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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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General Research Article

Preoperative Circulating MiR-210, a Risk Factor for Postoperative Delirium Among Elderly Patients with Gastric Cancer Undergoing Curative Resection

Author(s): Yun Chen, Jinwei Zheng and Junping Chen*

Volume 26, Issue 40, 2020

Page: [5213 - 5219] Pages: 7

DOI: 10.2174/1381612826666200617163857

Price: $65

Abstract

Background: Postoperative delirium (POD) is a very common complication in elderly patients with gastric cancer (GC) and associated with poor prognosis. MicroRNAs (miRNAs) serve as key post-transcriptional regulators of gene expression via targeting mRNAs and play important roles in the nervous system. This study aimed to investigate the potential predictive role of miRNAs for POD.

Methods: Elderly GC patients who were scheduled to undergo elective curative resection were consequently enrolled in this study. POD was assessed at 1 day before surgery and 1-7 days after surgery following the guidance of the 5th edition of Diagnostic and Statistical Manual of Mental Disorders (DSM V, 2013). The demographics, clinicopathologic characteristics and preoperative circulating miRNAs by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) were compared between patients with or without POD. Risk factors for POD were assessed via univariate and multivariate logistic regression analyses.

Results: A total of 370 participants were enrolled, of which 63 had suffered from POD within postoperative 7 days with an incidence of 17.0%. Preoperative miR-210 was a predictor for POD with an area under the curve (AUC) of 0.921, a cut-off value of 1.67, a sensitivity of 95.11%, and a specificity of 92.06%, (P<0.001). In the multivariate logistic regression model, the relative expression of serum miR-210 was an independent risk factor for POD (OR: 3.37, 95%CI: 1.98–5.87, P=0.003).

Conclusions: In conclusion, the present study highlighted that preoperative miR-210 could serve as a potential predictor for POD in elderly GC patients undergoing curative resection.

Keywords: Gastric cancer, postoperative delirium, biomarker, microRNAs, curative, univariate.

