查UC的目标达成率。 结果：轻中度UC通过批准的药物可达到不同的目标;与长期预后相关，组织学缓解正成为一个强有力的目标。 结论：需要进一步的研究来比较T2T治疗策略和传统治疗，特别是在轻度到中度疾病谱系中。

关键词: 溃疡性结肠炎，组织学愈合，粘膜愈合，炎症，靶向，缓解。

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