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Review Article

Tridax Procumbens黄酮类化合物治疗骨质疏松症的治疗和机制方法

卷 21, 期 16, 2020

页: [1687 - 1702] 页: 16

弟呕挨: 10.2174/1389450121666200719012116

价格: $65

摘要

破骨细胞的骨吸收活性与成骨细胞的成骨能力之间的平衡活性密切地调节着骨的稳态。多核破骨细胞降解骨基质，并与成骨细胞协同参与动态骨重塑。这些细胞之间的这种调节平衡的破坏或由高于骨骼构造的更高吸收率引起的骨骼重塑的任何失衡都会导致包括骨矿物质密度（BMD）在内的骨基质减少。这些破骨细胞显着的作用在包括骨质疏松症和类风湿性关节炎（RA）在内的几种与骨骼相关的疾病中导致骨折和关节拆除的风险较高。 Tridax procumbens是一种非常有趣的多年生植物，其二级代谢产物在这里称为T. procumbens黄酮类化合物（TPFs），由于各种治疗方法，例如抗炎，抗贫血和抗糖尿病作用，是众所周知的植物化学制剂。这篇综述的重点是针对TPF在治疗骨相关疾病方面的药用特性和作用机理的系统性公约。根据当前的文献，该综述为基础研究人员和临床医生提供了基于证据的TPF信息，以预防和治疗包括骨质疏松症在内的骨相关疾病。它还强调了医学研究的意义，需要进行更多的研究来了解TPF的细胞信号通路对骨重构的调控，并讨论可能的有希望的民族植物学资源，该资源可以传达临床前和临床线索，以开发下一代治疗骨相关的治疗剂。失调。

关键词: TPF，骨骼重塑，破骨细胞分化，骨质疏松症，NFATc1，骨矿物质密度（BMD）。

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