Abstract
The search for technological applications for oils has been growing largely due to their potential nutritional and economic applications. Encapsulation makes it possible to reduce the disadvantages of oils, such as physical instability or thermodynamics, or to improve their technological properties, enabling their use in various industrial areas. Nanoencapsulated oils have the potential to improve oil bioavailability and achieve controlled release and are able to target bioactive compounds with greater precision than microencapsulated oils. The present study aims to evaluate the primary characteristics and profiles of the technological prospection of oil nanoparticles. This technology foresight study investigates the patenting activity and the academic literature to map out the technological progress and difficulties in the area of nanoencapsulation. Exponential growth in patent filing was noted with a peak in 2017, with China filing the highest number of patents. Regarding the area of application, the food industry was most common followed by the pharmaceutical industry. The most commonly used terms in patent documents on the subject were nanoemulsion and nanoparticle. The most commonly used oil, technique, wall materials and emulsifiers were soybean oil, emulsification, chitosan and lecithin, and Span 80, Tween 80 and Tween 40, respectively. The obtained articles were typically patent documents. The main depositor was Jiangnan University, and most inventors filed the same number of patent documents. Nanoencapsulation of oils has many known advantages that have been widely published in the literature and used by industry. There is a trend in the growth of patent document deposits and related scientific publications, indicating that many innovations have been made, highlighting the importance of oil nanoencapsulation.
Keywords: Oil nanoencapsulation, nanotechnology, patent documents, innovation, prospective technology, technology protection.
Graphical Abstract
[1]
Leal F, Bágio J. Study of thermal degradation of cotton oil frying process . Completion of course work, Federal University of Rio Grande: Rio Grande, November. 2017.
[2]
Brasil. National Health Surveillance Agency Resolution of Collegiate Board – RDC nº 270 2005. Available at:; http://bvsms.saude.gov.br/bvs/saudelegis/anvisa/2005/rdc0270_22_09_2005.html[Accessed October 15, 2019]. .
[3]
FAS; Oilseeds: World Markets and Trade 2019. Foreign Agricultural Service. United States Department of Agriculture (USDA). [Accessed October 15, 2019]..
[4]
Castro LS. Analyzing the substitutability in the world market for vegetable oils via price transmission. J Contemporânea Econom Gestão 2016; 14(3): 79-93.
[http://dx.doi.org/10.19094/contextus.v14i3.850]
[http://dx.doi.org/10.19094/contextus.v14i3.850]
[5]
Pinho DMM, Suarez PAZA. Hydrogenation of oils and fats and your industrial applications. Rev Virtual Quim 2013; 5(1): 47-62.
[6]
Patel R, Velikov KPR. Zein as a source of functional colloidal nano- and microstructures. Curr Opin Colloid Interface Sci 2014; 19(5): 450-8.
[7]
Mohammadi A, Hashemi M, Hosseini SM. Nanoencapsulation of Zataria multiflora essential oil preparation and characterization with enhanced antifungal activity for controlling Botrytis cinerea, the causal agent of gray mould disease. Innov Food Sci Emerg Technol 2015; 28(5): 73-80.
[http://dx.doi.org/10.1016/j.ifset.2014.12.011]
[http://dx.doi.org/10.1016/j.ifset.2014.12.011]
[8]
Yang FL, Li XG, Zhu F, Lei CL. Structural characterization of nanoparticles loaded with garlic essential oil and their insecticidal activity against Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae). J Agric Food Chem 2009; 57(21): 10156-62.
[http://dx.doi.org/10.1021/jf9023118] [PMID: 19835357]
[http://dx.doi.org/10.1021/jf9023118] [PMID: 19835357]
[9]
Assis LM, Zavareze ER, Hernández CP, Souza LAS. Review: Characteristics of nanoparticles and potential applications in food. Braz J Food Technol 2012; 15(2): 99-109.
