A Simple and Efficient Protocol for the Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-Ones Catalyzed by Succinic Acid Using Water as Green Reaction Medium

Ramesh    S.    Ghogare; Kalpana       Patankar-Jain; Sana    Amir Hamzah    Momin

doi:10.2174/1570178617999200721011300

Abstract

A simple and efficient protocol has been established to the synthesis of 3,4-disubstituted isoxazol-5(4H)-ones via Knoevenagel condensation reaction. In this synthesis, succinic acid was used as an inexpensive catalyst and water as a green reaction medium. This method is useful for the preparat ion of various derivatives of 3,4-disubstituted isoxazol-5(4H)-ones in excellent yields.

Keywords: Succinic acid, 3, 4-disubstituted isoxazol-5(4H)-ones, Aromatic aldehydes, Ethyl acetoacetate, hydroxylamine hydrochloride, Knoevenagel condensation.

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DOI https://dx.doi.org/10.2174/1570178617999200721011300	Print ISSN 1570-1786
Publisher Name Bentham Science Publisher	Online ISSN 1875-6255

Letters in Organic Chemistry

A Simple and Efficient Protocol for the Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-Ones Catalyzed by Succinic Acid Using Water as Green Reaction Medium

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