Mesenchymal Stem Cells Seeded Decellularized Tendon Scaffold for Tissue Engineering

Title:Mesenchymal Stem Cells Seeded Decellularized Tendon Scaffold for Tissue Engineering

Volume: 16 Issue: 2

Author(s): Niveditha K, Vineeth CA, Josna Joseph, Arun U, Annie John and Annie Abraham*

Affiliation:

• Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala 695581,India

Keywords: Achilles tendon injuries, mesenchymal stem cells, decellularization, scaffolds, tissue engineering, potentials.

Abstract: Tendon is a collagenous tissue to connect bone and muscle. Healing of damaged/injured tendon is the primary clinical challenge in musculoskeletal regeneration because they often react poorly to treatment. Tissue engineering (a triad strategy of scaffolds, cells and growth factors) may have the potential to improve the quality of tendon tissue healing under such impaired situations. Tendon tissue engineering aims to synthesize graft alternatives to repair the injured tendon. Biological scaffolds derived from decellularized tissue may be a better option as their biomechanical properties are similar to the native tissue. This review is designed to provide background information on the current challenges in curing torn/worn out the tendon and the clinical relevance of decellularized scaffolds for such applications.

Cite this article as:

K Niveditha , CA Vineeth , Joseph Josna , U Arun , John Annie and Abraham Annie *, Mesenchymal Stem Cells Seeded Decellularized Tendon Scaffold for Tissue Engineering, Current Stem Cell Research & Therapy 2021; 16 (2) . https://dx.doi.org/10.2174/1574888X15666200723123901