« Previous
[1]
Ferro A, Peleteiro B, Malvezzi M, et al. Worldwide trends in gastric cancer mortality (1980-2011), with predictions to 2015, and incidence by subtype. Eur J Cancer 2014; 50(7): 1330-44.
[http://dx.doi.org/10.1016/j.ejca.2014.01.029] [PMID: 24650579]
[2]
Seo SH, Hur H, An CW, et al. Operative risk factors in gastric cancer surgery for elderly patients. J Gastric Cancer 2011; 11(2): 116-21.
[http://dx.doi.org/10.5230/jgc.2011.11.2.116] [PMID: 22076212]
[3]
Hwang H, Lee KM, Son KL, et al. Incidence and risk factors of subsyndromal delirium after curative resection of gastric cancer. BMC Cancer 2018; 18(1): 765.
[http://dx.doi.org/10.1186/s12885-018-4681-2] [PMID: 30053850]
[4]
Whitlock EL, Vannucci A, Avidan MS. Postoperative delirium. Minerva Anestesiol 2011; 77(4): 448-56.
[PMID: 21483389]
[5]
Maldonado JR. Delirium in the acute care setting: characteristics, diagnosis and treatment. Crit Care Clin 2008; 24(4): 657-722.
[http://dx.doi.org/10.1016/j.ccc.2008.05.008] [PMID: 18929939]
[6]
Shin YH, Kim DK, Jeong HJ. Impact of surgical approach on postoperative delirium in elderly patients undergoing gastrectomy: laparoscopic versus open approaches. Korean J Anesthesiol 2015; 68(4): 379-85.
[http://dx.doi.org/10.4097/kjae.2015.68.4.379] [PMID: 26257851]
[7]
Naeije G, Pepersack T. Delirium in elderly people. Lancet 2014; 383(9934): 2044-5.
[http://dx.doi.org/10.1016/S0140-6736(14)60993-4] [PMID: 24931688]
[8]
Marcantonio ER, Kiely DK, Simon SE, et al. Outcomes of older people admitted to postacute facilities with delirium. J Am Geriatr Soc 2005; 53(6): 963-9.
[http://dx.doi.org/10.1111/j.1532-5415.2005.53305.x] [PMID: 15935018]
[9]
Zubakov D, Boersma AW, Choi Y, van Kuijk PF, Wiemer EA, Kayser M. MicroRNA markers for forensic body fluid identification obtained from microarray screening and quantitative RT-PCR confirmation. Int J Legal Med 2010; 124(3): 217-26.
[http://dx.doi.org/10.1007/s00414-009-0402-3] [PMID: 20145944]
[10]
Bhat SA, Majid S, Rehman MU. Scenario and future prospects of microRNAs in gastric cancer: A review. Iran J Basic Med Sci 2019; 22(4): 345-52.
[PMID: 31168337]
[11]
Grasso M, Piscopo P, Confaloni A, Denti MA. Circulating miRNAs as biomarkers for neurodegenerative disorders. Molecules 2014; 19(5): 6891-910.
[http://dx.doi.org/10.3390/molecules19056891] [PMID: 24858274]
[12]
Dong R, Sun L, Lu Y, Yang X, Peng M, Zhang Z. NeurimmiRs and postoperative delirium in elderly patients undergoing total hip/knee replacement: A pilot study. Front Aging Neurosci 2017; 9: 200.
[http://dx.doi.org/10.3389/fnagi.2017.00200] [PMID: 28690539]
[13]
Kondo M, Yamada H, Munetsuna E, et al. Associations of serum microRNA-20a, -27a, and -103a with cognitive function in a Japanese population: The Yakumo study. Arch Gerontol Geriatr 2019; 82: 155-60.
[http://dx.doi.org/10.1016/j.archger.2019.01.007] [PMID: 30802839]
[14]
Washington K. 7th edition of the AJCC cancer staging manual: stomach. Ann Surg Oncol. In: 2010; 17: pp. 3077-9.
[15]
Siedlecki-Wullich D, Català-Solsona J, Fábregas C, et al. Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease. Alzheimers Res Ther 2019; 11(1): 46.
[http://dx.doi.org/10.1186/s13195-019-0501-4] [PMID: 31092279]
[16]
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Method Methods 2001; 25(4): 402-8.
[http://dx.doi.org/10.1006/meth.2001.1262] [PMID: 11846609]
[17]
Tei M, Ikeda M, Haraguchi N, et al. Risk factors for postoperative delirium in elderly patients with colorectal cancer. Surg Endosc 2010; 24(9): 2135-9.
[http://dx.doi.org/10.1007/s00464-010-0911-7] [PMID: 20177939]
[18]
Kratz T, Heinrich M, Schlauß E, Diefenbacher A. Preventing postoperative delirium. Dtsch Arztebl Int 2015; 112(17): 289-96.
[PMID: 26008890]
[19]
Cheng Q, Li L, Yang M, et al. Moderate hypercapnia may not contribute to postoperative delirium in patients undergoing bronchoscopic intervention. Medicine (Baltimore) 2019; 98(22):e15906.
[http://dx.doi.org/10.1097/MD.0000000000015906] [PMID: 31145352]
[20]
Honda S, Furukawa K, Nishiwaki N, et al. Risk factors for postoperative delirium after gastrectomy in gastric cancer patients. World J Surg 2018; 42(11): 3669-75.
[http://dx.doi.org/10.1007/s00268-018-4682-y] [PMID: 29850948]
[21]
Leung JM, Sands LP, Vaurio LE, Wang Y. Nitrous oxide does not change the incidence of postoperative delirium or cognitive decline in elderly surgical patients. Br J Anaesth 2006; 96(6): 754-60.
[http://dx.doi.org/10.1093/bja/ael106] [PMID: 16670110]
[22]
Benoit AG, Campbell BI, Tanner JR, et al. Risk factors and prevalence of perioperative cognitive dysfunction in abdominal aneurysm patients. J Vasc Surg 2005; 42(5): 884-90.
