摘要
多形性胶质母细胞瘤(GBM;IV级星形细胞瘤)诱导大脑中星形胶质细胞肿瘤。它是一种快速生长的肿瘤,会扩散到附近的大脑区域,特别是大脑半球的额叶和颞叶。GBM的病因尚不清楚,但主要的危险因素是神经纤维瘤病和神经鞘瘤病等遗传疾病,它们在神经系统中发展为肿瘤。化疗治疗GBM导致耐药,目前的替莫唑胺(Temozolomide, TMZ)等药物治疗效果较差。药物失败的原因是细胞周期中DNA烷基化酶和线粒体功能障碍。从植物中天然产生的生物活性化合物,即植物化学物质,是抗癌药物的重要来源。一些典型的例子包括紫杉醇类似物、长春新碱、长春碱、鬼叶草毒素类似物、喜树碱、姜黄素、芦荟大黄素、槲皮素、小檗碱等。这些植物化学物质通常调节不同的分子途径,这些途径涉及到癌症的生长和进展。然而,BBB/BBTB的存在限制了这些植物化学物质的通过,最终导致了它们的低生物利用度和相对毒性。在这篇综述中,我们将纳米技术作为一种新型的药物传递系统,将传统药物中的植物化学物质传递到大脑的特定部位,以治疗GBM。
关键词: 多形性胶质母细胞瘤,纳米技术,纳米药物,植物化学,靶向药物传递,传统药物,血脑肿瘤屏障
图形摘要
Current Drug Targets
Title:Management of Glioblastoma Multiforme by Phytochemicals: Applications of Nanoparticle-Based Targeted Drug Delivery System
Volume: 22 Issue: 4
关键词: 多形性胶质母细胞瘤,纳米技术,纳米药物,植物化学,靶向药物传递,传统药物,血脑肿瘤屏障
摘要: The Glioblastoma Multiforme (GBM; grade IV astrocytoma) exhorts tumors of star-shaped glial cells in the brain. It is a fast-growing tumor that spreads to nearby brain regions specifically to cerebral hemispheres in frontal and temporal lobes. The etiology of GBM is unknown, but major risk factors are genetic disorders like neurofibromatosis and schwannomatosis, which develop the tumor in the nervous system. The management of GBM with chemo-radiotherapy leads to resistance, and current drug regimen like Temozolomide (TMZ) is less efficacious. The reasons behind the failure of drugs are due to DNA alkylation in the cell cycle by enzyme DNA guanidase and mitochondrial dysfunction. Naturally occurring bioactive compounds from plants referred as phytochemicals, serve as vital sources for anti-cancer drugs. Some prototypical examples include taxol analogs, vinca alkaloids (vincristine, vinblastine), podophyllotoxin analogs, camptothecin, curcumin, aloe-emodin, quercetin, berberine etc. These phytochemicals often regulate diverse molecular pathways, which are implicated in the growth and progression of cancers. However, the challenges posed by the presence of BBB/BBTB to restrict the passage of these phytochemicals, culminates in their low bioavailability and relative toxicity. In this review, we integrated nanotech as a novel drug delivery system to deliver phytochemicals from traditional medicine to the specific site within the brain for the management of GBM.
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Cite this article as:
Management of Glioblastoma Multiforme by Phytochemicals: Applications of Nanoparticle-Based Targeted Drug Delivery System, Current Drug Targets 2021; 22 (4) . https://dx.doi.org/10.2174/1389450121666200727115454
DOI https://dx.doi.org/10.2174/1389450121666200727115454 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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