Antibiotic Adjuvants to Rescue Pseudomonas aeruginosa from Tetracycline Antibiotics Resistance

Title:Antibiotic Adjuvants to Rescue Pseudomonas aeruginosa from Tetracycline Antibiotics Resistance

Volume: 19 Issue: 1

Author(s): Azza Troudi, Hana Douafer, Jean-Michel Bolla, Naouel Klibi and Jean M. Brunel*

Affiliation:

• Aix Marseille Univ, INSERM, SSA, MCT, 13385 Marseille,France

Keywords: Polyaminoisoprenyl derivatives, antibiotic adjuvants, polyamines, Pseudomonas aeruginosa, tetracycline antibiotic.

Abstract:

Introduction: An attractive antibiotic-adjuvant strategy consisting of the design and synthesis of polyaminoisoprenyl molecules able to restore the antibiotic activity of tetracycline antibiotics against resistant Pseudomonas aeruginosa bacterial strains has been developed.

Methods: These chemo-sensitizers are readily prepared from geraniol and farnesol in an efficient two steps synthesis with good to moderate yields varying from 38 to 64% and leading to a significant decrease in antibiotic resistance.

Results: Thus, the influence of the nature of the tetracycline antibiotic used as well as the structure of the polyaminoisoprenyl derivatives involved in the outcome of the antibiotic-adjuvant combination against P. aeruginosa resistance to tetracyclines were investigated.

Conclusion: Additionally, our data suggested that their mechanism of action is closely associated with the increase of the outer-membrane permeability.

Cite this article as:

Troudi Azza , Douafer Hana , Bolla Jean-Michel , Klibi Naouel and Brunel M. Jean *, Antibiotic Adjuvants to Rescue Pseudomonas aeruginosa from Tetracycline Antibiotics Resistance, Anti-Infective Agents 2021; 19 (1) . https://dx.doi.org/10.2174/2211352518999200629164624