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Review Article

肽构象分析中的核磁共振波谱：概述

卷 28, 期 14, 2021

发表于: 02 July, 2020

页: [2729 - 2782] 页: 54

弟呕挨: 10.2174/0929867327666200702131032

价格: $65

摘要

背景：核磁共振光谱是从动态角度研究肽和蛋白质的结构和相互作用特性的最强大的工具之一。了解肽的生物活性构象对于设计更有效的类似物配体和靶向治疗相关系统的蛋白质-蛋白质相互作用抑制剂至关重要。 目的：这篇综述提供了一个通过 NMR 研究肽构象特性的工具包。 方法：本文引用的与肽和蛋白质的 NMR 研究相关的文章主要通过 PubMed 和网络进行搜索。还查阅了该领域著名科学家撰写的有关核磁共振波谱的较新和旧书籍。 结果：审查主要集中在核磁共振工具上，以获得未标记的小肽的 3D 结构。它更加面向应用，因为它超出了提供深刻理论背景的目标。但是，简要描述了二维同核和异核实验的基本原理。还讨论了获得同位素标记肽的方案和研究它们所需的主要三重共振实验。 结论： NMR 是研究小柔性肽的构象偏好的领先技术，其结构通常只能由一组构象来描述。虽然肽的核磁共振研究可以通过几十年前建立的规范协议轻松快速地进行，但最近我们已经协助核磁共振光谱的巨大改进，以研究大型系统并克服其分子量限制。

关键词: 核磁共振、结构生物学、肽、蛋白质、构象集合、距离和角度限制、生物活性构象。

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