[http://dx.doi.org/10.1016/j.jvs.2005.07.032] [PMID: 16275442]
[23]
Cereghetti C, Siegemund M, Schaedelin S, et al. Independent predictors of the duration and overall burden of postoperative delirium after cardiac surgery in adults: An observational cohort study. J Cardiothorac Vasc Anesth 2017; 31(6): 1966-73.
[http://dx.doi.org/10.1053/j.jvca.2017.03.042] [PMID: 28711314]
[24]
Pol RA, van Leeuwen BL, Izaks GJ, et al. C-reactive protein predicts postoperative delirium following vascular surgery. Ann Vasc Surg 2014; 28(8): 1923-30.
[http://dx.doi.org/10.1016/j.avsg.2014.07.004] [PMID: 25017770]
[25]
Plas M, Hemmer PHJ, Been LB, van Ginkel RJ, de Bock GH, van Leeuwen BL. Incidence and predictors of postoperative delirium after cytoreduction surgery-hyperthermic intraperitoneal chemotherapy. J Surg Oncol 2018; 117(2): 260-8.
[http://dx.doi.org/10.1002/jso.24811] [PMID: 28940461]
[26]
Slor CJ, Witlox J, Adamis D, et al. The trajectory of C-reactive protein serum levels in older hip fracture patients with postoperative delirium. Int J Geriatr Psychiatry 2019; 34(10): 1438-46.
[http://dx.doi.org/10.1002/gps.5139] [PMID: 31058343]
[27]
Xiang D, Xing H, Tai H, Xie G. Preoperative C-Reactive protein as a risk factor for postoperative delirium in elderly patients undergoing laparoscopic surgery for colon carcinoma. BioMed Res Int 2017; 20175635640
[http://dx.doi.org/10.1155/2017/5635640] [PMID: 29181397]
[28]
Cheng LC, Pastrana E, Tavazoie M, Doetsch F. miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nat Neurosci 2009; 12(4): 399-408.
[http://dx.doi.org/10.1038/nn.2294] [PMID: 19287386]
[29]
Sun Y, Li Q, Gui H, et al. MicroRNA-124 mediates the cholinergic anti-inflammatory action through inhibiting the production of pro-inflammatory cytokines. Cell Res 2013; 23(11): 1270-83.
[http://dx.doi.org/10.1038/cr.2013.116] [PMID: 23979021]
[30]
Liu XS, Chopp M, Zhang RL, et al. MicroRNA profiling in subventricular zone after stroke: MiR-124a regulates proliferation of neural progenitor cells through Notch signaling pathway. PLoS One 2011; 6(8)e23461
[http://dx.doi.org/10.1371/journal.pone.0023461] [PMID: 21887253]
[31]
White K, Lu Y, Annis S, et al. Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Mol Med 2015; 7(6): 695-713.
[http://dx.doi.org/10.15252/emmm.201404511] [PMID: 25825391]
[32]
Zaccagnini G, Maimone B, Di Stefano V, et al. Hypoxia-induced miR-210 modulates tissue response to acute peripheral ischemia. Antioxid Redox Signal 2014; 21(8): 1177-88.
[http://dx.doi.org/10.1089/ars.2013.5206] [PMID: 23931770]
[33]
Kim HW, Haider HK, Jiang S, Ashraf M. Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2. J Biol Chem 2009; 284(48): 33161-8.
[http://dx.doi.org/10.1074/jbc.M109.020925] [PMID: 19721136]
[34]
Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab 2009; 10(4): 273-84.
[http://dx.doi.org/10.1016/j.cmet.2009.08.015] [PMID: 19808020]
[35]
Zaccagnini G, Maimone B, Fuschi P, et al. Overexpression of miR-210 and its significance in ischemic tissue damage. Sci Rep 2017; 7(1): 9563.
[http://dx.doi.org/10.1038/s41598-017-09763-4] [PMID: 28842599]
[36]
Hu S, Huang M, Li Z, et al. MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation 2010; 122(11)(Suppl.): S124-31.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.109.928424] [PMID: 20837903]
[37]
Bostjancic E, Zidar N, Glavac D. MicroRNA microarray expression profiling in human myocardial infarction. Dis Markers 2009; 27(6): 255-68.
[http://dx.doi.org/10.1155/2009/641082] [PMID: 20075508]
[38]
Li T, Cao H, Zhuang J, et al. Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans. Clin Chim Acta 2011; 412(1-2): 66-70.
[http://dx.doi.org/10.1016/j.cca.2010.09.029] [PMID: 20888330]
[39]
Chen Z, Li Y, Zhang H, Huang P, Luthra R. Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression. Oncogene 2010; 29(30): 4362-8.
[http://dx.doi.org/10.1038/onc.2010.193] [PMID: 20498629]
[40]
Chan YC, Banerjee J, Choi SY, Sen CK. miR-210: the master hypoxamir. Microcirculation 2012; 19(3): 215-23.
[http://dx.doi.org/10.1111/j.1549-8719.2011.00154.x] [PMID: 22171547]
[41]
Wang Y, Shen X. Postoperative delirium in the elderly: the potential neuropathogenesis. Aging Clin Exp Res 2018; 30(11): 1287-95.
[http://dx.doi.org/10.1007/s40520-018-1008-8] [PMID: 30051417]
[42]
Maldonado JR. Neuropathogenesis of delirium: review of current etiologic theories and common pathways. Am J Geriatr Psychiatry 2013; 21(12): 1190-222.
[http://dx.doi.org/10.1016/j.jagp.2013.09.005] [PMID: 24206937]

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