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Review Article

前列腺癌手术后药物对ΟΑΒ起作用吗

卷 21, 期 15, 2020

页: [1515 - 1526] 页: 12

弟呕挨: 10.2174/1389450121666200716202103

价格: $65

摘要

有证据表明，根治性前列腺切除术（RP后）失禁不仅仅是外部尿道括约肌机制不足。多达三分之一的RP后尿失禁的男性患有膀胱功能障碍，即膀胱过度活动症（OAB）。 OAB是一种复杂的症状综合征，病理生理学定义不清。它给患者带来了沉重的负担，对他们的生活质量产生了负面影响，其管理可能很困难且具有挑战性。 RP后OAB的发生率在15.2至37.8％之间。病因是多方面的，包括膀胱部分分散，逼尿肌功能不全，膀胱出口梗阻以及压力性尿失禁（SUI）并存。 RP后SUI可能导致膀胱功能失调和尿道静脉反射的激活，进而使RP后尿失禁恶化。 RP-OAB后男性的诊断检查应旨在识别潜在的病因，并对治疗方案进行个性化设置。到目前为止，还没有来自文献的可靠的数据来进行RP后OAB管理。似乎抗胆碱能药和PDE5抑制剂可有效改善OAB参数。

关键词: 膀胱过度活动症，急迫性尿失禁，前列腺癌根治术，前列腺癌，尿急，混合性尿失禁。

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