[http://dx.doi.org/10.1590/S1981-67232012005000004]
[http://dx.doi.org/10.1590/S1981-67232012005000004]
[10]
Daudt RM, Emanuelli J, Guerreiro ICK, Pohlmann AR, Guterres SS. Nanotechnology as a strategy for the development of cosmetics. Cienc Cult 2013; 65(3): 28-31.
[http://dx.doi.org/10.21800/S0009-67252013000300011]
[http://dx.doi.org/10.21800/S0009-67252013000300011]
[11]
Bazana MT, Codevilla CF, Silva CB, Menezes CR. Lycopene nanoencapsulation in food. Ciênc Nat 2015; 37: 38-48.
[http://dx.doi.org/10.5902/2179460X19713]
[http://dx.doi.org/10.5902/2179460X19713]
[12]
Barreto A. coating materials used in the microencapsulation of probiotics. Ciênc Nat 2015; 37: 164-74.
[13]
Peters R, Dam GT, Bouwmeester H, et al. Identification and characterization of organic nanoparticles in food. Trends Analyt Chem 2011; 30(1): 100-12.
[http://dx.doi.org/10.1016/j.trac.2010.10.004]
[http://dx.doi.org/10.1016/j.trac.2010.10.004]
[14]
Bazana T, Codevilla C, Menezes C. Nanoencapsulation of bioactive compounds: Challenges and perspectives. Curr Opin Food Sci 2019; 26: 47-56.
[http://dx.doi.org/10.1016/j.cofs.2019.03.005]
[http://dx.doi.org/10.1016/j.cofs.2019.03.005]
[15]
Moreira GEG. Obtaining and characterizing a microencapsulated extract of acerola agroindustrial residue Master Thesis, Federal University of Rio Grande do Norte: Rio Grande do Norte, March. 2007.
[16]
Sheikholeslami M, Milad D, Zhixiong L. Experimental investigation for entropy generation and exergy loss of nano-refrigerant condensation process. Int J Heat Mass Transf 2018; 125: 1087-95.
[http://dx.doi.org/10.1016/j.ijheatmasstransfer.2018.04.155]
[http://dx.doi.org/10.1016/j.ijheatmasstransfer.2018.04.155]
[17]
Sheikholeslami M, Jafaryar M, Hedaya M, et al. Heat transfer and turbulent simulation of nanomaterial due to compound turbulator including irreversibility analysis. Int J Heat Mass Transf 2019; 137: 1290-300.
[http://dx.doi.org/10.1016/j.ijheatmasstransfer.2019.04.030]
[http://dx.doi.org/10.1016/j.ijheatmasstransfer.2019.04.030]
[18]
Nithyadevi N, Shamadhani A, Hakan F, Abu-Hamdeh N. Mixed convection analysis in heat transfer enhancement of a nanofluid filled porous enclosure with various wall speed ratios. Int J Heat Mass Transf 2017; 113: 716-29.
[http://dx.doi.org/10.1016/j.ijheatmasstransfer.2017.05.134]
[http://dx.doi.org/10.1016/j.ijheatmasstransfer.2017.05.134]
[19]
Sheikholeslami M, Rizwan-ul H, Shafee A, Zhixiong L. Heat transfer behavior of Nanoparticle enhanced PCM solidification through an enclosure with V shaped fins. Int J Heat Mass Transf 2019; 130: 1322-42.
[http://dx.doi.org/10.1016/j.ijheatmasstransfer.2018.11.020]
[http://dx.doi.org/10.1016/j.ijheatmasstransfer.2018.11.020]
[20]
Laranjeira SP. Rosemarinus essential oil nanoencapsulation officialis with PEG: Study of the effect of molar masses of PEG..
[21]
Anandharamakrishnan C. Techniques for Formation of Nanoemulsions.In Techniques for Nanoencapsulation of Food IngredientsSpringer: New York. 2014; pp. 1-16.
[22]
Ghorbanzade T, Jafari SM, Akhavan S, Hadavi R. Nano-encapsulation of fish oil in nano-liposomes and its application in fortification of yogurt. Food Chem 2017; 216: 146-52.
