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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

可变剪接在肿瘤免疫细胞相互作用中的用途

卷 20, 期 10, 2020

页: [729 - 740] 页: 12

弟呕挨: 10.2174/1568009620666200619123725

open access plus

摘要

可变剪接(AS)在肿瘤的特征中发挥重要作用，可为免疫治疗提供新抗原。本文综述了AS产生的免疫系统相关肿瘤特异性抗原(TSAs)的研究进展。我们将进一步讨论as介导的固有和适应性免疫应答的调节机制，以及在不同类型癌症中的抗肿瘤和原瘤作用。例如，ULBP1_RI ，MLL5_21spe，NKp44-1_5， MHC-I_7, CD200S_1, 2, PVRα/β、γ、δ和IL-33变体1/2/3在血液癌症中发挥了监管机构实体肿瘤和IPAK4-L, FOXP1ΔN100展示功能。

关键词: 可变剪接，肿瘤细胞，免疫系统，免疫治疗，新抗原，肿瘤特异性抗原(TSAs)

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