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Review Article

利用药物开发新疾病的目的：对策略和案例研究的认识

卷 21, 期 2, 2021

发表于: 19 June, 2020

页: [111 - 132] 页: 22

弟呕挨: 10.2174/1566524020666200619125404

价格: $65

摘要

背景：传统的药物发现是耗时，昂贵且风险很大的过程。由于投资大，人员流失过多和产量下降，重新利用药物已成为鉴定和开发新疗法的新兴方法。在过去的几年中，该方法获得了发展势头，并产生了许多出色的发现。为了节省时间和成本，工业界正在恢复这些失败和搁置的药品。近年来，该过程约占新获得美国食品药品监督管理局（FDA）批准的药品和疫苗的30％。 方法：使用适当的关键字进行系统的文献检索，以识别讨论正在采用的不同策略和已/正被改种的各种药物的文章。 结果：这篇综述旨在描述用于再利用的各种策略（盲法搜索，计算方法和实验方法）的综合数据，以及成功的案例研究（孤儿疾病，被忽视的热带病，神经退行性疾病的治疗以及用于治疗糖尿病的药物）儿科人群）。它还详细列出了已重新定位的100多种药物，采用的方法及其当前的临床状况。我们还尝试合并用于计算用途的不同数据库。 结论：所提供的数据证明，重新利用药物是多产的方法，可以规避传统药物发现方法可能带来的问题。这是一种很有前途的方法，当与复杂的计算工具结合使用时，它也具有很高的精度。该综述将有助于研究确定药物开发方法的优先次序，这是发展药物发现研究所需要的。

关键词: 重用方法，罕见疾病，癌症，神经退行性疾病，被忽视的热带病，案例研究，计算工具和数据库。

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