[http://dx.doi.org/10.1016/j.foodchem.2016.08.022 ] [PMID: 27596403]
[http://dx.doi.org/10.1016/j.foodchem.2016.08.022 ] [PMID: 27596403]
[23]
de Campo C, Dos Santos PP, Costa TMH, et al. Nanoencapsulation of chia seed oil with chia mucilage (Salvia hispanica L.) as wall material: Characterization and stability evaluation. Food Chem 2017; 234: 1-9.
[http://dx.doi.org/10.1016/j.foodchem.2017.04.153 ] [PMID: 28551210]
[http://dx.doi.org/10.1016/j.foodchem.2017.04.153 ] [PMID: 28551210]
[24]
Hasani S, Ojagh SM, Ghorbani M. Nanoencapsulation of lemon essential oil in Chitosan-Hicap system. Part 1: Study on its physical and structural characteristics. Int J Biol Macromol 2018; 115: 143-51.
[http://dx.doi.org/10.1016/j.ijbiomac.2018.04.038] [PMID: 29653169]
[http://dx.doi.org/10.1016/j.ijbiomac.2018.04.038] [PMID: 29653169]
[25]
da Silva Stefani F, de Campo C, Paese K, Staniscuaski GS, Haas CTM, Hickmann FS. Nanoencapsulation of linseed oil with chia mucilage as structuring material: Characterization, stability and enrichment of orange juice. Food Res Int 2019; 120: 872-9.
[http://dx.doi.org/10.1016/j.foodres.2018.11.052] [PMID: 31000308]
[http://dx.doi.org/10.1016/j.foodres.2018.11.052] [PMID: 31000308]
[26]
Ghasemi S, Jafari SM, Assadpour E, Khomeiri M. Production of pectin-whey protein nano-complexes as carriers of orange peel oil. Carbohydr Polym 2017; 177: 369-77.
[http://dx.doi.org/10.1016/j.carbpol.2017.09.009] [PMID: 28962781]
[http://dx.doi.org/10.1016/j.carbpol.2017.09.009] [PMID: 28962781]
[27]
Leidy R, Flores MJP, Martinez A, Carvajal MXQ. Production of high-oleic palm oil nanoemulsions by high-shear homogenization (microfluidization). Innov Food Sci Emerg Technol 2019; 35: 75-85.
[28]
Linhares AMF, Grando RL, Borges CP, da Fonseca FV. Technological prospection on membranes containing silver nanoparticles for water disinfection. Recent Pat Nanotechnol 2018; 12(1): 3-12.
[http://dx.doi.org/10.2174/1872210511666170920144342 ] [PMID: 28933268]
[http://dx.doi.org/10.2174/1872210511666170920144342 ] [PMID: 28933268]
[29]
Auweter H, Bohn H, Haberkorn H, Horn D, Lueddecke E, Rauschenberger V. Production of carotenoid preparations in the form of coldwater-dispersible powders, and the use of the novel carotenoid
preparations Depositante: BASF AKTIENGESELLSCHAFT US5968251 (A) Depósito: 13 set 1996 Concessão: 19out. 1999.
[30]
Joannopoulos JD. Institute for Soldier Nanotechnologies http://web.mit.edu/annualreports/pres14/2014.18.06.pdf [Accessed October 20, 2019]..
[31]
Vasconcelos L. Tecnologia - The invisible revolution. Development Challenges. IPEA 2004; 5(1): 1-1.
[32]
Quintella CM, Teixeira LSG, Korn MGA, et al. Biodiesel chain from bench to industry: An overview with prospecting tasks and opportunities for R & D & I. Quim Nova 2009; 32: 793-808.
[http://dx.doi.org/10.1590/S0100-40422009000300022]
[http://dx.doi.org/10.1590/S0100-40422009000300022]
[33]
INPI. Classificação Cooperativa de Patentes (CPC) - Introdução.; http://www.ufpb.br/inova/contents/documentos/tutorial-cpc-inpi.pdf(Accessed October 20, 2019)..
