Abstract
SERMs represent a structurally diverse group of compounds which interact with the estrogen receptor but which elicit agonist or antagonist activity depending on the organ system and physiological context. Evaluation of the actions of these compounds has led researchers to a fuller understanding not only of the antiestrogens but also of steroid signaling in general. Based on their evolving clinical profiles, SERMs have the potential to address long-term health maintenance needs of women in their non-reproductive years.
Keywords: selective estrogen receptor modulators SERMs, antiestrogens, tamoxifen, raloxifene
Current Medicinal Chemistry
Title: Selective Estrogen Receptor Modulators (SERMs): Effects on Multiple Organ Systems
Volume: 7 Issue: 5
Author(s): D. Agnusdei and N. Iori
Affiliation:
Keywords: selective estrogen receptor modulators SERMs, antiestrogens, tamoxifen, raloxifene
Abstract: SERMs represent a structurally diverse group of compounds which interact with the estrogen receptor but which elicit agonist or antagonist activity depending on the organ system and physiological context. Evaluation of the actions of these compounds has led researchers to a fuller understanding not only of the antiestrogens but also of steroid signaling in general. Based on their evolving clinical profiles, SERMs have the potential to address long-term health maintenance needs of women in their non-reproductive years.
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Cite this article as:
Agnusdei D. and Iori N., Selective Estrogen Receptor Modulators (SERMs): Effects on Multiple Organ Systems, Current Medicinal Chemistry 2000; 7 (5) . https://dx.doi.org/10.2174/0929867003375056
DOI https://dx.doi.org/10.2174/0929867003375056 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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