[34]
Carvalho BCCB, Santos MRMC. The international classification of patents: Description and importance. Rev GEINTEC 2019; 9(1): 4798-808.
[35]
Preveraud D, Rosilio V. Nanocapsules comprising a liposoluble active ingrediente, production and uses. M.X. Patent 2018011620, March 14,. 2019.
[36]
Yonghui W, Deguo W, Weiyun G, Guanghui L. Stable O/Wtype pickering emulsion by using hydroxyapatite nano particles and preparation method thereof. C.N. Patent 107595647, January 19,. 2018.
[37]
Assunção LS. Desenvolvimento e caracterização de nanopartículas poliméricas ricas em β-caroteno obtidas pela técnica de deslocamento de solvente Master Thesis, Federal University of Bahia: Salvador, February 2016.
[38]
Khatak S, Dureja H. Recent techniques and patents on solid lipid nanoparticles as novel carrier for drug delivery. Recent Pat Nanotechnol 2015; 9(3): 150-77.
[http://dx.doi.org/10.2174/1872210510999151126105754 ] [PMID: 27009132]
[http://dx.doi.org/10.2174/1872210510999151126105754 ] [PMID: 27009132]
[39]
McClements DJ, Xiao H. Is nano safe in foods? Establishing the factors impacting the gastrointestinal fate and toxicity of organic and inorganic food-grade nanoparticles. NPJ Sci Food 2017; 1(6): 6.
[http://dx.doi.org/10.1038/s41538-017-0005-1] [PMID: 31304248]
[http://dx.doi.org/10.1038/s41538-017-0005-1] [PMID: 31304248]
[40]
Rodriguez J, Martin MJ, Ruiz MA, Clares B. Current encapsulation strategies for bioactive oils: From alimentary to pharmaceutical perspectives. Food Res Int 2016; 83: 41-59.
[http://dx.doi.org/10.1016/j.foodres.2016.01.032]
[http://dx.doi.org/10.1016/j.foodres.2016.01.032]
[41]
Choi M, Ruktanonchai U, Min S, Chun J, Soottitantawat A. Physical characteristics of fish oil encapsulated by β-cyclodextrin using an aggregation method or polycaprolactone using an emulsion–diffusion method. Food Chem 2010; 119: 1694-703.
[http://dx.doi.org/10.1016/j.foodchem.2009.09.052]
[http://dx.doi.org/10.1016/j.foodchem.2009.09.052]
[42]
Esmaeili A, Saremnia B, Koohian A, Rezazadeh S. Mechanism of nanocapsules of Matricaria recutita L. extract formation by the emulsion–diffusion process. Superlattices Microstruct 2011; 50: 340-9.
[http://dx.doi.org/10.1016/j.spmi.2011.07.012]
[http://dx.doi.org/10.1016/j.spmi.2011.07.012]
[43]
Jamil B, Abbasi R, Abbasi S, et al. Encapsulation of cardamom essential oil in chitosan nano-composites: In-vitro efficacy on antibiotic-resistant bacterial pathogens and cytotoxicity studies. Front Microbiol 2016; 7: 1580.
[http://dx.doi.org/10.3389/fmicb.2016.01580] [PMID: 27757108]
[http://dx.doi.org/10.3389/fmicb.2016.01580] [PMID: 27757108]
[44]
Raveshi M, Keshavarz A, Mojarrad M, Amiri S. Experimental investigation of pool boiling heat transfer enhancement of alumina–water–ethylene glycol nanofluids. Exp Therm Fluid Sci 2013; 44: 805-14.
[http://dx.doi.org/10.1016/j.expthermflusci.2012.09.025]
[http://dx.doi.org/10.1016/j.expthermflusci.2012.09.025]
[45]
Sheikholeslami M, Rezaeianjouybari B, Darzi M, et al. Application of nano-refrigerant for boiling heat transfer enhancement employing an experimental study. Int J Heat Mass Transf 2019; 141: 974-80.
[http://dx.doi.org/10.1016/j.ijheatmasstransfer.2019.07.043]
[http://dx.doi.org/10.1016/j.ijheatmasstransfer.2019.07.043]
[46]
Sheikholeslami M. New computational approach for exergy and entropy analysis of nanofluid under the impact of Lorentz force through a porous media. Engineering 2019; 344: 319-33.
[47]
Tomioka J, Lourenço SR, Facó JFB. Nanotechnology patents: technological prospecting for decision making. Journal of INGEPRO 2006; 2(10): 1-12.
[48]
Ferreira CD, Nunes IL. Oil nanoencapsulation: Development, application, and incorporation into the food market. Nanoscale Res Lett 2019; 14(1): 9.
[http://dx.doi.org/10.1186/s11671-018-2829-2] [PMID: 30617711]
[http://dx.doi.org/10.1186/s11671-018-2829-2] [PMID: 30617711]
[49]
Depypere F, Dewettinck K, Ronsse F, Pieters J. Food powder microencapsulation: Principles, problems and opportunities. Appl Biotechnol Food Sci Policy 2003; 1(2): 75-94.
[50]
Fang Z, Bhandari B. Encapsulation of polyphenols – A review. Trends Food Sci Technol 2010; 21: 510-23.
[http://dx.doi.org/10.1016/j.tifs.2010.08.003]
[http://dx.doi.org/10.1016/j.tifs.2010.08.003]
[51]
Schaffazick SR, Guterres SS, Freitas LL, Pohlman AR. Characterization and physical-chemical stability of nanoparticulate polymeric systems for drug administration. Quim Nova 2013; 26(5): 726-37.
[http://dx.doi.org/10.1590/S0100-40422003000500017]
[http://dx.doi.org/10.1590/S0100-40422003000500017]
[52]
He X, Hwang HM. Nanotechnology in food science: Functionality, applicability, and safety assessment. Yao Wu Shi Pin Fen Xi 2016; 24(4): 671-81.
[http://dx.doi.org/10.1016/j.jfda.2016.06.001] [PMID: 28911604]
[http://dx.doi.org/10.1016/j.jfda.2016.06.001] [PMID: 28911604]
[53]
Cushen M, Kerry J, Morris M, Cruz M, Cummins E. Nanotechnologies in the food industry-Recent developments, risks and regulation. Trends Food Sci Technol 2012; 24: 30-46.
[http://dx.doi.org/10.1016/j.tifs.2011.10.006]
[http://dx.doi.org/10.1016/j.tifs.2011.10.006]
[54]
Linpin L, Lichang L, Yong Z, Xingyong W. Astaxanthin soft capsule formula and preparation method thereof. C.N. Patent 106, 923,334, July 07,. 2017.
[55]
Medina S, Camacho K, Santana I, Vázquez R, Cervantes P, Castello S. Stable nutraceutical composition and preparation process thereof. M.X. Patent 2, 015, 004,457, October 10, . 2016.
[56]
Almeida ML. Stability of water-in-oil emulsions in the presence of an external electric field Master Thesis, Federal University of Rio de Janeiro: Rio de Janeiro, March 2014.
[57]
Aghbashlo M, Mobli H, Madadlou A, Rafiee S. Fish oil microencapsulation as influenced by spray dryer operational variables. Int J Food Sci Technol 2013; 48(2): 1707-13.
[http://dx.doi.org/10.1111/ijfs.12141]
[http://dx.doi.org/10.1111/ijfs.12141]
[58]
Freixo L. C.A. Micro and nanoencapsulation as strategies for stabilization of bioactive entities: Proteins, enzymes and bacteriophages. Master Thesis, Fernando Pessoa University: Fernando Pessoa,. 2013.
[59]
Choi M, Ruktanonchai U, Scottitantawat A, Min S. Morphological characterization of encapsulated fish oil with β-cyclodextrin and polycaprolactone. Food Res Int 2009; 42: 989-97.
[http://dx.doi.org/10.1016/j.foodres.2009.04.019]
[http://dx.doi.org/10.1016/j.foodres.2009.04.019]
[60]
Pietro C, Calvo L. The encapsulation of low viscosity omega-3 rich fish oil in polycaprolactone by supercritical extraction of fluid emulsions. J Supercrit Fluids 2017; 128: 227-34.
[http://dx.doi.org/10.1016/j.supflu.2017.06.003]
[http://dx.doi.org/10.1016/j.supflu.2017.06.003]
[61]
Bernardi DS, Pereira TA, Maciel NR, et al. Formation and stability of oil-in-water nanoemulsions containing rice bran oil: In vitro and in vivo assessments. J Nanobiotechnology 2011; 9: 44.
[http://dx.doi.org/10.1186/1477-3155-9-44] [PMID: 21952107]
[http://dx.doi.org/10.1186/1477-3155-9-44] [PMID: 21952107]
[62]
Ricaurte L, Perea-Flores MJ, Martinez A, Quintanilla-Carvajal MX. Production of high-oleic palm oil nanoemulsions by high-shear homogenization (microfluidization). Innov Food Sci Emerg 2016; 35: 75-85.
[http://dx.doi.org/10.1016/j.ifset.2016.04.004]
[http://dx.doi.org/10.1016/j.ifset.2016.04.004]
[63]
Jarasi SM, Assadpoor E, Bhandari B, He Y. Nano-particle encapsulation of fish oil by spray drying. Food Res Int 2008; 41: 172-83.
[http://dx.doi.org/10.1016/j.foodres.2007.11.002]
[http://dx.doi.org/10.1016/j.foodres.2007.11.002]
[64]
Xue J, Michael Davidson P, Zhong Q. Antimicrobial activity of thyme oil co-nanoemulsified with sodium caseinate and lecithin. Int J Food Microbiol 2015; 210: 1-8.
[http://dx.doi.org/10.1016/j.ijfoodmicro.2015.06.003 ] [PMID: 26082324]
[http://dx.doi.org/10.1016/j.ijfoodmicro.2015.06.003 ] [PMID: 26082324]
[65]
Wei L, Liqiang Z, Dongwen F. Preparation device and preparation method of DHA alga oil nano liposome. C.N. Patent 109, 589,321, April 09,. 2019.
[66]
Seiji K, Koji N. Composite type solubilized nanoliposome and method for producing the same. J.P. Patent 2, 016, 163,851, Setember 08, . 2016.
[67]
Rosani L. Development and study of the stability of oil-in-water nanoemulsions with vegetable oils . Master Thesis, Federal University of São Carlos: São Carlos,. 2011.
[68]
Dan L, Yiqin M, Weiyu W, Lijun D. Dihydromyricetin watersoluble nanosuspension agent, and preparing method and application thereof. C.N. Patent 108, 670,953, October 19, . 2018.
[69]
Junbo E, Hao S, Weinong Z, Lijuan H. Diglyceride-based nanostructure lipid carrier dispersing solution as well as preparation method and application thereof. C.N. Patent 108969477, December 11,. 2018.
[70]
Jiang Y, Quan X, Jiang G, Li X. Current prospective on environmental nanotechnology research in China. Environ Sci Technol 2019; 53(8): 4001-2.
[http://dx.doi.org/10.1021/acs.est.9b01489] [PMID: 30916542]
[http://dx.doi.org/10.1021/acs.est.9b01489] [PMID: 30916542]
[71]
Sarmento C. Com forte crescimento econômico, Ásia investe em ensino superior,; 2014.https://oglobo.globo.com/economia/com-forte-crescimento-economico-asia-investe-em-ensino-superior-11212083[Accessed October 29, 2019]..
[72]
Huang C, Wu Y. State-led technological development: A case of China’s nanotechnology development. World Dev 2012; 40(5): 970-82.
[http://dx.doi.org/10.1016/j.worlddev.2011.11.013]
[http://dx.doi.org/10.1016/j.worlddev.2011.11.013]
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